Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2018, Vol. 32 ›› Issue (6): 92-97.doi: 10.6040/j.issn.1673-3770.0.2018.272

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Clinical study of compaq combined with laser in the treatment of retinopathy of prematurity

GUO Bao, ZHANG Deyong   

  1. Department of Ophthalmology, Xuzhou Childrens Hospital, Xuzhou 221006, Jiangsu, China
  • Published:2018-11-29

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Abstract: Objective To observe the clinical effect of treatment with Compaq, laser, and a combination for the treatment of retinopathy of prematurity(ROP). Methods Sixty-three children(126 eyes)with ROP treated in our hospital from February 2016 to December 2017 were randomly divided into three groups of 21 patients(42 eyes)using the envelope method. Laser photocoagulation treatment group was treated with laser photocoagulation alone, compaq treatment group was treated with compaitcept glass cavity injection alone, and combined treatment group was treated with compaitcept glass body cavity injection and laser irradiation combined with laser photocoagulation. The clinical effects observed in the three groups were compared, and the indices related to the retinal electroretinogram and changes in the equivalent spherical mirror and astigmatism were analyzed. Complications and follow-up results were analyzed during and after treatment. Results The rate of controlled disease in laser photocoagulation treatment group, compaq treatment group and combined treatment group was 71.43%, 66.67% and 95.24%(H=5.694, P=0.058). Regarding the amplitude of the flash electroretinogram(F-ERG)reaction, the amplitude of the b-wave, the cone-rod mixed maximum response a- and b-waves, there was significant difference between the above three groups(all P<0.05). Regarding the F-ERG response latency, peak mixed rod-cone response a- and b-wave, there was significant difference between the above three groups(all P<0.05). Regarding myopia, high myopia, astigmatism, and high astigmatism, there was significant difference between the above three groups(all P<0.05). The incidence of complications was 23.80%, 19.04% and 14.28%(χ2=0.618, P=0.432)in laser photocoagulation treatment group, compaq treatment group and combined treatment group. During the follow-up period, the recurrence rate of ROP in laser photocoagulation treatment group, compaq treatment group and combined treatment group was 33.33%、28.57% and 4.76%. The recurrence rate of ROP in laser photocoagulation treatment group and compaq treatment group significantly higher than that in combined treatment group(all P<0.05). Conclusion Treatment with Compaq combined with laser is effective and safe for the treatment of ROP.

Key words: Compaq, laser, Rapid advance, Premature, Retinopathy of prematurity

CLC Number: 

  • R779.7
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