Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (2): 125-132.doi: 10.6040/j.issn.1673-3770.0.2024.125

• Review • Previous Articles    

Topical pharmacologic treatment of dry eye disease associated with meibomian gland dysfunction

NING Yuyun1, LI Tong2, ZHANG Xinxin3   

  1. 1. Graduate School, Shanxi Medical University, Taiyuan 030000, Shanxi, China2. Department of Ophthalmology, The Second Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi, China3. Comprehensive Examination Department, Shanxi Provincial Eye Hospital, Taiyuan 030000, Shanxi, China
  • Published:2026-03-26

Abstract: Dry eye is a common multifactorial ocular surface disease that affects millions of people worldwide, and its incidence is increasing with the rapid development of society. Alterations in tear film structure, properties, and ocular surface homeostasis triggered by meibomian gland dysfunction are one of the major factors contributing to dry eye. Treatment modalities include pharmacologic, physical, and surgical interventions. Topical pharmacotherapy options include antimicrobials, lipid-containing artificial tears, anti-inflammatory agents, tear secretion promoters, hormonal ophthalmic preparations, and novel drugs such as perfluorohexyloctane. This article reviews the topical pharmacologic treatment of dry eye associated with meibomian gland dysfunction.

Key words: Meibomian gland dysfunction, Dry eye disease, Tear film lipid layer, Perfluorohexane

CLC Number: 

  • R777.34
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