Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (3): 75-80.doi: 10.6040/j.issn.1673-3770.1.2020.022

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Clinical effect of Hashimoto thyroiditis on the ratio of BRAFV600E alleles in papillary thyroid carcinoma

NI Yeqin1, WU Fan1, XUN Yanping2, ZHAO Pan3, ZHANG Shirong2, ZHOU Tianhan1, SUN Sihan4, LU Kaining4, LUO Dingcun5   

  1. 1. The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang, China;
    2. Centre of Translational Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China;
    3. Department of Pathology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang China;
    4. Nanjing Medical University Nanjing 210000, Jiangsu, China;
    5. Department of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China;
  • Published:2020-06-29

Abstract: Objective To evaluate the clinical effect of Hashimoto thyroiditis(HT)on the ratio of BRAFV600E alleles in papillary thyroid carcinoma(PTC). Methods Two hundred and forty-two patients who underwent surgery at our hospital between December 2017 and December 2019 were enrolled in this study. The ratio of BRAFV600E alleles was measured using droplet digital PCR and formalin-fixed paraffin-embedded tissues, and its correlation with HT was analyzed. Using propensity score matching and based on the 63 patients with HT(1∶1), 179 PTC patients without HT during the same period were retrospectively enrolled as controls. Results There was a significant difference between the ratio of BRAFV600E alleles(P<0.001)of the two groups(PTC patients with HT versus those without HT); the rates of positive-BRAFV600E were not significantly different(87.3% vs 92.7%, P>0.05). After propensity score matching, the significant difference between the two groups at baseline was no longer observed. The ratio of BRAFV600E alleles was still significantly lower in patients with HT(median 3.20%)than in those without HT(median 9.00%, P=0.001). Conclusion HT can significantly reduce the ratio of BRAFV600E alleles in PTC, and this has an important effect on PTC progression and prognosis.

Key words: Thyroid neoplasms, Propensity score matching, Hashimoto thyroiditis, Ratio of BRAFV600E alleles

CLC Number: 

  • R604
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