Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (3): 120-124.doi: 10.6040/j.issn.1673-3770.1.2020.034

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Preliminary analysis of the anterior superior mediastinal lymph node metastasis in thyroid papillary carcinoma

NING Yudong, CAI Yongcong, SUN Ronghao, JIANG Jian, ZHOU Yuqiu, SHUI Chunyan, WANG Xu, ZHENG Wanghu,   

  1. HE Tianqi, LI ChaoDepartment of Head and Neck surgery, Cancer Hospital Affiliate to School of Medicine, University of Electronic and Technology of China / Sichuan Institute of Cancer Research / Sichuan Cancer Prevention and Control Center / Sichuan Cancer Hospital, Chengdu 610041, Sichuan, China
  • Published:2020-06-29

Abstract: Objective To investigate the relationship between clinicopathological features such as the tumor location, maximum diameter, extranodal thyroid invasion, and anterior superior mediastinal lymph node metastasis of thyroid carcinoma. Methods We analyzed the clinical and pathological data of 60 patients with thyroid papillary carcinoma who were admitted to the Head and Neck Surgery Department at Sichuan Cancer Hospital for primary surgery between September 2018 and February 2019. The correlation between the clinical and pathological features and the positive rate of the anterior and upper mediastinal lymph nodes was analyzed using the chi-square test. Results Among the features of tumor location, maximum diameter, number, extranodal invasion, number of involved gland lobes and lymph node metastasis in region Ⅵ, as well as the age of patients and other relevant factors, only the lymph nodes in region Ⅵ affected the status of anterior superior mediastinal lymph nodes. Ten of the 60 patients(16.67%)had anterior superior mediastinal lymph node metastasis. The rates of anterior superior mediastinal lymph node metastasis were compared among the related factors: age > or equal to 55 years vs. younger than 55 years(20% vs. 16.36%; P<0.05); mass located in the lower pole vs. the upper pole vs. the middle pole(P>0.05); maximum diameter greater than or equal to 1.5 cm vs. less than 1.5 cm(18.18% vs. 15.79; p >0.05), single focus vs. multiple focus(21.88% vs. 10.71%; P>0.05), single vs. multiple leaves(17.5% vs. 15%; P>0.05); males vs. females(20% vs. 15.55%; P>0.05); positive vs. negative lymph nodes in area Ⅵ(24.43% vs. 3.57%; P<0.05). Conclusion The rate of anterior and upper mediastinal lymph node metastasis in thyroid papillary carcinoma is relatively low. In this study, it was found that the status of lymph nodes in Ⅵ region may be related to anterior superior mediastinal lymph node metastasis, and prospective studies with large samples are still needed in the future.

Key words: Papillary carcinoma of thyroid, Cervical lymph node metastasis, Anterior superior mediastinal lymph nodes, Lymph nodes in central region, Tumor

CLC Number: 

  • R736
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