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Resistance of methicillin-resistant staphylococcus to antibiotics for chronic nasosinusitis

CHEN Jun1, FU Ai-qing1, ZHU Qiu-ping1, LOU Zheng-cai2   

  1. 1. Department of Clinical Laboratory; 2. Department of Otolaryngology, Yiwu Central Hospital,Yiwu 322000, Zhejiang, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: CHEN Jun

Abstract: To investigate the infective rate of methicillin-resistant staphylococcus(MRS) and its resistance characteristics so as to provide a basis for the clinically rational use of anti-microbial agents and an effective control of MRS infections. Methods: Strains of staphylococcus from clinical samples were determined by a disc agar diffusion method and MRS agar plate screening. At the same time their resistance to 20 different anti-microbial agents and the presence of β-lactamase in the strains were determined. Results: Twenty-seven strains of MRSA and thirty-three strains of MRSCoN were identified. The proportion of MRSA and MRSCoN was 37.6% and 38.3%, respectively. The incidence of MRSA and MRSCoN producing βlactamase was 77.8% and 72.7% ,respectively. The resistance rate showed a significant difference between the MRS and the MSS(P<0.05).The multi-resistance ranged from 6 to 17 and 5 to 15 antibiotics in MRSA and MRSCoN. Conclusions: Vancomycin, Rifampin and Amikacin have effective antibacterial activity against MRS. Vancomycin is the first choice for MRS infections. Wide attention should be paid to the multi-resistance of MRS, and the use of antibiotics should be better managed and the resistance of MRS to antibiotics should be further monitored.

Key words: Chronic nasosinusitis, Methicillin resistance,  Staphylococcus, Antibiotics

CLC Number: 

  • R765.23
[1] FU Yafeng, FENG Xiaolian, LIN Meifang, LONG Chaoqing. Evaluation the significance of antibiotics in septoplasty peri-operation duration [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 29-30.
[2] WANG Lin,SUN Yan,CHEN Zhi-jun,LI Wei,SUN Wen-hai . Clinical features and management of Methicillin-resistant Staphylococcus Aureus (MRSA) infection after laryngectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 127-129 .
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