非综合征型耳聋线粒体基因A1555G突变分析

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Molecular genetic analysis of the mtDNA A1555G mutation in patients with nonsyndromic hearing loss

LIU Tao¹, BAO Yin², YAN Jiangwei³, LI Lingxiang¹, LI Jianrui⁴

(1. Department of ENT, Hospital Attached to Inner Mongolia Medical College, Inner Mongolia Hohhot 010059, China;
2. Department of ENT, Central Hospital of Erdos, Inner Mongolia Erdos 017000, China；
3. Beijing Genomics Institute of Chinese Academy of Sciences, Beijing 100029, China;
4. Department of ENT, Hospital Attached to Inner Mongolia Medical College, but now in Beijing Chui Yang Liu Hospital,
Beijing 100022, China)

Received:1900-01-01 Revised:1900-01-01 Online:2009-02-16 Published:2009-02-16
Contact: LI Jianrui

Abstract

Abstract: To analyze the prevalence of an AtoG mutation at nucleotide 1555 of the mitochondrial genome in 102 patients with nonsyndromic hearing loss in Erdos, Inner Mongolia. MethodsData on the medical history of 102 deaf school students were collected by a questionnaire survey. An audiological examination was conducted with puretone audiometry (Madsen Orbiter 922) and acoustic immittance measurement(Madsen ZODIAC 901). The MtDNA 12SrRNA A1555G mutation was identified by restriction enzyme AIW26I digestion. ResultsAll 102 patients were proved to have sensorineural hearing impairment. 54 of them had used aminoglycoside antibiotics. 7 cases (6.9%) carried the mtDNA A1555G mutation. ConclusionThe mtDNA 12S rRNA A1555G mutation has a relatively high incidence in people with nonsyndromic sensorineural hearing loss. The MtDNA A1555G mutation is related to aminoglycoside antibioticsinduced deafness, which can cause genetic susceptibility to aminoglycoside antibiotics ototoxicity.

CLC Number:

R764.43

LIU Tao¹, BAO Yin², YAN Jiangwei³, LI Lingxiang¹, LI Jianrui⁴. Molecular genetic analysis of the mtDNA A1555G mutation in patients with nonsyndromic hearing loss[J].JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(1): 40-42 .