Abstract: To explore the relationship between changes of serum lipid metabolism, uric acid and sudden sensorineurol hearing loss(SSNHL). MethodsThe serum levels of triglyceride(TG), cholesterol(CHO), high density lipoproteincholesterol(HDLCH), low density lipoproteincholesterol(LDLCH), apolipoprotein AI(Apo AI), apolipoprotein B （Apo B）and uric acid（UA） in 100 patients with sudden sensorineurol hearing loss and 56 controls were determined. ResultsThe serum levels of high lipoproteincholesterol were significantly decreased (P<0.05) and uric acid significantly increased (P<0.05) in the sudden sensorineural hearing loss group in comparison with the control group. There were no significant differences of high　lipoproteincholesterol or uric acid in any agegroup, also there were no significant differences in levels of TG, CHO, LDLCH, AｐｏAI and AｐｏB between the sudden sensorineural hearing loss groups and the control groups（Ｐ>0.05）. ConclusionMetabolic disturbance of serum lipids and uric acid in patients with sudden sensorineurol hearing loss may be related to the etiology of sudden sensorineural hearing loss.