Abstract:

Objective  To evaluate the clinical effect of Avastin on vitrectomy for proliferative diabetic retinopathy(PDR). Methods  The clinicaldata were retrospectively analyzed in 32 eyes of 31 patients for PDR treated with an intravitreal  injection of 0.1mL/2.5mg Avastin 5-7 days before the operation, then a normal three-way vitrectomy was made on all the patients, and phacoemulsification and intraocular lens implantation were combined for 16 patients with cataract. Results  Originally active neovascularization decreased or ended, hemorrhage decreased in stripping and cutting the membrane, and stripping the membrane became easier than before. In a follow up of 3 months, visual acuity increased in 26 eyes(81.3%), was unchanged in 5 eyes(15.6%), and decreased in 1 eye(3.1%). No severe complications were found. Conclusion  Avastin can significantly makevitrectomy easy,reduce the risks of hemorrhage and improve visual acuity of patients, but the safety and availability need a long-term and large sample clinical observation.

Key words: Proliferative diabetic retinopathy; Avastin; Vitrectomy