Abstract: Objective To observe clinical effect of the stromal layer of fluconazole injection of fungal keratitis. Methods 70 eyes diagnosed as fungal keratitis were randomly divided to two groups with 35 eyes in each. The treatment group was firstly treated helcoma with stomal layer of fluconazole injection, then treated with fluconazole eye ointment and recombinant bovine basic fibroblast growth factor gel enveloping eyes. The control group was firstly treated helcoma with iodine cautery and then used fluconazole eye ointment and recombinant bovine basic fibroblast growth factor gel enveloping eyes. The clinical feasibility of iodine cautery and the stromal layer of fluconazole injection in the treatment of fungal keratitis were observed and compared. Results Thirty-five eyes in the treatment group used the stromal layer of fluconazole injection, all helcoma healed up. The course was shorten and the effect was better than the control group(P<0.05).The average visual acuity of two groups before and after treatment was statistical different(P<0.05). Conclusion Corneal stromal layer injection in the treatment of fungal keratitis can enhance the curative rate obviously. It is an effective and safe therapeutic method.

Key words: Povidone iodine, Corneal stronmal layer injection, Fluconazole injection, Fungal keratitis