JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (5): 79-82.doi: 10.6040/j.issn.1673-3770.0.2015.170

Previous Articles     Next Articles

Research progress of miRNA in head and neck cancers

ZHOU Juan, ZHENG Jiafa   

  1. Department of Otorhinolaryngology Head and Neck Surgery, Nanhua Hospital Affiliated to University of South China, Hengyang 421001, Hunan, China
  • Received:2015-04-24 Revised:2015-09-22 Online:2015-10-16 Published:2015-10-16

PDF (PC)

748

Abstract: A microRNA, abbreviated miRNA, is a non-coding single-stranded small molecular RNA. Through incomplete or complete complementary pairing with target mRNA 3' UTR (3' end untranslated region), it plays an important role in the occurrence and development of tumors. This paper reviews the role of miRNA in the diagnosis, prognosis and treatment of head and neck cancers.

Key words: Head and neck cancers, miRNA, Gene

CLC Number: 

  • R739.91
[1] Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer[J]. Oral Oncol, 2009, 45(4-5): 309-316.
[2] Nagadia R, Pandit P, Coman W B, et al. miRNAs in head and neck cancer revisited[J]. Cell Oncol (Dordr), 2013, 36(1): 1-7.
[3] Warnakulasuriya S. Causes of oral cancer—an appraisal of controversies[J]. Br Dent J, 2009, 207(10): 471-475.
[4] Lee R C, Feinbaum R L, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5): 843-854.
[5] Malumbres M. miRNAs and cancer: an epigenetics view[J]. Mol Aspects Med, 2012, 34: 863-874.
[6] Li J, Huang H, Sun L, et al. MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor[J]. Clin Cancer Res, 2009, 15(12): 3998-4008.
[7] Yu Z W, Zhong L P, Ji T, et al. MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines[J]. Oral Oncol, 2010, 46(4): 317-322.
[8] Kozaki K, Imoto I, Mogi S, et al. Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer[J]. Cancer Res, 2008, 68(7): 2094-2105.
[9] Avissar M, Christensen B C, Kelsey K T, et al. MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma[J]. Clin Cancer Res, 2009, 15(8): 2850-2855.
[10] 张春妮, 张辰宇. 体液microRNA作为新的无创伤性生物标志物的意义[J]. 分子诊断与治疗杂志, 2011, 3(3): 145-151. ZHANG Chunni, ZHANG Chenyu. The significance of humoral microRNA as a new biomarker for noninvasive biological[J]. J Mole Diagn Ther, 2011, 3(3): 145-151.
[11] 孙伟, 史冬泉, 蒋青. 血清microRNA的检测及临床应用进展[J]. 医学综述, 2011, 17(23): 3616-3618. SUN Wei, SHI Dongquan, JIANG Qing. Progress of detection and clinical application of serum microRNA[J]. Med Survey, 2011, 17(23): 3616-3618.
[12] Liu C J, Kao S Y, Tu H F, et al. Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer[J]. Oral Dis, 2010, 16(4): 360-364.
[13] Park N J, Zhou H D, Elashoff D, et al. Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection[J]. Clin Cancer Res, 2009, 15(17): 5473-5477.
[14] Siow M Y, Karen Ng L P, Vincent Chong V K, et al. Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma[J]. Oral Dis, 2014, 20(4): 345-351.
[15] Rather M I, Nagashri M N, Swamy S S, et al. Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation: implications for cancer therapeutics[J]. J Biol Chem, 2013, 288(1): 608-618.
[16] Su J, Baigude H, McCarroll J, et al. Silencing microRNA by interfering nanoparticles in mice[J]. Nucleic Acids Res, 2011, 39(6): 38.
[17] 陈建, 王朝霞. 微小RNA: 肿瘤耐药治疗新靶点[J]. 现代肿瘤医学, 2012, 20(01): 191-196. CHEN Jian, WANG Zhaoxia. miRNA: Tumor drug resistance therapy target[J]. Mod Tumor Med, 2012, 20(1): 191-196.
[1] WANG Min, LIU Hao, JIANG Luhan, TAN Liyue, LI Wen, FU Xiaolong. Packaging of AAV-ie-Tnfaip8l2 and its effect on improving auditory function in Tnfaip8l2-/- mice [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 7-15.
[2] WU Fulian, JI Xuying. Layer-specific response distribution characteristics of binaural integration neurons in the auditory cortex and synaptic input regulation mechanism [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 7-17.
[3] ZHANG Nana, HUANG Guanjiang, LU Biaoqing. Analysis of influencing factors for laryngeal carcinogenesis and construction of a predictive model [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 29-37.
[4] LIU Yijie, LU Xiuzhen, WU Qiuxin. Research rogress of exosomes in the pathogenesis, diagnosis and treatment in ophthalmic diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 135-141.
[5] LU Jiantao, ZHONG Jie, LIU Shaofeng. Electrophysiological characteristics of deep projections from bilateral auditory cortex [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 1-7.
[6] LI Jie, SU Weina, LIN Qian, ZHANG Qishu, HOU Cheng, YANG Zhenjiao, XIANG Lili. Genetic analysis of MARVELD2 gene variants in two deafness cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 128-134.
[7] DOU Tao, DOU Naixin, WANG Ru, YANG Qian, GUAN Qingbo, WANG Lei, YU Chunxiao. Bioinformatic analysis of miRNA-mRNA network involved in thyroid function impairment by high-fat diet [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 151-160.
[8] WANG Yao, CHEN Jingyi, YANG Yingchao, SU Kaiming. Adenotonsillectomy in a child with congenital fibrinogen deficiency and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 77-80.
[9] ZHANG Lixia, LI Lin. Research on screening the key genes of age-related hearing loss by GEO database [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 104-114.
[10] MAO Yiheng, FENG Jie, HE Runtian. Study on the relationship between the effects of hyperlipidemia on retinal damage and choroid thickness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 162-167.
[11] PAN Jiayu, ZHANG Chunlin. Research advances on the etiology and pathogenesis of acute low-frequency sensorineural hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 126-131.
[12] WANG Boshen, LENG Hui, SUN Haibo. Co-expressing genes in Meniere's disease and vestibular migraine and molecular docking prediction of gastrodin [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 29-40.
[13] XU Wanjing, SUN Yuhao, ZHAO Jun. Effects of antioxidant activity of curcumin in retinal degenerative diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 146-151.
[14] YANG Songyue, ZHANG Meixia. Advances in single-cell RNA sequencing in the retina [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 162-170.
[15] WU Wei, WANG Lei, CHEN Sheng, LI Lianyong, WANG Gang. Multidisciplinary research and advances in gastro-oesophageal reflux disease [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 1-14.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd