JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (3): 10-14.doi: 10.6040/j.issn.1673-3770.0.2016.222

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Preliminary clinical analysis of neo-adjuvant chemotherapy with nimotuzumab plus nedaplatin and fluorouracil in hypopharyngeal squamous cell carcinoma.

DONG Pin1, YING Xinjiang1, CHEN Xinwei1, DENG Zhihong2, ZHANG Shaoqiang3, YU Ziwei1, JIN Bin1, SUN Zhenfeng1, XIE Jin1, ZHU Jiangcai   

  1. Department of Otolaryngology &Head and Neck Surgery, 1.Shanghai General Hospital of Shanghai Jiaotong University, Shanghai 200080, China;2.Xijing Hospital of Affiliated to The Forth Military Medical University, Xian 710032, Shaanxi, China;3.The First Affiliated Hospital of Xian Jiaotong University, Xian 710061, Shaanxi, China
  • Received:2016-05-22 Online:2016-06-16 Published:2016-06-16

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Abstract: Objective To investigate the safety and efficacy of nimotuzumab combined with nedaplatinand and fluorouracil(5-FU)as neo-adjuvant chemotherapy in the treatment of hypopharyngeal squamous cell carcinoma. Methods Between July 2012 and December 2014, we performed initial treatment on 91 cases of hypopharyngeal squamous cell carcinoma with the nimotuzumab(300 mg/m2 day 1)combined with nedaplatin(90 mg/m2 day 1)and 5-FU(750 mg/m2 day1-5)as neo-adjuvant chemotherapy, with one cycle for 3 weeks. Two cycles were followed by surgery and radiation therapy. The primary endpoint was tumor response rate, pathological complete response rate, the rate of laryngeal preservation and chemotherapy related toxicity. Results The response rate of tumor was 86.8%(79/91)after two cycles of neo-adjuvant chemotherapy. Fifty-two patients(57.1%)got downstage, with T downstage in 47(51.6%)cases and N downstage in 20(22.0%)cases. Eighty-eight patients got surgery after the neo-adjuvant chemotherapy, of which 68 patients(77.3%)preserved laryngeal function. The pathological complete response was 8.8%(8/91)of the total. The toxicity was mild and manageable. There were 29 cases of neutropenia(31.9%), 26 cases of nausea/vomiting(28.6%). Conclusion Nimotuzumab plus nedaplatin and 5-FU regimen as neo-adjuvant chemotherapy was highly effective for improving the hypopharyngeal carcinoma patients’ tumor response rate and preserving their organ function, while the toxicities were well tolerable.

Key words: Receptor, epidermal growth factor, Target, Neo-adjuvant Chemotherapy, Hypopharyngeal cancer, squamous cell carcinoma

CLC Number: 

  • R739.63
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