儿童扁桃体微生物群与免疫调节及疾病关联

doi:10.6040/j.issn.1673-3770.0.2025.230

Abstract

Abstract: The dynamic balance and diversity of the tonsillar microbiota constitute a core component of the upper respiratory immune defense system in children. Therefore, in-depth analysis of the composition and functions of the tonsillar microbiota is imperative for maintaining optimal pediatric health. Traditional culture techniques can detect a limited range of pathogenic bacteria, but are inherently restricted by the spectrum of culturable microorganisms. In contrast, 16S rRNA gene sequencing has the potential to overcome these limitations, offering a novel and comprehensive perspective for profiling the microbiota.This article systematically reviews the current advances in detection technologies, characteristics of core microbial communities, genetic and environmental influencing factors, causal relationships between microbiota dysbiosis and disease, and clinical intervention strategies based on microbiota modulation in pediatric tonsils. This review aims to provide a theoretical basis for the precision diagnosis, treatment, and health management of pediatric tonsillar diseases, and to guide future research into the interaction mechanisms between the tonsillar microbiota and host immunity.

Key words: Tonsillar microbiota, Pediatric immunity, Microbial dysbiosis, 16S rRNA sequencing, Respiratory tract infections

CLC Number:

R766.18

YUE Bingyan, ZOU Jian, LEI Lei, WEN Qiao, QIAN Yingxue. Tonsillar microbiota of children, immune regulation and diseases[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 193-200.

References 72

[1]	Yoon A, Abdelwahab M, Bockow R, et al. Impact of rapid palatal expansion on the size of adenoids and tonsils in children[J]. Sleep Med, 2022, 92: 96-102. doi: 10.1016/j.sleep.2022.02.011
[2]	左路杰, 耿江桥, 赫莉, 等. 388例儿童扁桃体肥大细菌学分析[J]. 中国耳鼻咽喉头颈外科, 2023, 30(8): 515-518, 526. doi:10.16066/j.1672-7002.2023.08.009
[3]	ZUO Lujie,GENG Jiangqiao,HE Li,et al.Bacteriological analysis of 388 children with tonsil hypertrophy[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2023, 30(8): 515-518, 526. doi:10.16066/j.1672-7002.2023.08.009
[4]	梁乐平, 赵倩倩. 急性化脓性扁桃体炎患者咽部菌群特征[J]. 中国微生态学杂志, 2021, 33(11): 1321-1325. doi: 10.13381/j.cnki.cjm.202111017 LIANG Leping, ZHAO Qianqian. The microbial characteristics of pharyngeal flora in patients with acute suppurative tonsillitis[J]. Chinese Journal of Microecology, 2021, 33(11): 1321-1325. doi: 10.13381/j.cnki.cjm.202111017
	Erdélyi E, Ambrus A, Szabó L, et al. The role of microbiological examination in treating peritonsillar abscess based on the retrospective analysis of data from six years[J]. Orv Hetil, 2020, 161(44): 1877-1883. doi: 10.1556/650.2020.31843
[5]	王英琪. 单细胞转录组测序技术在儿童扁桃体和腺样体B细胞研究中应用的初步探讨[D]. 广州: 广州医科大学, 2020
[6]	Dickinson A, Kankaanpää H, Silén S, et al. Tonsillar surface swab bacterial culture results differ from those of the tonsillar core in recurrent tonsillitis[J]. Laryngoscope, 2020, 130(12): 791-794. doi: 10.1002/lary.28403
[7]	买尔给娜·努尔太. 慢性扁桃体炎表面细菌学及核心细菌学比较[D]. 乌鲁木齐: 新疆医科大学, 2023
[8]	Lloréns-Rico V, Vieira-Silva S, Gonçalves PJ, et al. Benchmarking microbiome transformations favors experimental quantitative approaches to address compositionality and sampling depth biases[J]. Nat Commun, 2021, 12: 3562. doi: 10.1038/s41467-021-23821-6
[9]	Pallon J, Sundqvist M, Rööst M, et al. Presence of microorganisms in children with pharyngotonsillitis and healthy controls: a prospective study in primary healthcare[J]. Infection, 2021, 49(4): 715-724. doi: 10.1007/s15010-021-01595-9
[10]	Stivala A, Genovese C, Bonaccorso C, et al. Comparison of cell culture with three conventional polymerase chain reactions for detecting Chlamydophila pneumoniae in adult's pharyngotonsillitis[J]. Curr Microbiol, 2020, 77(10): 2841-2846. doi: 10.1007/s00284-020-02106-z
[11]	Regueira-Iglesias A, Balsa-Castro C, Blanco-Pintos T, et al. Critical review of 16S rRNA gene sequencing workflow in microbiome studies: from primer selection to advanced data analysis[J]. Mol Oral Microbiol, 2023, 38(5): 347-399. doi: 10.1111/omi.12434
[12]	Kumaishi K, Usui E, Suzuki K, et al. High throughput method of 16S rRNA gene sequencing library preparation for plant root microbial community profiling[J]. Sci Rep, 2022, 12(1): 19289. doi: 10.1038/s41598-022-23943-x
[13]	Dueholm MS, Andersen KS, McIlroy SJ, et al. Generation of comprehensive ecosystem-specific reference databases with species-level resolution by high-throughput full-length 16S rRNA gene sequencing and automated taxonomy assignment(AutoTax)[J]. mBio, 2020, 11(5): e01557-20. doi: 10.1128/mBio.01557-20
[14]	Bi YW, Yang QY, Li J, et al. The gut microbiota and inflammatory factors in pediatric appendicitis[J]. Dis Markers, 2022, 2022: 1059445. doi: 10.1155/2022/1059445
[15]	Zhang WK, Fan XQ, Shi HB, et al. Comprehensive assessment of 16S rRNA gene amplicon sequencing for microbiome profiling across multiple habitats[J]. Microbiol Spectr, 2023, 11(3): e0056323. doi: 10.1128/spectrum.00563-23
[16]	Brinkrolf K, Schneider J, Knecht M, et al. Draft genome sequence of Turicella otitidis ATCC 51513, isolated from middle ear fluid from a child with otitis media[J]. J Bacteriol, 2012, 194(21): 5968-5969. doi: 10.1128/JB.01412-12
[17]	Song YP, Hou JP, Kwok JSL, et al. Whole-genome shotgun sequencing for nasopharyngeal microbiome in pre-school children with recurrent wheezing[J]. Front Microbiol, 2022, 12: 792556. doi: 10.3389/fmicb.2021.792556
[18]	Nygren D, Brorson E, Musonda M, et al. Geographical differences in tonsillar carriage rates of Fusobacterium necrophorum-A cross-sectional study in Sweden and Zambia[J]. Anaerobe, 2021, 69: 102360. doi: 10.1016/j.anaerobe.2021.102360
[19]	赵伟亚. 呼吸道感染儿童与健康儿童口咽部菌群差异性分析[D]. 石家庄: 河北医科大学, 2021
[20]	Han YM, Wang BY, Gao H, et al. Insight into the relationship between oral microbiota and the inflammatory bowel disease[J]. Microorganisms, 2022, 10(9): 1868. doi: 10.3390/microorganisms10091868
[21]	Wu SR, Hammarstedt-Nordenvall L, Jangard M, et al. Tonsillar microbiota: a cross-sectional study of patients with chronic tonsillitis or tonsillar hypertrophy[J]. mSystems, 2021, 6(2): e01302-20. doi: 10.1128/mSystems.01302-20
[22]	王志远, 姜美妍, 赵海, 等. 不同年龄段慢性扁桃体炎患者菌群差异及药敏学分析[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(13): 1027-1029. doi: 10.13201/j.issn.1001-1781.2018.13.017 WANG Zhiyuan, JIANG Meiyan, ZHAO Hai, et al. The bacterial flora and drug sensitivity of chronic tonsillitis in different age groups[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(13): 1027-1029. doi: 10.13201/j.issn.1001-1781.2018.13.017
[23]	宋晓蕊, 许莹, 僧东杰, 等. 腺样体和扁桃体菌群研究进展[J]. 中华耳鼻咽喉头颈外科杂志, 2021, 56(8): 885-890. doi:10.3760/cma.j.cn115330-20201009-00792 SONG Xiaorui, XU Ying, SENG Dongjie, et al. Advances in adenotonsillar microbiome[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2021, 56(8): 885-890. doi:10.3760/cma.j.cn115330-20201009-00792
[24]	Klug TE, Greve T, Caulley L, et al. The impact of social restrictions on the incidence and microbiology of peritonsillar abscess: a retrospective cohort study[J]. Clin Microbiol Infect, 2024, 30(1): 100-106. doi: 10.1016/j.cmi.2023.08.003
[25]	Zhang XM, Li XY, Xu HJ, et al. Changes in the oral and nasal microbiota in pediatric obstructive sleep apnea[J]. J Oral Microbiol, 2023, 15(1): 2182571. doi: 10.1080/20002297.2023.2182571
[26]	Xu H, Tian BJ, Shi WH, et al. A correlation study of the microbiota between oral cavity and tonsils in children with tonsillar hypertrophy[J]. Front Cell Infect Microbiol, 2022, 11: 724142. doi: 10.3389/fcimb.2021.724142
[27]	Chuang HH, Hsu JF, Chuang LP, et al. Different associations between tonsil microbiome, chronic tonsillitis, and intermittent hypoxemia among obstructive sleep apnea children of different weight status: a pilot case-control study[J]. J Pers Med, 2021, 11(6): 486. doi: 10.3390/jpm11060486
[28]	Prates MCM, Tamashiro E, Proenca-Modena JL, et al. The relationship between colonization by Moraxella catarrhalis and tonsillar hypertrophy[J]. Can J Infect Dis Med Microbiol, 2018, 2018: 5406467. doi: 10.1155/2018/5406467
[29]	Abbas AM, Rasheed AM, Hilal SA, et al. Histopathological tracing of HPV genotypes 6 and 11 in pediatric patients in medical city with chronic palatine and pharyngeal tonsillitis[J]. Clin Lab, 2024, 70(1). doi: 10.7754/Clin.Lab.2023.230615
[30]	Onal M, Kocak N, Duymus F, et al. Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study[J]. Mol Biol Rep, 2021, 48(7): 5579-5586. doi: 10.1007/s11033-021-06579-4
[31]	Sweerus K, Lachowicz-Scroggins M, Gordon E, et al. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma[J]. J Allergy Clin Immunol, 2017, 139(1): 72-81.e1. doi: 10.1016/j.jaci.2016.02.035
[32]	Nurjadi D, Herrmann E, Hinderberger I, et al. Impaired β-defensin expression in human skin links DEFB1 promoter polymorphisms with persistent Staphylococcus aureus nasal carriage[J]. J Infect Dis, 2013, 207(4): 666-674. doi: 10.1093/infdis/jis735
[33]	Medhasi S, Chantratita N. Human leukocyte antigen(HLA)system: genetics and association with bacterial and viral infections[J]. J Immunol Res, 2022, 2022: 9710376. doi: 10.1155/2022/9710376
[34]	Wilks J, Beilinson H, Golovkina TV. Dual role of commensal bacteria in viral infections[J]. Immunol Rev, 2013, 255(1): 222-229. doi: 10.1111/imr.12097
[35]	Cosin-Tomas M, Cilleros-Portet A, Aguilar-Lacasaña S, et al. Prenatal maternal smoke, DNA methylation, and multi-omics of tissues and child health[J]. Curr Environ Health Rep, 2022, 9(3): 502-512. doi: 10.1007/s40572-022-00361-9
[36]	霍秀云, 朱珊. 基于“虚气留滞” 理论探讨儿童慢性扁桃体炎的病因病机[J]. 中国民间疗法, 2021, 29(15): 11-14. doi: 10.19621/j.cnki.11-3555/r.2021.1504
[37]	周昌莉. 慢性扁桃体炎疾病中IL-4、TNF-α、Foxp3、CTLA-4的表达及临床意义[D]. 合肥: 安徽医科大学, 2017
[38]	闫树学, 王璇, 马晓花, 等. 芩翘口服液联合头孢克肟治疗小儿急性扁桃体炎的临床研究[J]. 现代药物与临床, 2023, 38(6): 1407-1411. doi: 10.7501/j.issn.1674-5515.2023.06.018 YAN Shuxue, WANG Xuan, MA Xiaohua, et al. Clinical study of Qinqiao Oral Liquid combined with cefixime in treatment of acute tonsillitis in children[J]. Drugs & Clinic, 2023, 38(6): 1407-1411. doi: 10.7501/j.issn.1674-5515.2023.06.018
[39]	Galli J, Calò L, Posteraro B, et al. Pediatric oropharyngeal microbiome: Mapping in chronic tonsillitis and tonsillar hypertrophy[J]. Int J Pediatr Otorhinolaryngol, 2020, 139: 110478. doi: 10.1016/j.ijporl.2020.110478
[40]	周思平, 陶波, 张勇辉, 等. 儿童慢性扁桃体炎发病因素的列线图预测模型构建与评价[J]. 中国当代医药, 2024, 31(28): 65-69. doi: 10.3969/j.issn.1674-4721.2024.28.016 ZHOU Siping, TAO Bo, ZHANG Yonghui, et al. Construction and evaluation of nomogram prediction model for pathogenic factors of chronic tonsillitis in children[J]. China Modern Medicine, 2024, 31(28): 65-69. doi: 10.3969/j.issn.1674-4721.2024.28.016
[41]	王慧君, 李彦如, 郜飞, 等. OSA患病儿童的家庭遗传及环境危险因素分析[J]. 临床耳鼻咽喉头颈外科杂志, 2020, 34(8): 678-682. doi:10.13201/j.issn.2096-7993.2020.08.002 WANG Huijun, LI Yanru, GAO Fei, et al. Analysis of genetic and environmental risk factors in pediatric OSA[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2020, 34(8): 678-682. doi:10.13201/j.issn.2096-7993.2020.08.002
[42]	牛娟萍, 赵娟. 口腔护理联合健康宣教在小儿急性化脓性扁桃体炎中的干预效果[J]. 母婴世界, 2024(13): 223-225
[43]	Modrzyński M, Zawisza E. Frequency of adenoid hypertrophy in children with allergic diseases[J]. Przegl Lek, 2003, 60(5): 322-324
[44]	Park J, Lee KE, Choi DH, et al. The association of tonsillar microbiota with biochemical indices based on obesity and tonsillar hypertrophy in children[J]. Sci Rep, 2023, 13: 22716. doi: 10.1038/s41598-023-49871-y
[45]	Meade KG, O'Farrelly C. β-defensins: farming the microbiome for homeostasis and health[J]. Front Immunol, 2019, 9: 3072. doi: 10.3389/fimmu.2018.03072
[46]	Wassing GM, Ilehag N, Frey J, et al. Modulation of human beta-defensin 2 expression by pathogenic Neisseria meningitidis and commensal lactobacilli[J]. Antimicrob Agents Chemother, 2021, 65(4): e02002-20. doi: 10.1128/AAC.02002-20
[47]	Niedzielski A, Chmielik LP, Mielnik-Niedzielska G, et al. Adenoid hypertrophy in children: a narrative review of pathogenesis and clinical relevance[J]. BMJ Paediatr Open, 2023, 7(1): e001710. doi: 10.1136/bmjpo-2022-001710
[48]	孙梦玲, 牛勋, 杨修平, 等. EB病毒与儿童扁桃体腺样体肥大的相关研究现状[J]. 临床耳鼻咽喉头颈外科杂志, 2021, 35(5): 477-480. doi: 10.13201/j.issn.2096-7993.2021.05.022 SUN Mengling, NIU Xun, YANG Xiuping, et al. Research status of Epstein Barr virus in children with adenotonsillar hypertrophy[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2021, 35(5): 477-480. doi: 10.13201/j.issn.2096-7993.2021.05.022
[49]	卢根, 成焕吉. A族链球菌感染与呼吸道感染[J]. 中华实用儿科临床杂志, 2022, 37(21): 1622-1625. doi:10.3760/cma.j.cn101070-20220520-00582 LU Gen, CHENG Huanji. Group A Streptococcus infection and respiratory tract infection[J]. Chinese Journal of Applied Clinical Pediatrics, 2022, 37(21): 1622-1625. doi:10.3760/cma.j.cn101070-20220520-00582
[50]	刘珊彤, 曹志伟, 赵鹤, 等. 腺样体/扁桃体肥大患儿手术治疗前后血常规检查指标对比观察[J]. 山东医药, 2021, 61(12): 57-60. doi: 10.3969/j.issn.1002-266X.2021.12.014
[51]	Stelter K. Tonsillitis and sore throat in children[J]. GMS Curr Top Otorhinolaryngol Head Neck Surg, 2014, 13: Doc07. doi: 10.3205/cto000110
[52]	梁乐平, 赵倩倩. 急性化脓性扁桃体炎患者咽部菌群特征[J]. 中国微生态学杂志, 2021, 33(11): 1321-1325. doi: 10.13381/j.cnki.cjm.202111017 LIANG Leping, ZHAO Qianqian. The microbial characteristics of pharyngeal flora in patients with acute suppurative tonsillitis[J]. Chinese Journal of Microecology, 2021, 33(11): 1321-1325. doi: 10.13381/j.cnki.cjm.202111017
[53]	Tagg JR, Harold LK, Jain R, et al. Beneficial modulation of human health in the oral cavity and beyond using bacteriocin-like inhibitory substance-producing streptococcal probiotics[J]. Front Microbiol, 2023, 14: 1161155. doi: 10.3389/fmicb.2023.1161155
[54]	Mansson A, Adner M, Cardell LO. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis[J]. Respir Res, 2006, 7(1): 36. doi: 10.1186/1465-9921-7-36
[55]	Li J, Li SH, Jin JY, et al. The aberrant tonsillar microbiota modulates autoimmune responses in rheumatoid arthritis[J]. JCI Insight, 2024, 9(18): e175916. doi: 10.1172/jci.insight.175916
[56]	Wang LL, Xu DG, Huang Q, et al. Characterization of tonsil microbiota and their effect on adenovirus reactivation in tonsillectomy samples[J]. Microbiol Spectr, 2021, 9(2): e0124621. doi: 10.1128/Spectrum.01246-21
[57]	Li J, Jin JY, Li SH, et al. Tonsillar microbiome-derived lantibiotics induce structural changes of IL-6 and IL-21 receptors and modulate host immunity[J]. Adv Sci(Weinh), 2022, 9(30): e2202706. doi: 10.1002/advs.202202706
[58]	Yu ZH, Xu ZY, Fu TT, et al. Parallel comparison of T cell and B cell subpopulations of adenoid hypertrophy and tonsil hypertrophy of children[J]. Nat Commun, 2025, 16(1): 3516. doi: 10.1038/s41467-025-58094-w
[59]	Zuo LJ, He L, Huang AP, et al. Risk factors and antibiotic sensitivity of aerobic bacteria in Chinese children with adenoid hypertrophy[J]. BMC Pediatr, 2022, 22(1): 553. doi: 10.1186/s12887-022-03613-7
[60]	Hale JDF, Jain R, Wescombe PA, et al. Safety assessment of Streptococcus salivarius M18 a probiotic for oral health[J]. Benef Microbes, 2022, 13(1): 47-60. doi: 10.3920/bm2021.0107
[61]	Chandrasekhar SN, Mallikarjun SB, Salim HP. Comparative evaluation of antibacterial activity of probiotics SK12 and SM18: an in vitro study[J]. Int J Clin Pediatr Dent, 2020, 13(6): 611-616. doi: 10.5005/jp-journals-10005-1838
[62]	Chen TY, Hale JDF, Tagg JR, et al. In vitro inhibition of clinical isolates of otitis media pathogens by the probiotic Streptococcus salivarius BLIS K12[J]. Probiotics Antimicrob Proteins, 2021, 13(3): 734-738. doi: 10.1007/s12602-020-09719-7
[63]	Laws GL, Hale JDF, Kemp RA. Human systemic immune response to ingestion of the oral probiotic Streptococcus salivarius BLIS K12[J]. Probiotics Antimicrob Proteins, 2021, 13(6): 1521-1529. doi: 10.1007/s12602-021-09822-3
[64]	Abou-Elkhair R, Ahmed H, Ketkat S, et al. Supplementation of a low-protein diet with tryptophan, threonine, and valine and its impact on growth performance, blood biochemical constituents, immune parameters, and carcass traits in broiler chickens[J]. Vet World, 2020, 13(6): 1234-1244. doi: 10.14202/vetworld.2020.1234-1244
[65]	农光耀, 黄正泉, 梁光照, 等. 不同手术方式治疗儿童慢性扁桃体炎临床疗效及T淋巴细胞亚群变化[J]. 临床军医杂志, 2021, 49(8): 937-939. doi:10.16680/j.1671-3826.2021.08.31
[66]	Ji JG, Sundquist J, Sundquist K. Tonsillectomy associated with an increased risk of autoimmune diseases: a national cohort study[J]. J Autoimmun, 2016, 72: 1-7. doi: 10.1016/j.jaut.2016.06.007
[67]	Di Pierro F, Colombo M, Zanvit A, et al. Use of Streptococcus salivarius K12 in the prevention of streptococcal and viral pharyngotonsillitis in children[J]. Drug Healthc Patient Saf, 2014: 15. doi: 10.2147/dhps.s59665
[68]	杨洋, 胡付品, 朱德妹. 儿童急性化脓性扁桃体炎和急性鼻窦炎的病原菌分布及药物敏感性[J]. 中国感染与化疗杂志, 2015, 15(4): 316-323. doi: 10.16718/j.1009-7708.2015.04.025 YANG Yang, HU Fupin, ZHU Demei. Distribution and susceptibility to cefditoren of pathogens causing acute suppurative tonsillitis and acute sinusitis in children[J]. Chinese Journal of Infection and Chemotherapy, 2015, 15(4): 316-323. doi: 10.16718/j.1009-7708.2015.04.025
[69]	岳磊, 刘云, 袁果, 等. 病原微生物与菌群特征在预测和诊断化脓性扁桃体炎的价值研究[J]. 中国病原生物学杂志, 2025, 20(4): 455-459. doi: 10.13350/j.cjpb.250409 YUE Lei, LIU Yun, YUAN Guo, et al. Clinical investigation of pathogenic microorganisms and bacterial flora characteristics for the prediction and diagnosis of suppurative tonsillitis[J]. Journal of Pathogen Biology, 2025, 20(4): 455-459. doi: 10.13350/j.cjpb.250409
[70]	Wang LL, Xu DG, Huang Q, et al. Characterization of tonsil microbiota and their effect on adenovirus reactivation in tonsillectomy samples[J]. Microbiol Spectr, 2021, 9(2): e0124621. doi: 10.1128/Spectrum.01246-21
[71]	Cavalcanti VP, Camargo LA, Moura FS, et al. Staphylococcus aureus in tonsils of patients with recurrent tonsillitis: prevalence, susceptibility profile, and genotypic characterization[J]. Braz J Infect Dis, 2019, 23(1): 8-14. doi: 10.1016/j.bjid.2018.12.003
[72]	Münch PC, Franzosa EA, Stecher B, et al. Identification of natural CRISPR systems and targets in the human microbiome[J]. Cell Host Microbe, 2021, 29(1): 94-106. doi: 10.1016/j.chom.2020.10.010

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Tonsillar microbiota of children, immune regulation and diseases

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