鼻内疫苗在鼻咽相关淋巴组织中的免疫机制及临床应用

doi:10.6040/j.issn.1673-3770.0.2024.499

Abstract

Abstract: Intranasal vaccines are used to prevent respiratory infectious diseases by inducing local mucosal and systemic immune responses through action on nasopharyngeal-associated lymphoid tissue and have demonstrated potential for the treatment of brain and autoimmune diseases. Intranasal vaccines combined with new adjuvants and delivery systems can significantly enhance antigen immunogenicity and have shown initial results in the prevention of diseases such as influenza and new coronaviruses. On the contrary, tonsil-like organs, as an emerging three-dimensional experimental model, can accurately mimic the immune microenvironment and provide new tools for vaccine evaluation and design optimization. This article reviews the progress of intranasal vaccine research in clinical applications and analyzes the role of novel adjuvants, delivery systems, and tonsil-like organs in their optimization, with the aim of providing theoretical support for the development and application of intranasal vaccines in the future.

Key words: Nasopharyngeal-related lymphoid tissue, Intranasal vaccine, Adjuvant, Drug delivery system, Tonsil organoids

CLC Number:

R392.3

FU Lijun, WANG Haiyang, WANG Yuqi, ZOU Yuhao, ZOU Jian. Immune mechanism and clinical application of the intranasal vaccine in nasopharyngeal-associated lymphoid tissues[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 93-99.

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Immune mechanism and clinical application of the intranasal vaccine in nasopharyngeal-associated lymphoid tissues

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