Abstract: Objective To analyze the factors affecting the detection of quantitative visual assessment in infants, extract clinical experience, and improve detection rates. Methods This prospective observational study included 240 infants(0-36 months)who visited the pediatric fundus clinic at Shenzhen Eye Hospital between November 2022 and February 2024. Two examiners with different levels of experience conducted quantitative visual assessments, recording the basic characteristics, initial visual target selection, cooperation level, and preparation status of each child. A logistic regression model was used to identify factors influencing the detection of quantitative visual assessment. Based on these factors, a receiver operating characteristic(ROC)curve was used to develop a nomogram prediction model, with calibration evaluated using the Hosmer-Lemeshow(H-L)test and calibration curves. Results This study included 240 infants. Univariate logistic regression analysis identified effective initial visual targets(OR=119.182, 95%CI:45.904-309.435), high level of cooperation(OR=14.806, 95%CI:7.014-31.256)and thorough preparation(OR=182.668, 95%CI:25.166-1 325.898)as positive influencing factors for higher detection rates. In contrast, the presence of eye disease(OR=0.178, 95%CI:0.093-0.338)and premature birth(OR=0.329, 95%CI:0.184-0.586)were negative influencing factors, associated with lower detection rates. These differences were statistically significant. Multivariate regression analysis, including statistically significant factors, indicated that effective initial visual targets(OR=23.340, 95%CI:2.973-183.243), cooperation level(OR=20.380, 95%CI:2.859-145.278)and thorough preparation(OR=1 380.262, 95%CI:130.876-61 702.162)were key factors influencing the detection of quantitative visual assessment in infants. The analysis of the ROC curve revealed that the area under the curve(AUC)of the prediction model was 0.995(95%CI:0.991-1.000), with a sensitivity of 95.00%, specificity of 100% and precision of 96.60%. Conclusion The detection rate of quantitative visual assessment in infants is influenced by multiple factors. To improve detection rates in clinical practice, it is essential to ensure thorough preparation, select effective initial visual targets, and enhance the level of cooperation of infants.

Key words: Infants, Quantitative Visual Acuity Assessment, Qualitative Visual Acuity Assessment, Receiver operating characteristic, Detection Rate of Quantitative Visual Assessment