JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2012, Vol. 26 ›› Issue (3): 10-12.

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Effect of ambroxol hydrochloride on secretory otitis media： A  meta-analysis

HOU  Sen1， YANG  Hai-zhen2   

  1. 1. Department of Otorhinolaryngology, 2. Department of Pathology,Yanggu People′s Hospital, Yanggu 252300, Shandong, China
  • Received:2012-02-26 Online:2012-06-16 Published:2012-06-16

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Abstract:

Objective   To evaluate the effects of ambroxol hydrochloride on secretory otitis media. Methods   Randomized, controlled trials(RCT) of ambroxol hydrochloride in the treatment of secretory otitis media, published in Pubmed, CNKI and Wanfang databases, were collected. The methodological quality of the trials and the valid data were evaluated by Meta-analysis. Results   14 RCT and 1412 patients were included in this study. Meta analysis showed that the treatment group was better than the control. The general OR and 95%CI for the overall efficacy was 2.74(2.103.57). Conclusion   Ambroxol hydrochloride can improve the treatment of secretory otitis media，however, there were still some side effects found in the large sample, multi-center study.

Key words: Ambroxol Hydrochloride; Secretory otitis media; Meta-analysis

CLC Number: 

  • R764.1
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