J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (6): 72-73.doi: 10.6040/j.issn.1673-3770.0.2013.249

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The clinical efficacy of systemic corticosteroids and thalidomide for oropharyngeal major recurrent aphthous ulcer

WANG Wei-zhi1, ZHANG Bing-feng2, LIU Shao-hua1, WANG Xin2   

  1. 1. Department of Stomatology, Qilu Hospital of Shandong University; 2. The Key Laboratory of Otorhinolaryngology of Health Ministy, Shandong University, Jinan 250012, China
  • Received:2013-08-30 Published:2013-12-16

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Abstract:

Objective    To evaluate the clinical efficacy of small dose systemic corticosteroids  and  thalidomide for oropharyngeal major recurrent aphthous ulcer (MjAU). Methods    Clinical data of 50 MjAU patients (experimental group), administered orally with small doses of corticosteroids and thalidomide, and the other 42 MjAU patients (control group) treated only with middle dose corticosteroids were compared. Results        In the experimental group, the course was 15-180days(47.80±38.79) and  the ulcers were healed after 14-41days(22.12±7.39)treatment. In the control group, the course was 12-145days(44.62±36.03)and the ulcers  were healed after 12-36 days(19.77±8.92)medication. There was no significance between the two groups(P>0.05). Conclusion    Combination of small dose systemic corticosteroids and thalidomide shows similar efficacy as middle dose systemic corticosteroids in the treatment of oropharyngeal MjAU.

Key words: Major recurrent aphthous ulcer, Thalidomide, Corticosteroid

CLC Number: 

  • R781.5
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