JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

Previous Articles     Next Articles

MGMT gene associated with head and neck cancer

JIA Chuan-liang1,2， ZHANG  Li-jing2,3, SONG Xi-cheng2   

  1. 1. Binzhou Medical University， Yantai 264000, Shandong, China;  2. Department of Otolaryngology ＆ Head and Neck Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University， Yantai 264000， Shandong, China; 3. Medical College of Qingdao University， Qingdao 266000， Shandong, China
  • Received:2013-12-11 Online:2014-06-16 Published:2014-06-16

PDF (PC)

733

Abstract: As a main repair enzyme of DNA alkyl damage， the protein O6-methylguanine-DNA methyltransferase protects genes from mutation and carcinogenicity caused by alkylating. MGMT epigenetic regulation is the principal mechanism affecting its expression. There is a mutually contradictory issue of decreased expression of MGMT closely related to tumor occurrence and development and high expression resistant to alkylating chemotherapy.  Single nucleotide sequence mutation of this gene locus is possibly associated with cancer incidence risks. In this paper, MGMT gene researches of head and neck cancer were reviewed.

Key words: Head and neck cancer, Alkylating agent, Epigenetics, O6-methylguanine-DNA methyltransferase, Chemotherapy, Polymorphism

CLC Number: 

  • R739.1
[1] SONG Xicheng. Application value of enhanced recovery after surgery in head and neck cancer surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 1-4.
[2] ZHU Xiaocheng, QIAN Xiaoyun, GU Yajun, SHEN Xiaohui, SONG Panpan, LI Hui, GAO Xia. Expression and clinical value of MGMT and EGFR in laryngeal squamous cell carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 68-72.
[3] . Effects of concurrent chemotherapy and radiotherapy on the quality of life in children and adolescents with nasopharyngeal carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 55-58.
[4] TENG Weiqiang, CHEN Xiaoping, ZHANG Yan, ZHOU Enhui, YAO Wenhao, LI Li. Study on single nucleotide polymorphisms of partial allergic rhinitis-associated haplotype module genes. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 26-29.
[5] DONG Pin, YING Xinjiang, CHEN Xinwei, DENG Zhihong, ZHANG Shaoqiang, YU Ziwei, JIN Bin, SUN Zhenfeng, XIE Jin, ZHU Jiangcai. Preliminary clinical analysis of neo-adjuvant chemotherapy with nimotuzumab plus nedaplatin and fluorouracil in hypopharyngeal squamous cell carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 10-14.
[6] DENG Yuqin, YANG Yaqi, TAO Zezhang, KONG Yonggang, XU Yu, CHEN Shiming, XIAO Bokui.. Study on single-nucleotide polymorphisms of microRNA and susceptibility to allergic rhinitis in Han population of southern China. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 1-4.
[7] ZHOU Juan, ZHENG Jiafa. Research progress of miRNA in head and neck cancers [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 79-82.
[8] HAN Shuang, YU Dan, WEN Lianji. Application of narrow band imaging in head and neck malignant neoplasm [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(3): 86-89.
[9] ZHOU Hui, HUANG Xue-qin, HU Jun-li, YAO Jun, ZHANG Yue-fei, JIANG Feng. Experimental study on Scutellarin influence DEX in the process of chemotherapy for nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(4): 30-32.
[10] LIN Dan, DONG Wei-da, LU Mei-ping, XING Guang-qian, DONG Jia-di, ZHANG Wei-qiang. The association between rs2910164 G>C polymorphism in pre-microRNA-146a and laryngeal cancer in Jiangsu Han population [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(2): 46-50.
[11] XU Yuan-yuan, ZENG Quan, HONG Su-ling, HU Guo-hua. Comparison of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent  chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A meta analysis. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(5): 8-14.
[12] WANG Xin-ru1，2, LIU Zhi-yan3， LI Li-zhen1, HUANG Tao2, XIA Bin4, LI Fang-lin1，2. Relationship of TGF-β1G-800A and C-509T polymorphisms to susceptibility of papillary thyroid carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 28-32.
[13] QU Chen-hui1, SHOU Jian-wei1, GUO Yan1, WANG Li-jie2, YU Xiao-xu3. Clinical practice in peri-operative care of head-neck tumor in ultrasound-guided fine needle aspiration cytology [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 32-34.
[14] AN Zeng-xi, LI Xiao-yong, HOU Xiao-feng, JU Ye. 32 cases of facial and neck skin defect [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 69-70.
[15] MENG Qing-guo,LU Yong-tian,FAN Xian-liang .

Association of killer cell immunoglobulin-like receptor gene polymorphisms with nasopharyngeal carcinoma

[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 196-199 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd