JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (4): 68-72.doi: 10.6040/j.issn.1673-3770.0.2017.116

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Expression and clinical value of MGMT and EGFR in laryngeal squamous cell carcinoma.

ZHU Xiaocheng1, QIAN Xiaoyun2, GU Yajun2, SHEN Xiaohui2, SONG Panpan2, LI Hui2, GAO Xia   

  1. 1.School of Medicine, Southeast University, Nanjing 210009, Jiangsu, China;2.Department of Otolaryngology &Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China
  • Received:2017-03-17 Online:2017-08-16 Published:2017-08-16

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Abstract: Objective To investigate the relationship between expression of O6-methylguanine-DNA methyltransferase(MGMT)and epidermal growth factor receptor(EGFR)in laryngeal squamous cell carcinoma(LSCC), and their relationship with clinicopathological features. Methods We collected 103 tumor tissues, detected the expression of MGMT and EGFR by immunohistochemistry(IHC), and explored their relationship with the clinicopathological features. Results The expression of MGMT in tumor tissues was positively related to differentiation degree, T stage, and clinical stage(χ2 13.302, 8.394, 11.403, P=0.001, 0.039, and 0.010, respectively). The expression of EGFR in tumor tissue was positively correlated with T stage and clinical stage(χ2 = 14.933, 16.603, P=0.002, and 0.001, respectively). Further analysis found that the expression levels of MGMT and EGFR were positively correlated(MGMT vs EGFR χ2=5.369, P=0.019). Conclusion The expression of MGMT and EGFR was correlated with T stage and clinical stage. Detecting their expression can assist in assessing the malignancy of LSCC and guide treatment.

Key words: Epidermal growth factor receptor, Laryngeal squamous cell carcinoma, O6-Methylguanine-DNA methyltransferase

CLC Number: 

  • R739.65
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