JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (4): 30-32.doi: 10.6040/j.issn.1673-3770.0.2014.076

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Experimental study on Scutellarin influence DEX in the process of chemotherapy for nasopharyngeal carcinoma

ZHOU Hui, HUANG Xue-qin, HU Jun-li, YAO Jun, ZHANG Yue-fei, JIANG Feng   

  1. Department of Otolaryngology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China
  • Received:2014-03-06 Online:2014-08-16 Published:2014-08-16

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Abstract: Objective To investigate the influence of Scutellarin reverse that dexamethasone(DEX)interference on tumor cells-CNE-2Z by Paclitaxel chemotheraping. Methods CNE-2Z cells were treated with Paclitaxel or DEX pretreatment, or in combination with Scutellarin. The cell proliferation was measured by the MTT-assay; Expressions of Caspase-12 and Cyclin D1 were detected by RT-PCR. Results DEX reduced the effect of Paclitaxel -induced proliferation inhibition and apoptosis induction in CNE-2Z cells. But after treated by Scutellarin, the tumor cell sensitivity to Paclitaxel was partially restored. Conclusion DEX could inhibit the effect of the growth inhibition and apoptosis induction by the chemotherapeutic drugs Paclitaxel, but Scutellarin could reverse these effection and restore the sensitivity of CNE-2Z cells to Paclitaxel.

Key words: Dexamethasone, Scutellarin, desensitization, chemotherapy

CLC Number: 

  • R739.62
[1] Chen Y X, Wang Y, Fu C C, et al. Dexamethasone enhances cell resistance to chemotherapy by increasing adhesion to extracellular matrix in human ovarian cancer cells[J]. Endocr Relat Cancer, 2010, 17(1):39-50.
[2] 贺建宇, 李士英, 徐卫明, 等. 多西他赛联合奥沙利铂联合紫杉醇对晚期非小细胞肺癌化疗的临床研究[J]. 同济大学学报:医学版, 2010, 31(6):83-88.
[3] 尹满香, 张成文, 杨勇, 等. 地塞米松对紫杉醇诱导中国人肺腺癌原代细胞凋亡的影响[J]. 中国肺癌杂志, 2010, 13(1):28-33.
[4] 杨明, 钟锐生, 陈桂红. 黄芩苷对人鼻咽癌CNE-2Z细胞生长的抑制作用[J]. 广东药学院学报, 2011, 27(4):400-403.
[5] 国大亮, 何新, 刘玉璇, 等. 黄芩苷鼻用凝胶的制备及其经鼻扩散研究[J]. 药剂与工艺, 2013, 44(10):1253-1256.
[6] 文敏, 李雪, 付守廷. 黄芩苷药理作用研究新进展[J]. 沈阳药科大学学报, 2008, 25(2):158-162.
[7] 徐媛媛, 曾泉, 洪苏玲, 等. 新辅助化疗联合同期放化疗与同期放化疗单独治疗鼻咽癌疗效及安全性的Meta分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(5):8-17.
[8] Ge H, Ni S, Wang X, et al. Dexamethasone reduces sensitivity to cisplatin by blunting caspase-12-dependent cellular senescence in non-small cell lung cancer[J]. PLOS ONE, 2012, 7(12): e51821.
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