JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (3): 89-92.doi: 10.6040/j.issn.1673-3770.0.2015.530

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Influence of long-term use of prostaglandin drugs on meibomian gland function and corneal structure in patients with primary open angle glaucoma.

LI Dongmei   

  1. Department of Ophthalmology, Mianyang Wanjiang Ophthalmologic Hospital, Mianyang 621000, Sichuan, China
  • Received:2015-12-15 Online:2016-06-16 Published:2016-06-16

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Abstract: Objective To investigate the influence of prostaglandins(PGs)long-term use on meibomian gland function and corneal structure in patients with primary open angle glaucoma(POAG). Methods A total of 31 POAG patients(62 eyes)were include in this study, in which 15 cases without administration of prostaglandin drug were set as the control group; and 16 cases with long-term use of prostaglandin drugs were set as the observation group. Meibomian gland function, shape and cell density of corneal cells, status of subbasal nerve fiber bundles were compared between two groups. Results The density of basal cells, stromal cells and degree of neural distortion were significantly higher in observation group than those in the control group, and density of conjunctival goblet cell, number of branches to cornea subcutaneous nerve were significantly lower in observation group than those than the control group, with significant differences(P<0.05); there was no significnat difference in density of inflammatory cells, Langerhans cells and endothelial cell. neuronal density, and nerve luminosity variations between two groups(P>0.05). the incidence of MGD was 46.7% in the control group and was 71.9% in the observation group(P<0.05). Conclusion Long-term use of PGs may lead a meibomian gland dysfunction and damage to structure of the cornea in patients with glaucoma, including increased risk of MGD, changes in density of subcorneal cells and function of subbasal nerve fiber bundles.

Key words: Meibomian gland, Prostaglandins, Glaucoma, Corneal

CLC Number: 

  • R775
[1] 崔心瀚. 长期使用前列腺素类滴眼液对角结膜上皮的影响及维生素A对其改善作用研究[D]. 复旦大学, 2013.
[2] 白东娥, 刘伟, 季建. 抗青光眼药物对青光眼患者泪液胰岛素水平的影响及其与眼表改变的关系[J]. 眼科新进展,2013, 33(6):562-565. BAI Donge, LIU Wei, JI Jian. Effects of anti-glaucoma medicine on insulin in glaucoma tear and its relationship with ocular surface changes[J]. Rec Adv Ophthalmol, 2013, 33(6):562-565.
[3] 谢巍. 局部应用抗青光眼药物对眼部结构的影响[J]. 国际眼科杂志, 2015, 15(3):424-427. XIE Wei. Infiuence of topicai antigiaucoma medication on ocuiar surface structures[J]. Inter Eye Sci, 2015, 15(3):424-427.
[4] 武娜, 朱文卿, 孙兴怀. 前列腺素类降眼压药与角膜厚度的变薄(附1例报道)[J]. 中国眼耳鼻喉科杂志, 2012, 12(1):54-56.
[5] 华佩炎, 宣懿. 局部应用前列腺素类药物对中央角膜厚度改变的影响[J]. 国际眼科杂志, 2013, 13(1):159-160. HUA Peiyan, XUAN Yi. Effect on central corneal thickness after use of three prostaglandins[J]. Inter Eye Sci, 2013, 13(1):159-160.
[6] 韩光杰, 周和政, 张文强, 等. 有无前列腺素类药物对眼压控制的原发性开角型青光眼患者24 h眼压的影响[J]. 临床眼科杂志, 2015, 23(1):59-61. HAN Guangjie, ZHOU Hezheng, ZHANG Wenqiang, et al. The effects of prostaglandins on the 24-hour intraocular pressure in glaucoma patients[J]. J Clin Ophthalmol, 2015, 23(1):59-61.
[7] 杨立, 晋秀明. 长期使用抗青光眼药物对老年患者睑板腺功能的影响[J].中国老年学杂志, 2015, 35(10):2768-2770.
[8] Arias A, Schargel K, Ussa F, et al. Patient persistence with first-line antiglaucomatous monotherapy[J]. Clin Ophthalmol, 2010, 4:261-267.
[9] 杨洪涛.不同种类前列腺素类滴眼液治疗原发性开角型青光眼的降眼压效果对比[J]. 中国医药导报, 2014, 11(18):70-73. YANG Hongtao. Effects comparison of tree prostaglandin eyedrops in reducing open-angle glaucoma intraocular pressure[J]. Chin Med Herald, 2014, 11(18):70-73.
[10] 宋海珊. 拉坦前列素对闭角型青光眼眼压和角膜中央厚度及内皮细胞密度的影响[J]. 国际眼科杂志,2010, 10(12):2385-2386. SONG Haishan. Effect of latanoprost on intraocular pressure, central corneal thickness and endothelial cell density of angle-closure glaucoma[J]. Inter J Ophthalmol, 2010, 10(12):2385-2386.
[11] Lee A J, McCluskey P. Clinical utility and differential effects of prostaglandin analogs in the management of raised intraocular pressure and ocular hypertension[J]. Clin Ophthalmol, 2010, 4:741-764.
[12] Panos G D, Konstantinidis A, Mendrinos E, et al. Effect of tafluprost 0.0015% on central corneal thickness in patients with primary open-angle glaucoma[J]. Curr Eye Res, 2013, 38(9):977-982.
[13] Seibold L K, Ammar D A, Kahook M Y. Acute effects of glaucoma medications and benzalkonium chloride onpre-adipocyte proliferation and adipocyte cytotoxicity in vitro[J]. Curr Eye Res, 2013, 38(1):70-74.
[14] Arita R, Itoh K, Maeda S, et al. Effects of long-term topical anti-glaucoma medications on meibomian glands[J]. Graefes Arch Clin Exp Ophthalmol, 2012, 250(8):1181-1185.
[15] Arita R, Itoh K, Maeda S, et al. Comparison of the long-term effects of various topical antiglaucoma medications on meibomian glands[J]. Cornea, 2012, 31(11):1229-1234.
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