JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (3): 89-92.doi: 10.6040/j.issn.1673-3770.0.2015.530

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Influence of long-term use of prostaglandin drugs on meibomian gland function and corneal structure in patients with primary open angle glaucoma.

LI Dongmei   

  1. Department of Ophthalmology, Mianyang Wanjiang Ophthalmologic Hospital, Mianyang 621000, Sichuan, China
  • Received:2015-12-15 Online:2016-06-16 Published:2016-06-16

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Abstract: Objective To investigate the influence of prostaglandins(PGs)long-term use on meibomian gland function and corneal structure in patients with primary open angle glaucoma(POAG). Methods A total of 31 POAG patients(62 eyes)were include in this study, in which 15 cases without administration of prostaglandin drug were set as the control group; and 16 cases with long-term use of prostaglandin drugs were set as the observation group. Meibomian gland function, shape and cell density of corneal cells, status of subbasal nerve fiber bundles were compared between two groups. Results The density of basal cells, stromal cells and degree of neural distortion were significantly higher in observation group than those in the control group, and density of conjunctival goblet cell, number of branches to cornea subcutaneous nerve were significantly lower in observation group than those than the control group, with significant differences(P<0.05); there was no significnat difference in density of inflammatory cells, Langerhans cells and endothelial cell. neuronal density, and nerve luminosity variations between two groups(P>0.05). the incidence of MGD was 46.7% in the control group and was 71.9% in the observation group(P<0.05). Conclusion Long-term use of PGs may lead a meibomian gland dysfunction and damage to structure of the cornea in patients with glaucoma, including increased risk of MGD, changes in density of subcorneal cells and function of subbasal nerve fiber bundles.

Key words: Meibomian gland, Prostaglandins, Glaucoma, Corneal

CLC Number: 

  • R775
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