JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (2): 99-102.doi: 10.6040/j.issn.1673-3770.0.2017.354

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Analysis of immunoglobulin G4-related ophthalmic disease associated with secondary glaucoma

XIE Hongbin, YANG Meina, CHEN Qingshan, LIU Xuyang, FAN Ning   

  1. Shenzhen Eye Hospital, Affiliated Shenzhen Eye Hospital of Jinan University, Joint College of Optometry of Shenzhen University, Shenzhen 518020, Guangdong, China
  • Received:2017-08-16 Online:2018-03-20 Published:2018-03-20

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Abstract: Objective Immunoglobulin(Ig)G4-related disease has recently been recognized as a relatively rare systemic lesion with abnormal lymphocytes. IgG4-related disease can involve one or multiple organs, and is called IgG4-related ophthalmic disease(IgG4-ROD)when ocular tissue is involved. To analysis of IgG4-ROD associated with secondary glaucoma and to discuss its treatment method. Methods We analyzed clinical manifestations, biopsy, imaging examinations, the response to hormone therapy, and long-term observation. Results The serum IgG4 level is considered the most important serologic characteristic of the disease and has high diagnostic value but lacks specificity. Most patients respond to long-term glucocorticoid therapy, typically with symptomatic improvement, reductions in the size of masses or organ enlargement, improvement in organ function, and often a decrease in serum IgG4 levels. Conclusion Secondary glaucoma is one of the complications associated with IgG4-ROD, but there is still no consensus regarding the choice of surgical procedure, and the long-term postoperative outcome is unknown. It is important to recognize and address the complications of IgG4-ROD and the side effects associated with use of corticosteroids.

Key words: IgG4-related ophthalmic disease, Corticosteroid, Secondary glaucoma

CLC Number: 

  • R775.3
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