Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 13-19.doi: 10.6040/j.issn.1673-3770.1.2018.041

• Invited Review • Previous Articles     Next Articles

Overall diagnosis and treatment strategy for allergic diseases related to hay fever

Kai GUAN1,2,*(),Lianglu WANG1,2   

  1. 1. Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    2. Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing 100730, China
  • Received:2018-11-19 Online:2019-01-20 Published:2019-01-28
  • Contact: Kai GUAN E-mail:dr_guankai@126.com
  • Supported by:
    北京自然科学基金面上项目(7172179);北京协和医学院青年教师培养项目(2015zlgc0726)

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Abstract:

Pollinosis refers to a series of clinical symptoms, such as allergic conjunctivitis, rhinitis, and asthma, that are mediated by specific immunoglobulin E (sIgE) after inhalation of allergic pollens by atopic individuals. The clinical symptoms of pollinosis depend on the season, region, and climate. Common pollens causing pollinosis come from trees, grass, and weeds. In northern China, the quality of life for patients with pollinosis is significantly worse than that for the patients with dust mite allergy. The weed pollen is more likely to induce asthma than the tree pollen. The diagnostic steps for pollinosis include anamnesis, allergen-specific diagnostic tests (skin test and serum sIgE test), and result assessment. Clinical management includes allergen avoidance, allergen-specific immunotherapy, and anti-inflammatory medicines (such as glucocorticoids, H1 antihistamines, and leukotriene receptor antagonists). Clinical data showed that the pollen extracts from the PUMCH Allergen Products Manufacturing and Research Center are particularly useful in the diagnosis of pollinosis. They have good efficacy and safety, and can prevent allergic rhinitis from developing into asthma and inhibit the emergence of reactions to new allergens effectively. Treatment efficacy can be maintained even after stopping active administration.

Key words: Pollinosis, Allergen specific diagnosis, Immunotherapy

CLC Number: 

  • R392.8
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