Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 64-68.doi: 10.6040/j.issn.1673-3770.0.2018.454

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Therapeutic effect of Zao-Jiao-Ci(the spine of Gleditsia sinensis Lam.)granule solution on radiation sinusitis after radiotherapy for nasopharyngeal carcinoma by sinus negative pressure replacement

GUO Sai1, PENG Guiyuan2, XIANG Feng1, HUNAG Xiaoan1, LIN Shanshan1, QIAN Paizi1, LI Linman1, HUANG Guilan1   

  1. Otorhinolaryngology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, Guangdong, China
  • Published:2019-03-28

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Abstract: Objective To investigate the effect of saponin granule solution in the treatment of nasopharyngeal carcinoma after radiotherapy with radioactive sinusitis. Method Thirty patients with radioactive sinusitis after radiotherapy for nasopharyngeal carcinoma were randomly divided into the saponin group and the saline group. The saponin group received 20 mL of saponin granule solution for sinus negative pressure replacement treatment, 5 times a week; the saline group received 20 mL of normal saline for sinus negative pressure replacement, 5 times a week; the course of treatment was 3 week. Visual analogue scores(VAS)of nasal symptoms(including nasal obstruction, nasal secretion, anterior nasal secretion, headache/facial pain, loss of smell)and endoscopic scores(Kennedy scores)were performed of both groups before and after treatment. The efficacy and adverse reactions of the two groups were compared. Result There were no significant differences in the pre-treatment VAS and Kennedy scores between the two groups(P is 0.500 6, 0.725 7 respectively). However, after 3 weeks of treatment, the improvement of VAS of nasal secretion, nasal obstruction and loss of smellin the Zao-Jiao-Ci group, and the improvement of nasal endoscopic scores of nasopharyngeal secretion, middle nasal secretions and mucosal edema were significantly higher than those in the saline group, the differences were statistically significant(P is 0.003 3, 0.046 4, 0.018 8, <0.000 1, <0.000 1, <0.000 1). The total effective rate of the saponin group and the saline group were 100% and 26.67%, respectively. The difference between the two groups was statistically significant(χ2=22, P<0.000 1). There was no significant difference in the incidence of adverse reactions between the two groups(χ2=0.000 0, P=1.000). Conclusion The Zao-Jiao-Ci granule solution is effective in the treatment of nasopharyngeal carcinoma after radiotherapy with radiation sinusitis by sinus negative pressure replacement, which can significantly improve the clinical symptoms of patients and is safer.

Key words: the spine of Gleditsia sinensis Lam. granule, Sinus negative pressure replacement, Radioactive sinusitis

CLC Number: 

  • R276.1
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