Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 64-68.doi: 10.6040/j.issn.1673-3770.0.2018.454

Previous Articles    

Therapeutic effect of Zao-Jiao-Ci(the spine of Gleditsia sinensis Lam.)granule solution on radiation sinusitis after radiotherapy for nasopharyngeal carcinoma by sinus negative pressure replacement

GUO Sai1, PENG Guiyuan2, XIANG Feng1, HUNAG Xiaoan1, LIN Shanshan1, QIAN Paizi1, LI Linman1, HUANG Guilan1   

  1. Otorhinolaryngology Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, Guangdong, China
  • Published:2019-03-28

PDF (PC)

523

Abstract: Objective To investigate the effect of saponin granule solution in the treatment of nasopharyngeal carcinoma after radiotherapy with radioactive sinusitis. Method Thirty patients with radioactive sinusitis after radiotherapy for nasopharyngeal carcinoma were randomly divided into the saponin group and the saline group. The saponin group received 20 mL of saponin granule solution for sinus negative pressure replacement treatment, 5 times a week; the saline group received 20 mL of normal saline for sinus negative pressure replacement, 5 times a week; the course of treatment was 3 week. Visual analogue scores(VAS)of nasal symptoms(including nasal obstruction, nasal secretion, anterior nasal secretion, headache/facial pain, loss of smell)and endoscopic scores(Kennedy scores)were performed of both groups before and after treatment. The efficacy and adverse reactions of the two groups were compared. Result There were no significant differences in the pre-treatment VAS and Kennedy scores between the two groups(P is 0.500 6, 0.725 7 respectively). However, after 3 weeks of treatment, the improvement of VAS of nasal secretion, nasal obstruction and loss of smellin the Zao-Jiao-Ci group, and the improvement of nasal endoscopic scores of nasopharyngeal secretion, middle nasal secretions and mucosal edema were significantly higher than those in the saline group, the differences were statistically significant(P is 0.003 3, 0.046 4, 0.018 8, <0.000 1, <0.000 1, <0.000 1). The total effective rate of the saponin group and the saline group were 100% and 26.67%, respectively. The difference between the two groups was statistically significant(χ2=22, P<0.000 1). There was no significant difference in the incidence of adverse reactions between the two groups(χ2=0.000 0, P=1.000). Conclusion The Zao-Jiao-Ci granule solution is effective in the treatment of nasopharyngeal carcinoma after radiotherapy with radiation sinusitis by sinus negative pressure replacement, which can significantly improve the clinical symptoms of patients and is safer.

Key words: the spine of Gleditsia sinensis Lam. granule, Sinus negative pressure replacement, Radioactive sinusitis

CLC Number: 

  • R276.1
[1] Feng S, Fan Y, Liang Z, et al. Effect of intranasal steroids on rhinosinusitis after radiotherapy for nasopharyngeal carcinoma: clinical study[J]. J Laryngol Otol, 2016, 130(3):265-271.doi:10.1017/s0022215115003448.
[2] Ayoub N, Walgama E, Thamboo A, et al. Efficacy of endoscopic sinus surgery for chronic rhinosinusitis following primary radiotherapy and concurrent chemotherapy for nasopharyngeal carcinoma[J]. Int Forum Allergy Rhinol, 2017, 7(11): 1045-1051. doi: 10.1002/alr.22002.
[3] 黎婉红,蔡邦,莫鉴文,等.鼻咽癌放疗后鼻窦炎临床特征及其影响因素的Logistic分析[J]. 广州医学, 2018, 49(5):24-28.doi:10.3969/j.issn.1000-8535.2018.05.006. LI Wanghong, CAI Bang, MO Jianwen, et al. Logistic analysis of clinical features and influencing factors of sinusitis after radiotherapy for nasopharyngeal carcinoma [J].Guangzhou Medical, 2018, 49(5): 24-28.doi: 10.3969/j.issn.1000-8535.2018.05.006.
[4] 陈怀宏, 吴德华, 梁勇,等. 鼻咽癌放射治疗后继发慢性鼻-鼻窦炎的临床特征分析[J]. 中华耳鼻咽喉头颈外科杂志, 2009, 44(4):307-310.doi: 10.3760/cma.j.issn.1673-0860.2009.04.011. CHEN Huaihong, WU Dehua, LIANG Yong, et al. Clinical characteristics of chronic rhinosinusitis after radiotherapy for nasopharyngeal carcinoma[J]. Chin J Otorhinolaryngol Head Neck Surg, 2009, 44(4): 307-310.doi: 10.3760/cma.j.issn.1673-0860.2009.04.011.
[5] 中华医学会耳鼻咽喉科学分会,中华耳鼻咽喉科杂志编辑委员会.慢性鼻窦炎鼻息肉临床分型分期及内窥镜鼻窦手术疗效评定标准(1997年,海口)[J]. 中华耳鼻咽喉头颈外科杂志, 1998,33(3):134. Chinese Medical Association, Editorial Board of Chinese Journal of Otorhinolaryngology. Clinical classification of chronic sinusitis and nasal polyps and evaluation criteria for endoscopic sinus surgery(Haikou, 1997)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 1998,33(3):134.
[6] 马士崟, 江浩, 王飞,等. 144例鼻咽癌常规放疗后鼻窦炎发生的因素分析[J]. 中华放射医学与防护杂志, 2010, 30(4): 439-441.doi: 10.3760/cma.j.issn.0254-5098.2010.04.018. MA Shizhen, JIANG Hao, WANG Fei, et al. Analysis of the factors influencing the occurrence of sinusitis after conventional radiotherapy for 144 cases of nasopharyngeal carcinoma[J]. Chinese Journal of Radiological Medicine and Protection, 2010, 30(4): 439-441.doi:10.3760/cma.j.issn.0254-5098.2010.04.018.
[7] Qiu W Z, Ke L R, Xia W X,et al.A retrospective study of 606 cases of nasopharyngeal carcinoma with or without oropharyngeal candidiasis during radiotherapy[J]. Plos One, 2017, 12(8): e0182963.doi: 10.1371/journal.pone.0182963.
[8] 黄振云, 邹华, 黄晓明,等. 鼻咽癌患者放疗前及放疗期间黏液纤毛输送功能及其形态学观察[J]. 中华耳鼻咽喉头颈外科杂志, 2005, 40(12):940-942.doi: 10.3760/j.issn:1673-0860.2005.12.017. HUANG Zhenyun, ZOU Hua, HUANG Xiaoming, et al. Mucin cilia transport function and morphological observation in patients with nasopharyngeal carcinoma before and during radiotherapy[J]. Chin J Otorhinolaryngol Head Neck Surg, 2005, 40(12): 940-942.doi: 10.3760/j.issn:1673-0860.2005.12.017.
[9] 黄波, 韦海明, 兰桂萍,等. 鼻咽癌放射治疗后鼻黏膜形态学变化与鼻窦炎发生的关系[J]. 广西医学, 2008, 30(9):1301-1303.doi:10.3969/j.issn.0253-4304.2008.09.004. HUANG Bo, WEI Hai-ming, LAN Gui-ping, et al. Relationship between morphological changes of nasal mucosa and occurrence of sinusitis after radiotherapy for nasopharyngeal carcinoma[J]. Guangxi Med J, 2008, 30(9): 1301-1303.doi:10.3969/j.issn.0253-4304.2008.09.004.
[10] 刘建建, 时鹏, 黄涛,等. 皂角刺提取物体外抑菌杀菌作用研究[J]. 医药导报, 2013, 32(3):300-302.doi: 10.3870/yydb.2013.03.008. LIU Jianjian, SHI Peng, HUANG Tao, et al. Study on antibacterial and bactericidal action of saponin extracts[J]. J Med Herald, 2013, 32(3): 300-302.doi: 10.3870/yydb.2013.03.008.
[11] 倪付花, 桑青, 陈敏, 等. 皂荚皂苷的提取及其抑菌作用的研究[J]. 时珍国医国药, 2012, 23(2):351-352.doi:10.3969/j.issn.1008-0805.2012.02.043.NI Fuhua, SANG Qing, CHEN Min, et al. Extraction and Antibacterial Activity of Gleditsia Saponins[J]. Shizhen Guo Yi Guo Yao, 2012, 23(2):351-352.doi: 10.3969/j.issn.1008-0805.2012.02.043.
[12] 唐隽,施思斯, 萧建新,等. 鼻咽癌放疗后继发慢性鼻窦炎的临床特征[J]. 山东大学耳鼻喉眼学报, 2015, 29(2): 52-54.doi: 10.6040/j.issn.1673-3770.0.2014.115. TANG Jun, SHI Si Si, XIAO Jianxin, et al.Clinical features of chronic sinusitis after radiotherapy for nasopharyngeal carcinoma[J]. Journal of Otolaryngology, Shandong University, 2015, 29(2): 52-54.doi: 10.6040/j.issn.1673-3770.0.2014.115.
[13] Kai K L, Zhou X, Wong H L, et al. In vivo, and in vitro, anti-inflammatory effects of Zao-Jiao-Ci(the spine of Gleditsia sinensis, Lam.)aqueous extract and its mechanisms of action[J]. J Ethnopharmacol, 2016, 192:192-200.
[14] 王莹莹, 刘伟杰, 杜钢军. 皂角刺抗肿瘤的初步研究[J]. 河南大学学报(医学版), 2014(2): 88-90. WANG Yingying, LIU Weijie, DU Gangjun. Preliminary study on anti-tumor effect of saponin[J]. J Henan Univ(Health Sciences), 2014(2): 88-90.doi: 10.1016/j.jep.2016.07.020.
[15] 曹冉冉,高嘉屿,刘华清,等.皂角刺中二氢黄酮醇类化合物及其细胞毒活性研究[J].中草药,2016, 47(5):707-711.doi: 10.7501/j.issn.0253-2670.2016.05.002. CAO Ranran, GAO Jiayu, LIU Huaqing,et al.Study on dihydroflavonols and their cytotoxic activities in saponins[J]. Chinese Traditional and Herbal Drugs, 2016, 47(5): 707-711.doi: 10.7501/j.issn.0253-2670.2016.05.002.
[16] 郭丽青, 雷晓兰, 柳冰. 鼻腔正负压置换治疗放射性鼻窦炎的疗效[J]. 实用临床医学, 2017, 18(6): 79-80.doi: 10.13764/j.cnki.lcsy.2017.06.032. GUO Liqing, LEI Xiaolan, LIU Bing. Therapeutic effect of nasal positive and negative pressure replacement for radiation sinusitis[J]. J Clin Med, 2017, 18(6): 79-80.doi: 10.13764/j.cnki.lcsy.2017.06.032.
[17] 姜义道, 毛承刚. 负压置换加鼻腔冲洗治疗放射性鼻窦炎疗效观察[J]. 中国耳鼻咽喉颅底外科杂志, 2011, 17(6): 454-455. JIANG Yidao, MAO Chenggang. Clinical observation of negative pressure replacement plus nasal irrigation for radiation sinusitis[J]. Chin J Otorhinolaryngol Skull Base Surg, 2011, 17(6): 454-455.
No related articles found!
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd