To explore the clinical efficacy in patients who underwent endoscopic nasopharyngectomy for primary advanced nasopharyngeal carcinoma (NPC).Methods
Clinical data of 35 patients with NPC admitted to the Department of Otorhinolaryngology Head and Neck Surgery and Nasal Skull Base Surgery of the Affiliated Hospital of Qingdao University from January 2010 to June 2018 were retrospectively reviewed. Twenty-one patients were male, and 14 were female. The median age was 52 years (range, 17-75 years). There were five cases of nasal obstruction, 13 cases of snot with blood, 4 cases of hearing loss and stuffy ear, 5 cases of neck mass, 3 cases of pharyngeal discomfort, and 5 cases of headache and diplopia. The TNM stages were: 5 cases were at stageⅠ, 12 cases were at stage Ⅱ, 12 cases were at stage Ⅲ, and 6 cases were at stage Ⅳ. NX 2 cases, N0 16 cases N1 9 cases, N2 7cases, N3 1 case. No patient was found to have distant metastasis. All patients underwent endoscopic resection of the lesions. Postoperatively, all patients were treated with radiotherapy or chemoradiotherapy. Using SPSS 22.0 software, Kaplan-Meier analysis and Log-rank test were done for the assessment of survival rate.Results
The pathological types of the 35 patients were as follows: 22 patients had undifferentiated type of non-keratinized carcinoma, 5 patients had non-keratinized differentiated carcinoma, and 8 patients had squamous-cell carcinoma. The follow-up ranged from 3 to 95 months, with relapse observed in 3 cases (10.0%), survival in 31 cases (82.5%), and death in 4 cases (17.5%). The overall 1 year survival rate (SR), 3 year SR, 5 year SR were 95.23%, 95.23%, and 87.91%, respectively.Conclusion
Patients who undergo endoscopic nasopharyngectomy for NPC have better long-term prognosis.