Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 136-138.doi: 10.6040/j.issn.1673-3770.0.2018.317

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Research progress on the regulation of HIF-1α expression in thyroid carcinoma

SONG Xiaoyu1,2, SONG Xicheng1,2   

  1. Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China
  • Published:2019-03-28

Abstract: Intratumoral hypoxia is an important factor leading to poor tumor prognosis. Hypoxia inducible factor-1α(HIF-1α)is the major regulatory factor promoting tumor invasion and metastasis, and its expression in tumor cells is related to several factors. The regulatory mechanism of HIF-1α in thyroid carcinoma may be related to BRAFV600E regulation and regulation of CXCR4, VEGF, PTEN, and CD44V6 expression.

Key words: Thyroid neoplasms, Tumor hypoxia microenvironment, Hypoxia inducible factor-1α

CLC Number: 

  • R736.1
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