Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 56-59.doi: 10.6040/j.issn.1673-3770.0.2018.230

Previous Articles     Next Articles

Expression of immunological markers in middle ear effusion in children with secretory otitis media

NI Jing1, LEI Fei2, BAI Dan1, ZHOU Yun1, MA Jianmei1, HUANG Wei1, WANG Chunyang1   

  1. Department of Stomatology, the Second Affiliated Hospital of Xi′an Medical College, Xi′an 710038, Shaanxi, China
  • Online:2019-07-20 Published:2019-07-22

PDF (PC)

264

Abstract: Objective To evaluate the expression of immunological markers in middle ear effusion in children with secretory otitis media. Methods The research group included 30 patients with secretory otitis media, who were treated in our hospital from December 2016 to December 2017, while 30 healthy children were selected as the control group. The percentages of CD4+T and CD8+T cells and the CD4+/CD8+ ratio in the peripheral blood of the two groups were compared. The levels of IL-2, IL-4, and IL-6 in the middle ear effusion and plasma between the two groups were compared. The correlation of CD4+T and CD8+T cell values and IL-2, IL-4, and IL-6 in middle ear effusion was analyzed. Results The percentages of CD4+T and CD8+T cells in peripheral blood of the study group were significantly higher than that in the control group, and the CD4+/CD8+ ratio was significantly lower than that in the control group with a statistically significant difference(P<0.01). The levels of IL-2, IL-4, and IL-6 in the middle ear effusion of the group were significantly higher than that in the plasma, and the difference was statistically significant(P<0.01). The levels of IL-2, IL-4, and IL-6 in the study group were significantly higher than those in the control group, and the difference was statistically significant(P<0.01). Pearson linear correlation analysis showed that the levels of IL-2, IL-4, and IL-6 in the middle ear effusion of the group had a significantly positive correlation with CD4+T and CD8+T cell values in peripheral blood(P<0.01). Conclusion Secretory otitis media is closely related to the strong immune response and the phenomenon of significant rise in the CD4+T and CD8+T cell subgroup. Additionally, IL-2, IL-4, IL-6 showed a certain clinical significance in diagnosing and managing secretory otitis media in children.

Key words: Children, Secretory otitis media, Middle ear effusion, Immune, Infection

CLC Number: 

  • R764.2
[1] Feng CY, Zhang QC, Zhou GQ, et al. Roles of T follicular helper cells in the pathogenesis of adenoidal hypertrophy combined with secretory otitis media[J]. Medicine(Baltimore), 2018, 97(13): e0211. doi:10.1097/MD.0000000000010211.
[2] Lameiras AR, Silva D, O Neill A, et al. Quality of life of children with otitis media and impact of insertion of transtympanic ventilation tubes in a portuguese population[J]. Acta Med Port, 2018, 31(1): 30-37. doi:10.20344/amp.9457.
[3] Ungkanont K, Boonyabut P, Komoltri C, et al. Surveillance of otitis media with effusion in thai children with cleft palate: cumulative incidence and outcome of the management[J]. Cleft Palate Craniofac J, 2018, 55(4): 590-595. doi:10.1177/1055665617730361.
[4] Akcan FA, Dündar Y, Akcan HB, et al. Clinical role of vitamin D in prognosis of otitis media with effusion[J]. Int J Pediatr Otorhinolaryngol, 2018, 105: 1-5. doi:10.1016/j.ijporl.2017.11.030.
[5] La Mantia I, Andaloro C. Effects of salso-bromo-iodine thermal water in children suffering from otitis media with effusion: a randomized controlled pilot study[J]. Clin Ter, 2018, 169(1): e10-e13. doi:10.7417/T.2018.2047.
[6] Blioskas S, Karkos P, Psillas G, et al. Factors affecting the outcome of adenoidectomy in children treated for chronic otitis media with effusion[J]. Auris Nasus Larynx, 2018, 45(5): 952-958. doi:10.1016/j.anl.2018.01.003.
[7] Simon F, Haggard M, Rosenfeld RM, et al. International consensus(ICON)on management of otitis media with effusion in children[J]. Eur Ann Otorhinolaryngol Head Neck Dis, 2018, 135(1S): S33-S39. doi:10.1016/j.anorl.2017.11.009.
[8] Akazawa K, Doi H, Ohta S, et al. Relationship between Eustachian tube dysfunction and otitis media with effusion in radiotherapy patients[J]. J Laryngol Otol, 2018, 132(2): 111-116. doi:10.1017/S0022215118000014.
[9] Zernotti ME, Pawankar R, Ansotegui I, et al. Otitis media with effusion and atopy: is there a causal relationship?[J]. World Allergy Organ J, 2017, 10(1): 37. doi:10.1186/s40413-017-0168-x.
[10] Gan RWC, Daniel M, Ridley M, et al. Quality of questionnaires for the assessment of otitis media with effusion in children[J]. Clin Otolaryngol, 2018, 43(2): 572-583. doi:10.1111/coa.13026.
[11] Zhang JB, Zhong Z, Xiao SF, et al. Tubomanometry value as an associated factor for medication outcomes in adult acute otitis media with effusion[J]. Eur Arch Otorhinolaryngol, 2018, 275(1): 53-57. doi:10.1007/s00405-017-4772-8.
[12] Bakshi SS. Neutrophil-lymphocyte and platelet-lymphocyte ratio for the effusion viscosity in otitis media[J]. J Craniofac Surg, 2018, 29(1): e98. doi:10.1097/SCS.0000000000004021.
[13] Chiappini E, Bortone B, Doria M, et al. What not to do in acute otitis media: the top five recommendations proposed by the Italian Society of Preventive and Social Pediatrics[J]. Expert Rev Anti Infect Ther, 2017, 15(10): 897-902. doi:10.1080/14787210.2017.1380518.
[14] Rahmati MB, Safdarian F, Shiroui B, et al. Montelukast versus inhaled mometasone for treatment of otitis media with effusion in children: A randomized controlled trial[J]. Electron Physician, 2017, 9(7): 4890-4894. doi:10.19082/4890.
[1] XU Juan, CUI Biao, HUANG Jianping, CHEN Yibiao, SHI Jianfei, WANG Yanwen, LIU Zanhua, ZHANG Jianwei. Clinical application of FEES-based swallowing function assessment in elderly patients with pulmonary infections [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 74-79.
[2] ZHU Xiqian, WANG Jia, SUN Zuxian, FENG Jianxiu, ZHANG Mengjia, ZHAO Ying, WANG Hong, JIANG Minmin. Refractive status of school-aged children aged 6-9 years in Yangpu District, Shanghai, 2022-2024: a cohort study [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 102-109.
[3] XIN Min, WANG Shaoming. Neuroimmune mechanisms and therapeutic strategies of inflammatory and infectious olfactory dysfunction [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 111-124.
[4] LI Kang, LI Xuanyi, LIU Wen. Diagnosis and treatment of chronic suppurative otitis media combined with fungal infection of the external auditory canal [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 23-30.
[5] SONG Yanling, SI Yuanyuan, CUI Yan. Minimal quantity vitrectomy for laser-pointer induced full-thickness macular hole in a child: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 144-147.
[6] LIU Nanxian, YANG Zeyin, HAN Lin, ZHANG Aiying, ZHAO Yuliang, XUE Jing, SUN Yijun, SHAO Yongliang. Significance of video-EEG in the diagnosis of recurrent vertigo in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 20-25.
[7] HUANG Huan, HUA Hongli, DENG Yuqin, JIANG Chengyang, WANG Yuwei, YANG Xinghai. Correlation of allergic rhinitis, tonsil adenoid hypertrophy, and sinusitis in children and analysis of its clinical guiding value [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 34-41.
[8] WANG Hua, ZHANG Fengzhen, LONG Ting, ZHAO Jing, LI Hongbin, WANG Shengcai, WANG Guixiang. Analysis of the reasons and prognostic outcomes for tracheostomy in pediatric patients following posterior fossa tumor resection [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 168-173.
[9] YUE Bingyan, ZOU Jian, LEI Lei, WEN Qiao, QIAN Yingxue. Tonsillar microbiota of children, immune regulation and diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 193-200.
[10] HUANG Aiping, WANG Juan, WANG Li, GENG Jiangqiao, WANG Yafang, WEN Xin. Tonsil Burkitt lymphoma involving pulmonary and maxilla in children: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 148-152.
[11] LIU Chang, YANG Jingpu, GAO Yu, WANG Wenjia. Analysis of allergen detection results in children with allergic rhinitis in the Changchun area [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 51-58.
[12] FU Shengyao, CHEN Min, PANG Wenhui, LI Na. Endoscopic-assisted individualized surgical approach for the treatment of nasal dermoid and sinus cysts in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 65-71.
[13] CHEN Danping, HE Zijian, YU Youjun, ZHOU Xiaowei. Analysis of the efficacy and prognostic factors of hospitalized cases of children with sudden sensorineural hearing loss for ten years [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 16-22.
[14] YANG Na, LIU Yin, GUO Bao, JI Yaofeng, CHENG Chen, ZHANG Chen, DONG Lina. High frequency ultrasound in closed reduction of nasal fracture in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 41-45.
[15] WANG Dengmao, WEN Xin, GENG Jiangqiao, ZHANG Guangyuan, LIU Xiaofeng. Tubal hair polyp complicated with nasopharyngeal hamartoma in children: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 105-109.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd