Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 7-10.doi: 10.6040/j.issn.1673-3770.0.2020.060

Previous Articles     Next Articles

Effect of repetitive transcranial magnetic stimulation on chronic vestibular syndrome

LI Jiawei, LIU Xiaoyang, YANG Xingyu, SUN Xiaoming, LI Xidan   

  1. Department of Electrophysiology Science, Dalian Third People's Hospital, Dalian 116000, Liaoning, China
  • Published:2021-02-01

Abstract: Objective This study aimed to investigate the effect of repetitive transcranial magnetic stimulation(rTMS)on chronic vestibular syndrome(CVS). Methods Sixty patients with chronic vestibular syndrome(CVS)were randomly divided into a control group and a treatment group, each with 30 patients. Patients in both groups performed eye-tracking exercises in the vertical and horizontal directions. The treatment group was treated with rTMS for 4 weeks. The dizziness evaluation scale(DHI)score and unilateral/bilateral semicircular canal response(UW)values of the two groups before and after treatment were compared and analyzed. Results There was no significant difference in DHI score between the treatment group and the control group before treatment(P=0.872)while there was no significant difference in UW value between hot and cold test(P=0.079). However, after treatment, the difference of DHI score was statistically significant between the two groups(P<0.01)and the UW value of cold and hot test decreased, and the difference was statistically significant(P=0.02), There were significant differences in DHI score and UW value between the two groups before and after treatment(P<0.01), The difference in DHI score before and after treatment in the treatment group was 39.40 points, while the difference in DHI score before and after treatment in the control group was 25.67 points, the difference in UW score before and after treatment in the treatment group was 16.03, and the difference in UW score before and after treatment in the control group was 12.03. Conclusion rTMS is effective in the treatment of CVS and is good for promoting the establishment of vestibular compensation.

Key words: Repetitive transcranial magnetic stimulation, Chronic vestibular syndrome, Vestibular rehabilitation, Caloric test, Dizziness evaluation scale

CLC Number: 

  • R512
[1] Alexandre R. Bisdorff, Jeffrey P.Staab, David E. Newman-Toker. Overview of the international classification of vestibular disorders[J]. Neurol Clin, 2015, 33(3): 541-550. doi: 10.1016/j.ncl.2015.04.010.
[2] Strupp M, Mandalà M, López-Escámez JA. Peripheral vestibular disorders[J]. Curr Opin Neurol, 2019, 32(1): 165-173. doi:10.1097/wco.0000000000000649.
[3] Strupp M, Brandt T. Peripheral vestibular disorders[J]. Curr Opin Neurol, 2013, 26(1): 81-89. doi:10.1097/wco.0b013e32835c5fd4.
[4] Guo F, Lou JC, Han XH, et al. Repetitive transcranial magnetic stimulation ameliorates cognitive impairment by enhancing neurogenesis and suppressing apoptosis in the Hippocampus in rats with ischemic stroke[J]. Front Physiol, 2017, 8: 559. doi:10.3389/fphys.2017.00559.
[5] Luo J, Zheng HQ, Zhang LY, et al. High-frequency repetitive transcranial magnetic stimulation(rTMS)improves functional recovery by enhancing neurogenesis and activating BDNF/TrkB signaling in ischemic rats[J]. Int J Mol Sci, 2017, 18(2): 455. doi:10.3390/ijms18020455.
[6] 殷稚飞, 程清, 秦义婷, 等. 小脑经颅磁刺激调控脑高级功能的研究进展[J]. 中华物理医学与康复杂志, 2018, 40(10): 791-794. doi:10.3760/cma.j.issn.0254-1424.2018.10.019.
[7] 鞠奕, 田军茹. 慢性前庭综合征的临床诊断及治疗[J]. 中华内科杂志, 2016, 55(10): 753-754. doi:10.3760/cma.j.issn.0578-1426.2016.10.005.
[8] World Health Organization. The international classification of diseases, ICD-11 beta draft[S/OL]. [2015-01-30].
[9] 中国医药教育协会眩晕专业委员会, 中国康复医学会眩晕与康复专业委员会, 中西医结合学会眩晕专业委员会, 等. 前庭功能检查专家共识(一)(2019)[J]. 中华耳科学杂志, 2019, 17(1): 117-123. doi:10.3969/j.issn.1672-2922.2019.01.020.
[10] 于立身. 前庭功能检查技术[M]. 西安: 第四军医大学出版社, 2013.
[11] Jacobson GP, Newman CW. The development of the dizziness handicap inventory[J]. Arch Otolaryngol-Head Neck Surg, 1990, 116(4): 424-427. doi:10.1001/archotol.1990.01870040046011.
[12] Han BI, Song HS, Kim JS. Vestibular rehabilitation therapy: review of indications, mechanisms, and key exercises[J]. J Clin Neurol, 2011, 7(4): 184. doi:10.3988/jcn.2011.7.4.184.
[13] Hall CD, Herdman SJ, Whitney SL, et al. Vestibular rehabilitation for peripheral vestibular hypofunction: an evidence-based clinical practice guideline: from the American physical therapy association neurology section[J]. J Neurol Phys Ther, 2016, 40(2): 124-155. doi:10.1097/npt.0000000000000120.
[14] Yuri Agrawal, John P Carey, Charles C Della Santina, et a1. Disorders of balance and vestibular function in US adults: data from the national health and nutrition examination survey, 2001-2004[J]. Arch Intern Med, 2009, 169(10): 938-944. doi: 10.1001/archinternmed.2009.66.
[15] Horak FB, Jones-Rycewicz C, Black FO, et al. Effects of vestibular rehabilitation on dizziness and imbalance[J]. Otolaryngol Head Neck Surg, 1992, 106(2): 175-180. doi:10.1177/019459989210600220.
[16] Hall CD, Herdman SJ, Whitney SL, et a1. Vestibular rehabilitation for peripheral vestibular hypofunction:an evidence-based clinical practice guideline[J]. J Neurol Phys Ther, 2016, 40(2): 124-155. doi: 10.1097/NPT.0000000000000120.
[17] 刘波. 前庭功能低下患者康复治疗流程管理的循证医学证据进展[J]. 中国耳鼻咽喉头颈外科, 2019, 26(5): 272-276. doi:10.16066/j.1672-7002.2019.05.010.
[18] 王冰, 李玮, 李六一, 等. 低频经颅磁刺激治疗阵发性位置性眩晕患者成功手法复位后残余头晕的疗效观察[J]. 中华物理医学与康复杂志, 2017, 39(4): 286-289. doi: 10.3760/cma.j.issn.0254-1424.2017.04.011.
[19] Colnaghi S, Honeine JL, Sozzi S, et al. Body sway increases after functional inactivation of the cerebellar vermis by cTBS[J]. Cerebellum, 2017, 16(1): 1-14. Doi: 10.1007/s12311-015-0758-5.
[20] Mancic B, Stevanovic I, Ilic TV, et al. Transcranial Theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex[J]. Neurochem Int, 2016, 100: 120-127. doi:10.1016/j.neuint.2016.09.009.
[21] 林鹏, 董红, 陈太生, 等. 冷热试验优势偏向对前庭动态代偿评估价值的探讨[J]. 中华耳鼻咽喉头颈外科杂志, 2009, 44(8): 631-635. doi:10.3760/cma.j.issn.1673-0860.2009.08.006.
[1] Vertigo is one of the most important symptom of peripheral vestibular diseases which are difficult to differentially diagnose and manage because multiple disciplines are involved. The premise of effective management is accurate diagnosis of vestibular diseases. With the development of vestibular function examination technology and the deepening of vestibular disease research, great progress has been made in the diagnosis and management of vestibular diseases. The establishment and publication of international classification of vestibular diseases, the introduction of diagnostic standards for various vestibular diseases in the world, the formulation of vestibular disease drugs, surgical specifications and the rapid development of vestibular rehabilitation technology make the diagnosis and management of vestibular diseases more and more standardized and accurate.. Diagnosis and management of peripheral vestibular diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 1-6.
[2] To analyze the clinical outcomes of patients with unilateral idiopathic sudden sensorineural hearing loss(SSNHL)and explore the relationship between vestibular function and prognosis in patients with SSNHL. MethodsA retrospective analysis of patients( ears)with SSNHL was performed. A total of vestibular function tests were performed in all patients to assess the influence of vestibular functions on the clinical outcome of SSNHL. ResultsTreatments were less effective in patients with abnormalities in ocular vestibular evoked myogenic potential(oVEMP)or cervical vestibular evoked myogenic potential(cVEMP). Those with normal oVEMP and cVEMP had relatively better hearing recovery. The outcomes of the caloric test or video head impulse test showed no association with the efficacy of treatment or hearing recovery in patients with SSNHL. Treatment was less effective in patients with abnormalities in both oVEMP and cVEMP, who also had worse hearing recovery than those who had an abnormal finding in only one of the two tests. ConclusionsPatients with abnormal oVEMP or cVEMP results had poor clinical outcomes, while those with normal oVEMP and cVEMP demonstrated better hearing recovery with treatment. Thus, oVEMP and cVEMP could be effective indices to predict the prognosis of patients with SSNHL. An abnormal vestibular function is a definite indicator of a wider and more severe pathological change in the inner ear of patients with SSNHL.. Clinical value of vestibular evoked myogenic potential to predict prognosis of unilateral idiopathic sudden sensorineural hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 27-32.
[3] To explore the relationship between dizziness-vertigo and nystagmus intensity, according to the nystagmus accompanied by dizziness and/or vertigo during caloric test. MethodsThe relationship between dizziness and vertigo sensations and nystagmus intensity was analyzed in 399 patients with peripheral vestibular disorders,who underwent routine caloric test. The nystagmus intensity is as an index, accompanied by dizziness and/or vertigo sensations induced during caloric test. ResultsWarm and cold stimulation induced dizziness and vertigo and associated nystagmus overall analysis, the intensity of nystagmus was always greater than that of dizziness when vertigo occurred. The nystagmus thresholds for dizziness and vertigo induced by warm and cold air stimulation in the left ears were 4.2°/s and 5.9°/s for cold, 4.2°/s and 8°/s for warm, in the right ears were 4.6°/s and 6.2°/s for cold, 5.3°/s and 6.5°/s for warm, respectively. Three hundred ninety nine patients were subjected to alternating warm and cold stimulation in both ears for a total of 1596 times, which induced dizziness 513 times(32.14%), of which 312 times only dizziness and 201 times vertigo ten seconds after dizziness. Vertigo was induced 906 times(56.77%), of which 705 occurred directly without transitioning from dizziness to vertigo, and another 201 times vertigo occurred after ten seconds of dizziness; 378(23.68%)times did not induce dizziness and vertigo. ConclusionsVertigo corresponds to a higher nystagmus intensity threshold than dizziness, with patients showing dizziness when the nystagmus is weak and vertigo when it is stronger. Warm and cold air stimulation induced nystagmus intensity from weak to strong, and from dizziness to vertigo sensations induced at the same time, suggesting that the symptoms of dizziness and vertigo are related to the asymmetric between the two vestibular tension.. Study of the relationship of dizziness and vertigo sensations with the nystagmus intensity [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 56-60.
[4] Vestibular rehabilitation training is important for treating vestibular diseases and improving vertigo symptoms. However, the large number of patients, the lack of venues and rehabilitation specialists, and medical expenses have limited its application at all levels in hospitals. With the development of smartphones and the mobile internet, home-based rehabilitation and remote guidance have become possible. Therefore, we developed a remote vestibular rehabilitation training guidance platform to be accessed with smartphones and the mobile internet. The platform design is based on the Browser/Server mode structure; it has IOS and Android versions and supports wireless access smartphone terminals. The platform facilitates a more convenient, smooth, and effective remote guidance for vestibular rehabilitation function exercises, curative effect evaluations, and follow-up; this improves efficiency and compliance as well as reduces the technical barriers, site restrictions, and labor costs of vestibular rehabilitation. This paper introduces the functional design, related technology realization, and the operational effect of the platform.. Development and application of a vestibular rehabilitation training guidance platform [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 78-81.
[5] DING Jian, LIU Yiming. Effect of vestibular rehabilitation on residual dizziness in elderly patients with benign paroxysmal positional vertigo [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 64-68.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] YANG Changliang,HUANG Zhiwu,YAO Hangqi,ZHU Yong,SNU Yi . Study on auditory brainstem response[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 9 -13 .
[2] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 89 -89 .
[3] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 90 -91 .
[4] LIU Da-yu,PAN Xin-liang,LEI Da-peng,ZHANG Li-qiang,LUAN Xin-yong . Surgical treatment for medial wall pyriform sinus cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 8 -11 .
[5] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 188 -188 .
[6] LIU Yan,LIU Xin-yi,WANG Jin-ping,LI Da-jian . Measurement of the posterior tympanum and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 218 -221 .
[7] ZHAO Min,WANG Shou-sen,ZHEN Ze-nian,CHEN Xian-ming,WANG Mao-xin . Sphenoid sinus and trans-sphenoid surgery under nasal endoscopy and microscopy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 244 -245 .
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 252 -252 .
[9] WANG Hong-xia,WANG Peng-cheng . Expression of NSE,S100 and GFAP in retinoblastoma and its clinical significance[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 263 -264 .
[10] HUANG Fang,HUANG Hai-qiong,HUANG Jian-qiang,HE He-fan . Bronchoscopic video supervision system in infant bronchial foreign bodies[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 276 -277 .