Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 1-6.doi: 10.6040/j.issn.1673-3770.0.2020.087

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Analysis of distant metastasis and prognosis of adenoid cystic carcinoma of the external auditory canal

WANG Yingying, ZHOU Han, DONG Weida, XING Guangqian, CHEN Zhibin, ZHANG Qingzhao, ZHANG Liqing   

  1. Department of Otolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nangjing 210029, Jiangsu, China
  • Published:2021-02-01

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Abstract: Objective This study aimed to investigate the risk factors of distant metastasis of adenoid cystic carcinoma of the external auditory canal and its influence on prognosis. Methods We performed a retrospective analysis of the clinical data and follow-up information of 22 patients who underwent radical surgeries and were diagnosed with adenoid cystic carcinoma of the external auditory canal by pathology. They were admitted to the First Affiliated Hospital of Nanjing Medical University from June 2007 to March 2019. The risk factors of distant metastasis and their influence on prognosis were analyzed by univariate and multivariate analyses. Results The rate of distant metastasis in this group was 40.9%, and the incidence of lung metastasis was the highest(66.7%). Univariate analysis showed that positive surgical margin and lymphatic metastasis during the operation were related to distant metastasis of adenoid cystic carcinoma of external auditory canal(P<0.05). Multivariate regression analysis showed that positive surgical margin and lymphatic metastasis were significantly associated with distant metastasis(P<0.05). The 5-year and 10-year overall survival rates of patients with adenoid cystic carcinoma of the external auditory canal who developed distant metastasis were 44.4% and 16.7%, respectively, while those without distant metastasis had 100% 5-year and 10-year survival rates. The difference was statistically significant(P<0.05). Conclusion Adenoid cystic carcinoma of the external auditory canal has a higher rate of distant metastasis, with predominant lung metastasis. Positive surgical margin and lymphatic metastasis were were independent risk factors for distant metastasis, which is an important indicator affecting the prognosis of patients with the tumor.

Key words: Adenoid cystic carcinoma, External auditory canal, Distant metastasis, Prognosis

CLC Number: 

  • R739.61
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