Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 1-6.doi: 10.6040/j.issn.1673-3770.0.2020.087

    Next Articles

Analysis of distant metastasis and prognosis of adenoid cystic carcinoma of the external auditory canal

WANG Yingying, ZHOU Han, DONG Weida, XING Guangqian, CHEN Zhibin, ZHANG Qingzhao, ZHANG Liqing   

  1. Department of Otolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nangjing 210029, Jiangsu, China
  • Published:2021-02-01

PDF (PC)

258

Abstract: Objective This study aimed to investigate the risk factors of distant metastasis of adenoid cystic carcinoma of the external auditory canal and its influence on prognosis. Methods We performed a retrospective analysis of the clinical data and follow-up information of 22 patients who underwent radical surgeries and were diagnosed with adenoid cystic carcinoma of the external auditory canal by pathology. They were admitted to the First Affiliated Hospital of Nanjing Medical University from June 2007 to March 2019. The risk factors of distant metastasis and their influence on prognosis were analyzed by univariate and multivariate analyses. Results The rate of distant metastasis in this group was 40.9%, and the incidence of lung metastasis was the highest(66.7%). Univariate analysis showed that positive surgical margin and lymphatic metastasis during the operation were related to distant metastasis of adenoid cystic carcinoma of external auditory canal(P<0.05). Multivariate regression analysis showed that positive surgical margin and lymphatic metastasis were significantly associated with distant metastasis(P<0.05). The 5-year and 10-year overall survival rates of patients with adenoid cystic carcinoma of the external auditory canal who developed distant metastasis were 44.4% and 16.7%, respectively, while those without distant metastasis had 100% 5-year and 10-year survival rates. The difference was statistically significant(P<0.05). Conclusion Adenoid cystic carcinoma of the external auditory canal has a higher rate of distant metastasis, with predominant lung metastasis. Positive surgical margin and lymphatic metastasis were were independent risk factors for distant metastasis, which is an important indicator affecting the prognosis of patients with the tumor.

Key words: Adenoid cystic carcinoma, External auditory canal, Distant metastasis, Prognosis

CLC Number: 

  • R739.61
[1] International Head and Neck Scientific Group. Cervical lymph node metastasis in adenoid cystic carcinoma of the sinonasal tract, nasopharynx, lacrimal glands and external auditory canal: a collective international review[J]. J Laryngol Otol, 2016, 130(12): 1093-1097. doi:10.1017/s0022215116009373.
[2] Lee BJ, Bae SC, Lee JH, et al. A case of basal cell carcinoma of external auditory canal[J]. Korean J Audiol, 2012, 16(2): 91. doi:10.7874/kja.2012.16.2.91.
[3] Amit M, Na'ara S, Trejo-Leider L, et al. Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: an international collaborative study[J]. Head Neck, 2017, 39(5): 1008-1014. doi:10.1002/hed.24740.
[4] Unsal AA, Chung SY, Zhou AH, et al. Sinonasal adenoid cystic carcinoma: a population-based analysis of 694 cases[J]. Int Forum Allergy Rhinol, 2017, 7(3): 312-320. doi:10.1002/alr.21875.
[5] Subramaniam T, Lennon P, O'Neill JP. Ongoing challenges in the treatment of adenoid cystic carcinoma of the head and neck[J]. Ir J Med Sci, 2015, 184(3): 583-590. doi:10.1007/s11845-015-1298-1.
[6] Zhang Yibo, Liu Hongyan, Wu Qianru, et al. Predictors of distant metastasis and survival in adenoid cystic carcinoma of the external auditory canal[J]. Otol Neurotol, 2019, 40(10):e1006-e1011. doi: 10.1097/MAO.0000000000002391.
[7] Bonaparte JP, Trites J, Hart R, et al. Survival when treating adenoid cystic carcinoma of the external auditory canal: Quantitative assessment of case reports[J]. Journal of Otolaryngology-Head and Neck Surgery, 2009, 38(4): 468-476.
[8] Amit M, Binenbaum Y, Sharma K, et al. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study[J]. Head Neck, 2014, 36(7): 998-1004. doi:10.1002/hed.23405.
[9] Gao M, Hao Y, Huang MX, et al. Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma[J]. Int J Oral Maxillofac Surg, 2013, 42(8): 923-928. doi:10.1016/j.ijom.2013.04.006.
[10] 高燕, 杨慧, 陈飞, 等. 外耳道腺样囊性癌的临床诊治分析[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(21): 1660-1664. doi:10.13201/j.issn.1001-1781.2018.21.013. GAO Yan, YANG Hui, CHEN Fei, et al. Clinical diagnosis and treatment of adenoid cystic carcinoma of the external auditory canal[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(21): 1660-1664. doi:10.13201/j.issn.1001-1781.2018.21.013.
[11] 冯剑, 周涵, 宋圣花, 等. 鼻腔鼻窦腺样囊性癌15例临床分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 87-91. doi:10.6040/j.issn.1673-3770.0.2018.545. FENG Jian, ZHOU Han, SONG Shenghua, et al. Clinical analysis of 15 cases of adenoid cystic carcinoma in the paranasal sinuses and nasal cavity[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 87-91.doi:10.6040/j.issn.1673-3770.0.2018.545.
[12] Girelli L, Locati L, Galeone C, et al. Lung metastasectomy in adenoid cystic cancer: Is it worth it?[J]. Oral Oncol, 2017, 65: 114-118. doi:10.1016/j.oraloncology.2016.10.018.
[13] Vishnu Prasad, Vijendra SS, Raghavendra A R. Adenoid cystic carcinoma- a rare differential diagnosis for a mass in the external auditory canal[J]. J Clin Diagn Res. 2015,9(1):MD01-2. doi: 10.7860/JCDR/2015/10374.5369.
[14] Liu HY, Zhang YB, Zhang T, et al. Correlation between the pathology and clinical presentations in patients with adenoid cystic carcinoma of the external auditory canal[J]. Head Neck, 2017,39(12): 2444-2449. doi:10.1002/hed.24915.
[15] Ebelhar AE, West DS, Aouad RK. Ceruminous adenoid cystic carcinoma of external auditory canal[J]. Int Adv Otol, 2017, 13(2): 292-294. doi:10.5152/iao.2017.3929.
[16] International Head and Neck Scientific Group. Cervical lymph node metastasis in adenoid cystic carcinoma of the major salivary glands[J]. J Laryngol Otol, 2017, 131(2): 96-105. doi:10.1017/s0022215116009749.
[17] Dillon PM, Chakraborty S, Moskaluk CA, et al. Adenoid cystic carcinoma: a review of recent advances, molecular targets, and clinical trials[J]. Head Neck, 2016, 38(4): 620-627. doi:10.1002/hed.23925. doi: 10.1093/jrr/rrz010.
[18] Takuya Nagano, Ryo-Ichi Yoshimura, Mio Kojima, et al. Outcomes of radiotherapy in advanced external auditory canal cancer[J]. Journal of radiation research, 2019, 60(3):380-386.
[19] Holliday E, Bhattasali O, Kies MS, et al. Postoperative intensity-modulated proton therapy for head and neck adenoid cystic carcinoma[J]. Int J Part Ther,2016, 2(4):533-543. doi:10.14338/ijpt-15-00032.1.
[1] CHENG Yao, ZHANG Zhen, YANG Ji, FENG Chengmin, DENG Qicheng, ZHANG Xi, ZHAO Rui, ZHU Xin, WU Junzhi, LIU Hai, DENG Shishan. Expression and clinical significance of CIP2A in hypopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 40-44.
[2] LIU Pan, WANG Chuan, ZHAO Zeqi, WU Mei, XU Jifeng, LI Wei, ZHANG Weiqiang, LIU Wen. Five cases of metastatic clear cell carcinoma of the head and neck: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(4): 45-50.
[3] WANG Zhongwei, YANG Lin, GUO Ya, SUN Bin, WANG Yali, MA Xiulong, REN Hongtao, BAO Xing. Analysis of the relationship between miR-429 and miR-200C expression and prognosis in patients with nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 81-86.
[4] TAN Yufang, YI Tianhua. Clinical characteristics and prognosis of sudden sensorineural hearing loss in post-irradiated nasopharyngeal carcinoma survivors: a report of 18 cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 35-39.
[5] GUO Fang, ZHANG Dejun, FU Zeming, GUO Yingyuan, WAN Yining, GUAN Guofang. Cholesteatoma of the external auditory canal complicated with suppurative parotitis: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 12-15.
[6] This study aims to evaluate the level of expression of cyclin E2 in hypopharyngeal cancer and its relationship with clinical characteristics as well as prognosis. MethodsThe protein levels of cyclin E2 in tumor tissues and adjacent normal tissues were assessed by immunohistochemistry staining in 50 cases of hypopharyngeal cancer. The relationship between the expression level of cyclin E2 and clinical data was analyzed using the SPSS software. ResultsProtein levels of cyclin E2 in hypopharyngeal cancer were higher than protein levels of cyclin E2 in normal tissue(Z=-5.764,P=0.000). The cyclin E2 level in tumor tissue correlated with the tumor staging(Z=-1.995, P=0.046)and lymph node metastasis(Z=-2.176, P=0.030). The 5-year survival rates of patients with cyclin E2 positive and negative expression were 40.2% and 81.8%, respectively. Patients with high expression levels of cyclin E2 had a lower survival rate(χ=6.317, P=0.012). ConclusionThe abnormal expression of cyclin E2 protein in tumor tissues indicates that cyclin E2 may be involved in the development of hypopharyngeal cancer and could be a potential diagnostic and prognostic molecular marker.. Expression of cyclin E2 in hypopharyngeal cancer and its clinical significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 132-137.
[7] Rhinogenic headache is caused by rhinosinusitis or abnormal nasal anatomy. Currently, there are clear classifications and pain grading standards to diagnose the same. Further, its mechanism of action is now understood to involve trigeminal nerve stimulation and sensory neuropeptide substance P. Functional endoscopic surgery(FESS)is prioritized as a treatment modality. During surgery, it is imperative to restore the normal anatomy of the nasal cavity. Several clinical studies have reported that FESS was significantly effective in treating rhinogenic headache, with an overall effective rate of 90% and cure rate of 78%. Additionally, one report indicates that postoperative endoscopic examination and dressing change can effectively reduce the occurrence of complications and ensure safety of the treatment.. Dynamic analysis of rhinogenic headacheZHOU Fangming1, XIE Yan2, LIU Yang2 Overview JIANG Luyun2〓Guidance 1. Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China 2. Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 130-133.
[8] XU Jinjing, HU Jinghua, WU Yuanqing, DENG Yi, YU Weiwei. Applications of CO2 laser microsurgery on laryngeal precancerous lesions and early glottic laryngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(3): 129-133.
[9] CHEN Huijun, SONG Shenghua, DONG Weida, ZHOU Han. Prognostic role of preoperative fibrinogen levels in patients with laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(2): 110-114.
[10] Yujing DING,Lan LAN,Qiuju WANG,Fei JI,Fen XIONG,Linyi XIE,Haina DING,Yin XIA,Hui ZHAO. Analysis of clinical characteristics and prognosis of post traumatic hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 9-14.
[11] ZONG Xiaofang, HU Guohua, ZHONG Shixun, LEI Yan, JIANG Lizhu, KANG Houyong. Analysis of the factors affecting the prognosis of low-frequency descending sudden hearing loss without vertigo [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 33-37.
[12] CHEN Xuesong, FU Weiwei, LIU Jiangtao. The prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intensity modulated radiation therapy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 50-53.
[13] Yangfan LIU,Jian JIA,Baoluo WAN. A retrospective study on clinic manifestation and pathological of the larynx leukoplakia in 76 cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 162-165.
[14] Jian FENG,Han ZHOU,Shenghua SONG,Qing ZHAO,Jiacheng ZHANG,Yaqin LIU,Yujie SHEN,Weida DONG. Clinical analysis of 15 cases of adenoid cystic carcinoma in the paranasal sinuses and nasal cavity [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 87-91.
[15] Ruofei HUANG,Lixiao CHEN,Xinwei CHEN,Ziwei YU,Bin JIN,Jiangcai ZHU,Pin DONG. Recurrent laryngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 36-39.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 84 -87 .
[2] NIU Shanli,CHAI Maowen,LI Zhenxiu . Endoscopic rhinoplasty of inferior turbinate in 60 patients with chronic hypertrophic rhinitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 16 -18 .
[3] MENG Qing-guo,LU Yong-tian,FAN Xian-liang .

Association of killer cell immunoglobulin-like receptor gene polymorphisms with nasopharyngeal carcinoma

[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 196 -199 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 199 -199 .
[5] WAN Li-jia,LU Hai-tao,JIANG Yi-dao,LIU Hui,LI Qin,SHE La-zhi . Effect of H-uvulopalatopharyngoplasty on obstructive sleep apnea
hypopnea syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 204 -205 .
[6] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 222 -224 .
[7] JI Xiao-bin,DENG Jia-de,ZANG Lin-quan,WANG Lei,XIE Jun . Blood histamine in guinea pigs with allergic rhinitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 228 -230 .
[8] XIANG Deng,LU Yong-tian,SUN Huan-ji . Endoscopic repair for cerebrospinal fluid rhinorrhea in 19 cases and a literature review [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 234 -236 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 253 -257 .
[10]
YIN Guo-hua,ZHONG Xiao . Long-term effect of laser reduction on lingua adenoids
[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 280 -282 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd