Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (1): 75-80.doi: 10.6040/j.issn.1673-3770.0.2021.028

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Clinical research of subcutaneous immunotherapy on children with allergic asthma caused by dust mites and combined with mold allergen

LI Menghui1,3, ZHI Lili2, QI Kaiwen3,4, WANG Shanshan3, GAO Qian1,3, BU Meiling1,3,   

  1. 1. Second Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan 250004, Shandong, China;
    2. Zibo Central Hospital Allergy Department of, Zibo 255036, Shandong, China;
    3. Shandong Provincial Hospital of Shandong First Medical University Department of Pediatric Respiratory, Jinan 250021, Shandong, China;
    4. Weifang Medical College, Weifang 261053, Shandong, China
  • Published:2022-02-22

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Abstract: Objective To evaluate the efficacy of subcutaneous immunotherapy(SCIT)on children with allergic asthma caused by single dust mite and dust mite with mold respectively. Methods Children aged 6-14 years with allergic asthma were divided into single dust mite allergy group or dust mite with mold allergy group according to allergen species and given SCIT. ACQ score, drug score, lung function indicators(FEV1%, FEF50%, FEF75% and MMEF%)were compared after 12,24 months of treatment within and between groups, respectively. Results A total of 118 asthmatic children were included: 57 in the dust mite group and 61 in the dust mite with mold group. After 12 months of treatment, ACQ score, drug score, FEF50%, FEF75% and MMEF% were significantly improved compared with that before treatment in both groups(all P<0.05). While the FEV1% in both groups were improved compared with that before treatment, but there was no statistical significance(P>0.05). After 24 months of treatment, both groups of ACQ score, drug score, FEV1%,FEF50%,FEF75% and MMEF% have improved significantly of that after 12 months of treatment(all P<0.05). At 12 and 24 months of treatment, there were no significant differences of degree of improvement in ACQ score, drug score, FEV1%, FEF50%, FEF75% and MMEF%(all P>0.05)between two groups. Conclusion The SCIT can significantly improve the clinical symptoms, reduce the use of symptomatic drugs, improve lung function in children with allergic asthma. SCIT not only has a significant effect on single dust mite, but also on dust mite with mold allergen.

Key words: Specific immunotherapy, Children, Asthma, Mold allergen

CLC Number: 

  • R562.2
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