Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (1): 75-80.doi: 10.6040/j.issn.1673-3770.0.2021.028

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Clinical research of subcutaneous immunotherapy on children with allergic asthma caused by dust mites and combined with mold allergen

LI Menghui1,3, ZHI Lili2, QI Kaiwen3,4, WANG Shanshan3, GAO Qian1,3, BU Meiling1,3,   

  1. 1. Second Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan 250004, Shandong, China;
    2. Zibo Central Hospital Allergy Department of, Zibo 255036, Shandong, China;
    3. Shandong Provincial Hospital of Shandong First Medical University Department of Pediatric Respiratory, Jinan 250021, Shandong, China;
    4. Weifang Medical College, Weifang 261053, Shandong, China
  • Published:2022-02-22

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Abstract: Objective To evaluate the efficacy of subcutaneous immunotherapy(SCIT)on children with allergic asthma caused by single dust mite and dust mite with mold respectively. Methods Children aged 6-14 years with allergic asthma were divided into single dust mite allergy group or dust mite with mold allergy group according to allergen species and given SCIT. ACQ score, drug score, lung function indicators(FEV1%, FEF50%, FEF75% and MMEF%)were compared after 12,24 months of treatment within and between groups, respectively. Results A total of 118 asthmatic children were included: 57 in the dust mite group and 61 in the dust mite with mold group. After 12 months of treatment, ACQ score, drug score, FEF50%, FEF75% and MMEF% were significantly improved compared with that before treatment in both groups(all P<0.05). While the FEV1% in both groups were improved compared with that before treatment, but there was no statistical significance(P>0.05). After 24 months of treatment, both groups of ACQ score, drug score, FEV1%,FEF50%,FEF75% and MMEF% have improved significantly of that after 12 months of treatment(all P<0.05). At 12 and 24 months of treatment, there were no significant differences of degree of improvement in ACQ score, drug score, FEV1%, FEF50%, FEF75% and MMEF%(all P>0.05)between two groups. Conclusion The SCIT can significantly improve the clinical symptoms, reduce the use of symptomatic drugs, improve lung function in children with allergic asthma. SCIT not only has a significant effect on single dust mite, but also on dust mite with mold allergen.

Key words: Specific immunotherapy, Children, Asthma, Mold allergen

CLC Number: 

  • R562.2
[1] 中华医学会变态反应分会呼吸过敏学组(筹), 中华医学会呼吸病学分会哮喘学组. 中国过敏性哮喘诊治指南(第一版, 2019年)[J]. 中华内科杂志, 2019, 58(9): 636-655. doi:10.3760/cma.j.issn.0578-1426.2019.09.004. The Respiratory Allergy Group of Chinese Society of Allergy, The Asthma Group of Chinese Thoracic Society, Chinese Medical Association.Chinese guidelines for the diagnosis and treatment of allergic asthma(2019, the first edition)[J]. Chin J Intern Med, 2019, 58(9): 636-655. doi:10.3760/cma.j.issn.0578-1426.2019.09.004.
[2] Twaroch TE, Curin M, Valenta R, et al. Mold allergens in respiratory allergy: from structure to therapy[J]. Allergy Asthma Immunol Res, 2015, 7(3): 205-220. doi:10.4168/aair.2015.7.3.205.
[3] Salo PM, Arbes SJ, Jaramillo R, et al. Prevalence of allergic sensitization in the United States: results from the national health and nutrition examination survey(NHANES)2005-2006[J]. J Allergy Clin Immunol, 2014, 134(2): 350-359. doi:10.1016/j.jaci.2013.12.1071.
[4] Schaller A, Delmas C, De Blay F. Allergic respiratory diseases related to mould in the home[J]. Rev Mal Respir, 2019, 36(7): 889-901. doi:10.1016/j.rmr.2018.10.619.
[5] 赵晨, 王岑岑, 赵晓波, 等. 556例过敏性疾病患儿血清过敏原检测结果分析[J]. 中国临床医生杂志, 2019, 47(1): 102-105. doi:10.3969/j.issn.2095-8552.2019.01.033.
[6] 中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童支气管哮喘诊断与防治指南(2016年版)[J]. 中华儿科杂志, 2016, 54(3): 167-181. doi:10.3760/cma.j.issn.0578-1310.2016.03.003. The Subspecialty Group of Respiratory Diseases, The Society of Pediatrics, Chinese Medical Association, The Editorial Board, Chinese Journal of Pediatrics.Guideline for the diagnosis and optimal management of asthma in children(2016)[J]. Chin J Pediatr, 2016, 54(3): 167-181. doi:10.3760/cma.j.issn.0578-1310.2016.03.003.
[7] Nguyen JM, Holbrook JT, Wei CY, et al. Validation and psychometric properties of the Asthma Control Questionnaire among children[J]. J Allergy Clin Immunol, 2014, 133(1): 91-97. e1-6. doi:10.1016/j.jaci.2013.06.029.
[8] Pfaar O, Demoly P, Gerth van Wijk R, et al. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper[J]. Allergy, 2014, 69(7): 854-867. doi:10.1111/all.12383.
[9] 中华医学会儿科学分会呼吸学组肺功能协作组.肺功能系列指南(二):肺容积和通气功能[J].中华实用儿科临床杂志, 2016, 31(10):744-750. doi:10.3760/cma.j.issn.2095-428X.2016.10.006.
[10] Li J, Sun B, Huang Y, et al. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009, 64(7): 1083-1092. doi:10.1111/j.1398-9995.2009.01967.x.
[11] 王洁, 常换换, 魏苗, 等. 舌下含服尘螨滴剂治疗单一或多重过敏原儿童变应性鼻炎的疗效观察[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(21): 1646-1650. doi:10.13201/j.issn.1001-1781.2018.21.010. WANG Jie, CHANG Huanhuan, WEI Miao, et al. Effect of sublingual dust mite drops on single or multiple allergens allergic rhinitis in children[J]. J Clin Otorhinolaryngol Head Neck Surg, 2018, 32(21): 1646-1650. doi:10.13201/j.issn.1001-1781.2018.21.010.
[12] Khamal R, Isa ZM, Sutan R, et al. WITHDRAWN: indoor particulate matters, microbial count assessments and wheezing symptoms among toddlers in urban day care centers(DCCs)in the district ofseremban, Malaysia[J]. Ann Glob Heal, 2017. doi:10.1016/j.aogh.2016.05.004.
[13] 徐盼盼, 纪东, 程静, 等. 安脱达治疗单一尘螨和多重过敏的变应性鼻炎的疗效分析[J]. 中国中西医结合耳鼻咽喉科杂志, 2017, 25(3): 200-204. doi:10.16542/j.cnki.issn.1007-4856.2017.03.012. XU Panpan, JI Dong, CHEN Jing, et al. Efficacy analysis of Alutard SQ with Dermatophagoides pteronyssinus preparations in monosensitized and polysensitized patients with allergic rhinitis[J]. Chin J Otorhinolaryngol Integr Med, 2017, 25(3): 200-204. doi:10.16542/j.cnki.issn.1007-4856.2017.03.012.
[14] 屠燕怡, 史丽, 赵莉, 等. 尘螨疫苗皮下注射治疗变应性鼻炎的疗效和安全性评估[J]. 山东大学耳鼻喉眼学报, 2016, 30(4): 50-55. doi:10.6040/j.issn.1673-3770.0.2016.292. TU Yanyi, SHI Li, ZHAO Li, et al. Efficacy and safety of subcutaneous immunotherapy with house dust mite extract for allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2016, 30(4): 50-55. doi:10.6040/j.issn.1673-3770.0.2016.292.
[15] Smith CJ, Spaeder MC, Sorkness RL, et al. Disparate diagnostic accuracy of lung function tests as predictors of poor asthma control in children[J]. J Asthma, 2020, 57(3): 327-334. doi:10.1080/02770903.2019.1566471.
[16] Jones MH, Howard J, Davis S, et al. Sensitivity of spirometric measurements to detect airway obstruction in infants[J]. Am J Respir Crit Care Med, 2003, 167(9): 1283-1286. doi:10.1164/rccm.200204-339OC.
[17] Siroux V, Boudier A, Dolgopoloff M, et al. Forced midexpiratory flow between 25% and 75% of forced vital capacity is associated with long-term persistence of asthma and poor asthma outcomes[J]. J Allergy Clin Immunol, 2016, 137(6): 1709-1716.e6. doi:10.1016/j.jaci.2015.10.029.
[18] Asamoah F, Kakourou A, Dhami S, et al. Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews[J]. Clin Transl Allergy, 2017, 7: 25. doi:10.1186/s13601-017-0160-0.
[19] 吴少皎, 陈实, 陈冰, 等. 屋尘螨皮下特异性免疫治疗对儿童过敏性哮喘伴鼻炎肺功能及症状的影响分析[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(17): 1352-1355. doi:10.13201/j.issn.1001-1781.2017.17.014. WU Shaojiao, CHEN Shi, CHEN Bing, et al. An analysis of the subcutaneous immunotherapy on the pulmonary function and symptoms of asthma and rhinitis in children[J]. J Clin Otorhinolaryngol Head Neck Surg, 2017, 31(17): 1352-1355. doi:10.13201/j.issn.1001-1781.2017.17.014.
[20] 邓文华, 陈锋. 吸入性糖皮质激素联合长效β2受体激动剂治疗肥胖儿童哮喘的疗效分析[J]. 中国处方药, 2020, 18(4): 72-73.
[21] 容嘉妍, 黄东明, 王桂兰, 等. 屋尘螨皮下特异性免疫治疗儿童哮喘和/或变应性鼻炎致全身不良反应[J]. 中华临床免疫和变态反应杂志, 2020, 14(3): 233-238. doi:10.3969/j.issn.1673-8705.2020.03.010. RONG Jiayan, HUANG Dongming, WANG Guilan, et al. Systemic adverse reactions induced by house dust mite specific immunotherapy among children with asthma and/or allergic rhinitis[J]. Chin J Allergy Clin Immunol, 2020, 14(3): 233-238. doi:10.3969/j.issn.1673-8705.2020.03.010.
[22] Cheng L, Chen J, Fu Q, et al. Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis[J]. Allergy Asthma Immunol Res, 2018, 10(4): 300-353. doi:10.4168/aair.2018.10.4.300.
[23] Har D, Lee MJ. Systemic reaction rates with omalizumab, subcutaneous immunotherapy, and combination therapy in children with allergic asthma[J]. Allergy Asthma Proc, 2019, 40(1): 35-40. doi:10.2500/aap.2019.40.4173.
[24] 钟灿, 杨伟忠, 黎月莲, 等. 舌下含服粉尘螨滴剂治疗多重过敏的过敏性哮喘的临床评价[J]. 临床肺科杂志, 2016, 21(7): 1194-1198. doi:10.3969/j.issn.1009-6663.2016.07.008. ZHONG Can, YANG Weizhong, LI Yuelian, et al. Clinical evaluation of sublingual immunotherapy with Dermatophagoides farinae drops in polysensitized patients with allergic asthma[J]. J Clin Pulm Med, 2016, 21(7): 1194-1198. doi:10.3969/j.issn.1009-6663.2016.07.008.
[25] 许晨霞, 张妙莲, 邹泽红, 等. 螨制剂舌下免疫治疗对单一和多重致敏变应性鼻炎的疗效评估[J]. 中华临床免疫和变态反应杂志, 2014, 8(2): 95-100. doi:10.3969/j.issn.1673-8705.2014.02.002. XU Chenxia, ZHANG Miaolian, ZOU Zehong, et al. Clinical evaluation of efficacy of sublingual immunotherapy with Dermatophagoides farinae extract among monosensitized and polysensitized patients with allergic rhinitis[J]. Chin J Allergy Clin Immunol, 2014, 8(2): 95-100. doi:10.3969/j.issn.1673-8705.2014.02.002.
[26] Marogna M, Spadolini I, Massolo A, et al. Effects of sublingual immunotherapy for multiple or single allergens in polysensitized patients[J]. Ann Allergy Asthma Immunol, 2007, 98(3): 274-280. doi:10.1016/S1081-1206(10)60718-1.
[27] von Hertzen LC, Savolainen J, Hannuksela M, et al. Scientific rationale for the Finnish Allergy Programme 2008-2018: emphasis on prevention and endorsing tolerance[J]. Allergy, 2009, 64(5): 678-701. doi:10.1111/j.1398-9995.2009.02024.x.
[28] Agache I, Lau S, Akdis CA, et al. EAACI Guidelines on Allergen Immunotherapy: House dust mite-driven allergic asthma[J]. Allergy, 2019, 74(5): 855-873. doi:10.1111/all.13749.
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