Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 36-42.doi: 10.6040/j.issn.1673-3770.0.2021.565

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Research advances of dupilumab in the treatment of chronic rhinosinusitis with nasal polyps

SHI Shuai1, ZHENG Quan1Overview,CHENG Lei2   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian 223800, Jiangsu, China;
    2. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Published:2022-06-15

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Abstract: Chronic rhinosinusitis(CRS)is a common inflammatory disease of the paranasal sinus mucosa. Complex mechanisms lead to a strongly heterogeneous CRS, and some patients do not find relief using the current standard drug treatment and surgery. CRS has different inflammatory endotypes and clinical phenotypes; CRS with nasal polyps(CRSwNP)has always been difficult to treat, as its symptoms are relatively severe and often complicated by asthma. It is often unresponsive to conventional drugs and surgery and has a high risk of reoccurring. In recent years, dupilumab has been found to be effective in adult intractable CRSwNP by blocking the signal transduction of interleukin(IL)-4 and IL-13, which are the key driving factors in type II inflammation. Currently, the study of dupilumab in the treatment of CRSwNP in China has not been reported. This article reviews the progress achieved in the research of dupilumab in the treatment of CRSwNP, to provide a reference for its further application and research in treating CRSwNP.

Key words: Chronic rhinosinusitis with nasal polyps, Biologics, Dupilumab, Type II inflammation, IL-4Rα

CLC Number: 

  • R765.41
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