Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 20-29.doi: 10.6040/j.issn.1673-3770.0.2021.561

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Advances in endotypes and precision medicine in chronic rhinosinusitis

YAO Shuang1,2Overview,LOU Hongfei3,4   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China;
    2. Beijing Key Laboratory of Nasal Diseases and Beijing Laboratory of Allergic Diseases/Beijing Institute of Otolaryngology, Beijing 100005, China;
    3. Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China;
    4. Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences(Beijing TongRen Hospital, Capital Medical University), Beijing 1000730, China
  • Published:2022-06-15

Abstract: Chronic rhinosinusitis(CRS)has complex pathogenesis and a high degree of heterogeneity, with some types responding poorly to conventional therapy. Therefore, clinicians should have an in-depth understanding of endotypes and promote precision medicine with biologics as core management for CRS. In this study, we aimed to review endotypes and corresponding biologic treatment of CRS to clarify the importance of both in precision medicine. We provide a reference framework for establishing and improving individualized treatment strategies for CRS.

Key words: Chronic rhinosinusitis, Heterogeneity, Endotypes, Biologics, Precision medicine

CLC Number: 

  • R765.4
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