Abstract: Objective To explore effective therapies for keratosis of the larynx, a pre-malignant precursor of squamous cell carcinoma. Methods From 2000 to 2003, 30 patients with keratosis of the larynx were given combined therapies which were mainly anticornification drugs, ancillary drugs, humidification treatment and surgery. Results All the patients were followed up from 1 to 5 years. Complete remission was observed in 25 of 30 patients (83.3%), partial response was seen in 1 patient and recurrence in 2. Meanwhile progression to carcinoma occurred in 2 cases. Conclusions These combined therapies have advantages of easy procedure, good effect and minor injury for keratosis of the larynx.

Key words: Keratosis of larynx, Anti-cornification drugs, Combined therapy, Precancerosis