Abstract: To explore the growth of corneal neovascularization induced by suture and alkali burn and to explore expression of vascular endothelial growth factor (VEGF). MethodsAll animals(n=75) were randomly divided into three groups: the control group (5 rabbits), the suture group（35 rabbits) and the alkali burn group (35 rabbits). Biomicroscopic features including length and area of corneal neovascularization were observed.　Immunoreaction of VEGF was detected on the 1st，　 2nd, 3rd， 5th， 7th， 10th an 14th day after the operations.　ResultsCorneal neovascularization began to invade the cornea on day 3 and flourished on day 7， then reached its developmental peak on day 10， and gradually regressed after day 14. The CNV area of the suture group was significantly smaller than that of the alkali burn group. In CNV tissues, positive immune reaction of VEGF was most apparent during the 3rd to the 7th day, and then remarkably declined on the 10th day. But positive immune reaction of VEGF of the sutureinduced group declined more quickly than that of the alkali burn group. ConclusionIn this study, alkali burn induced more CNV, which slowly declined, and suture had better controllability for area of CNV.