JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2011, Vol. 25 ›› Issue (2): 7-9.

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Correlation between obstructive sleep apnea hypopnea  syndrome and  kidney damage

ZHANG Jin-hui, JIANG Guang-feng，LI Wei   

  1. Department of Otolaryngology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong, China
  • Received:2010-10-11 Revised:2010-12-11 Online:2011-04-16 Published:2011-04-16

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Abstract:

Objective    To study the correlation of obstructive sleep apnea hypopnea syndrome(OSAHS) with serum uric acid(UA), serum creatinine(Scr) and blood urea nitrogen(Bun) concentrations. Methods    100 patients with moderate and severe OSAHS and 44 control subjects admitted into our hospital were recruited. The differences of the levels of UA, Scr and Bun among each group were analyzed. Also, the correlations between the apnea hypopnea index (AHI), lowest saturation of blood oxygen (LSaO2) and UA, Scr, Bun were analyzed.  Results     The levels of UA and Scr were significantly higher in groups with moderate or severe OSAHS than those in the control group (P<0.05). UA was positively correlated with AHI (P<0.05), but negatively correlated with LSaO2 (P<0.05). Conclusion    Concentrations of UA and Scr increase with AHI and the degree of anoxemia in patients with moderate and severe OSAHS. High levels of UA and Scr demonstrate that OSAHS is to a certain extent associated with kidney damage. 

Key words: Sleep apnea hypopnea syndrom, obstructive; Uric acid; Creatinine; Kidney damage

CLC Number: 

  • R766.7
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