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Table of Content

    24 February 2007 Volume 21 Issue 1
      
    Articles
    Surgical treatment for medial wall pyriform sinus cancer
    LIU Da-yu,PAN Xin-liang,LEI Da-peng,ZHANG Li-qiang,LUAN Xin-yong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  8-11 . 
    Abstract ( 2399 )   PDF (275KB) ( 1594 )   Save
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    Objective:To study the surgical technique and results of surgical treatment for medial wall pyriform sinus cancer. Methods: A total of 122 patients with medial wall pyriform sinus cancer were surgically treated in our department between 1990 and 2001. Among them, 5 were in stage Ⅰ, 8 in stage Ⅱ, 37 in stage Ⅲ, and 72 in stage Ⅳ. Partial resection of the pyriform sinus and partial laryngectomy were performed on 87 cases. Epiglottis and sternohyoid myofascial flaps were used for laryngeal reconstruction. The remaining hypopharyngeal mucosa, pectoralis major musculocutaneous flap and colon interposition were used to cover the wound of hypopharynx and for artificial rebuilding. All patients received postoperative radiotherapy. Results:The overall 3 and 5year survival rates were 67.2%(82/122)and 45.1%(55/122), respectively. In the preservative surgery group, the 3  and 5year survival rates were 71.3%(62/87) and 48.3%(42/87), respectively, whereas those in the total laryngectomy group were 57.1%(20/35)and 37.1%(13/35), respectively. Laryngeal functions were completely restored in 71.3%(62/87) and partially in 28.7% (25/87)of the total laryngectomy group. Conclusion: Although the medial wall pyriform sinus cancer tends to have a laryngeal invasion, preservative surgery should be practiced for the majority of patients after the lesions have been entirely removed.
    Reconstruction of the hypopharynx with a fascial flap of the strap muscles in hypopharyngeal cancer
    SONG Xi-cheng,ZHANG Qing-quan,SUN Yan,WANG Qiang,WANG Li,ZHANG Hua,JIANG Shao-hong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  12-14 . 
    Abstract ( 1958 )   PDF (255KB) ( 1698 )   Save
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    Objective: To investigate the methods with a fascial flap of the strap muscles in reconstruction for hypopharyngeal carcinoma. Methods: Nine patients with hypopharyngeal cancer (stage Ⅱ, 1; stage Ⅲ, 4; and stage Ⅳ, 4; according to the UICC 2002 staging criteria) were surgically treated from June 1987 to June 1997. Lateral pharynx approaches were chosen based on the condition of process to perform the ablation of tumors, and fascial flap/muscular flap/ muscularfascial flap of the strap muscles were used to repair the defects and reconstruct the functions of larynx and pharynx. Adjutant radiation therapy of 6080Gy was performed on all cases. Results: All repair materials used were alive. One case suffered from postoperative wound infection and healed after constant rinsing and dressing changes. Two cases suffered from pharyngeal fistula and healed after dressing changes, rinsing and pressurizing. All patients′ laryngeal functions were preserved. All patients recovered diet within 12 to 35 days, with a mean time of 16.3 days. No pharyngosterosis and esophagostenosis happened. The 3 and 5year survival rates were 66.7%(6/9) and 44.4%(4/9), respectively. Conclusion: It is an available way to repair the defect of the hypopharyngeal paries anterior and the base of tongue with fascial flap/muscularflap/ muscularfascial flap of the strap muscles.
    Surgical treatment for posterior hypopharyngeal wall carcinoma
    YUAN Ying,PAN Xin-liang,LUAN Xin-yong,XU Feng-lei,LIU Da-yu,LEI Da-peng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  15-19 . 
    Abstract ( 2654 )   PDF (301KB) ( 1559 )   Save
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    Objective:To study the surgical treatment and the simultaneous reconstruction methods for posterior hypopharyngeal wall carcinoma. Methods: Thirtyfive cases of the posterior hypopharyngeal wall carcinoma were retrospectively reviewed. According to UICC 1997 criteria, there were 2 in stageⅠ, 7 in stage Ⅱ, 10 in stage Ⅲ, and 16 in stage Ⅳ. Twenty cases preserved the complete or partial laryngeal functions and 15 cases accepted the total laryngectomy. Nineteen cases underwent an unilateral elective or modified radical neck dissection and 15 underwent a bilateral neck dissection. Thirtythree patients received radiotherapy postoperatively (5070?Gy). Results: The deglutition function was restored within 2 months. Vocal function was acquired in 20 patients preserving the laryngeal function and trachea cannulas were removed in 15 patients. The 5 and 3year survival rates were 31.6%(6/19)and 44.4%(12/27), respectively. Conclusion: Carcinoma of the posterior hypopharyngeal wall are few in clinic. Surgical resection and onestage hypopharyngeal reconstruction are feasible. The pharyesophagus passage could be restored by retaining the mucosa, pectoralis major myocutaneous flap, laryngotracheal flap, split skin flap, stomach transposition and colon interposition etc.
    Influence of firecrackers′ impulse noise on auditory function
    GAO Xia,Fleischer Grald,DING Xiao-qiong,ZHANG Qian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  24-27 . 
    Abstract ( 2035 )   PDF (222KB) ( 1620 )   Save
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    Objective: To study the influence of firecrackers′ impulse noise on auditory function of normal growth children in a plateau area. Methods: Seventyone and 50 children were selected from the Qinling mountain area and the pasturing area around Qinghai Lake respectively. All of them were normal growth children (6 to 12 years old) who had experienced firecrackers′ noise over 3 times per year. In addition, 50 children from Nanjing city were included in this study. The entire frequency auditory threshold was examined on the spot. The auditory threshold was analyzed. Results: There was not a significant difference in high frequency and super high frequency between the pasturing area and the Qinling mountain areas, while the girls′ auditory function was same from all places. In contrast, the auditory thresholds in high frequency and super high frequency of the boys in Nanjing city was lower than those of the boys in both mountain area and plateau pasturing area. Conclusions: According to the auditory function of girls from all places, the hypoxia area of a plateau does not have any influences on children′s hearing development, and it also does not aggravate the auditory impact of the impulse noise of firecrackers on children.
    Expression of CDK4 and P16 in human middle ear cholesteatoma
    WU Rui-shan,HUANG Fang,YANG Jin-song
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  28-31 . 
    Abstract ( 1583 )   PDF (302KB) ( 1463 )   Save
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    Objective: To observe the expression of cyclindependent kinase4(CDK4) and cyclindependent kinase inhibitor P16 in human middle ear cholesteatoma and to explore their roles in the development of cholesteatoma. Methods: Thirtyfive cholesteatomas tissues and twenty normal human external ear canal skin were used in this study. All specimens were stained by an immunohistochemical SABC method to detect the expression of CDK4 and P16. Correlations between the above indexes and between the above indexes and the degree of ossicular destruction were investigated. Result: CDK4 and P16 were expressed in parabasal layers and the upper layer, mainly in the prickle and granular layers of cholesteatoma epithelium. Their positive rates were 68.6% and 88.6%, respectively. Statistical analysis showed that there was a significant difference in positive rates between the normal external ear canal epithelium and the cholesteatoma epithelium(P=0.011, P=0.02), and a positive correlation between CDK4 and P16 in the cholesteatoma group(P<0.05). The statistical results indicated that the expression of CDK4 and P16 did not related to the extent of ossicular damage in cholesteatoma(P>0.05). Conclusion: CDK4 and P16 are overexpressed in human middle ear cholesteatoma epithelium and positively correlate with each other, suggesting that they play a cooperative role in the development of cholesteatoma. The cholesteatoma epithelium has a hyperproliferation ability and a mechanism of inhibiting the proliferation. The result of immunohistochemical examination is not related to the degree of ossicular destruction.
    Surgical treatment for the secret tympanitis at an early stage
    WANG Lin-gu,DUAN Xin-hu,LI Lan-ni,GAOXia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  32-33 . 
    Abstract ( 2071 )   PDF (204KB) ( 1737 )   Save
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    Objective: To investigate the classification of secret tympanitis and surgical treatment at an early stage. Method: The clinical data of 19 cases of secret tympanitis were reviewed. Results: By surgery, the lesions were removed and ventilation of the middle ear was improved. During a followup of 6 months to 3 years, no one relapsed. Conclusion: No matter whether there is a tympanic membrane perforation or not, secret tympanitis should be subjected to surgical treatment at an early stage.
    Injury of the eustachian tube and middle ear by sinusitis in children
    JIANG Ke-liang,WANG Jing,CHAI Mao-wen,NIU Shan-li,ZHAO Xun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  34-37 . 
    Abstract ( 2077 )   PDF (250KB) ( 1978 )   Save
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    Objective: To investigate injury of the eustachian tube and middle ear by sinusitis in children and observe the recovery of the acoustic dysfunction after treatment for sinusitis. Methods: Examination of the ear, observation of the pharyngeal ostium of the eustachian tube, acoustic impedance tests, and pure tone audiometry were performed on 100 children with chronic sinusitis and 50 normal children. Of them, in 128 ears of 68 children sinusitis was found combined with ear diseases and then treated. Results: In children with sinusitis, the abnormal rate of the eardrum, the pharyngeal ostium of the eustachian tube , the function of the eustachian tube and the acoustic impedance tests was 64%, 62%, 63.5%, and 62.5%,respectively, and the rate of hearing loss was 47.5%. Compared with the normal children, the differences were statistically significant(P<0.01). The differences of the incidence of middle ear disease and acute sinusitis, subacute sinusitis and chronic sinusitis were statistically significant between the two groups (P<0.05). The acoustic dysfunction had a significant improvement after the treatment for sinusitis. Conclusion: The changes of the eustachian tube function caused by sinusitis lead to a significantly high incidence of middle ear disease.
    Some experience of the endoscopy treatment of maxillary sinus lesion with the canine tooth fossa approach
    ZHANG Qing-quan,LI Xin-min,WANG Qiang,WANG Yong-fu
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  38-39 . 
    Abstract ( 1967 )   PDF (232KB) ( 1553 )   Save
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    Objective: Operation in the maxillary sinus tends to injure the debouchement of the nasolacrimal canal in the inferior nasal meatus and the walls of the fossa orbitalis. We tried to find a program with the least injury, duration and that was the most convenience. Methods: From March 2002 to the present, we designed an upright cut of 1 to 1.5 cm in the side labiogingival groove of the ill side above the canine tooth, separated to the bone in canine fossa, drilled a hole of 1 cm with an osteotome or electrodrill, removed the local mucosa, inserted an endoscope, and inspected the lesions inside. If submucous cysts were found, the capsule wall was removed and proper hemostasis was performed; if the mucosa was normal, there was no need to enlarge the aperture, an absorbable hemostatic gauze was laid in the wound surface and the hole, and sutured with 2 stitches; or adhered with biological glue. In patients with an antral polyp, the management was the same as the cases with sumucosa cyst. In patients with aspergillosis, we enlarged the apertures to 1-1.5cm, did not pack the nasal cavity, if we enlarged the apertures, we may pack expansive sponge. The face was oppressed with a four head belt, the plug was taken out after 48 or 72 hours according to the pathogenetic condition, and stitches were taken out after 4 or 5 days. Results: Primary healing was found in all 36 cases, with an unobstructed nasal cavity and disappearance of the symptom. No relapse was found in the period of four months to four years of followup; only 2 cases complained about transient numbness in the upper lips. All patients recovered after 7-8 days. Granulations were found in the enlarged aperture in 2 cases, and they disappeared after treatment. Conclusion: The feature of the operation is the small upright cut in the labiogingival grooves, small windowing in canine fossa, and delicate operation in the sinus cavity with a clear visual field. Lesions may be treated conveniently, which lead to less complications and less severe reactions. The maxillary sinus drains naturally, accords to the normal physiological functions and also problems are avoided that happen in other approaches.
    Endoscopic treament of refractory nasal bleeding
    HUANG Ming-zhen,ZHANG Li-qiang,CAO Jian-hua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  40-42 . 
    Abstract ( 2000 )   PDF (226KB) ( 1597 )   Save
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    Objective: To explore the effects of endoscopic treatment for refractory nasal bleeding. Methods: Twentyeight cases of refractory nasal bleeding were treated by nasal endoscopy combined with electrocoagulation and stuffing of resorbed materials. Results: Twentysix cases were cured by one treatment, one was cured by two treatments, and one was cured by conservative treatment. Conclusion: The regions of the olfactory cleft and posterior part of the inferior meatus are the common areas in cases of refractory nasal bleeding. Bleeding points can be precisely searched by nasal endoscopy. Endoscopic treatment for refractory nasal bleeding is a microinvasive and effective method.
    Postoperative followup of chronic rhinosinusitis: a comparative observation
    YAN Yong-yi,XIE Jia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  43-45 . 
    Abstract ( 1950 )   PDF (226KB) ( 1502 )   Save
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    Objective: To evaluate the total response of postoperative endoscopic checkup in chronic rhinosinustitis. Method: The response rates of two groups with chronic rhinosinusitis after the same endoscopic sinus surgery were compared and analyzed according to different followup methods. Results: In group A, 31 cases were cured, 24 were improved and 1 had no response during a sixmonth followup; 44 cases were cured and 42 had a response during a twelvemonth followup. In group B, 14 cases were cured, 43 were improved and 10 had no response during a sixmonth followup; 24 were cured, 42 were improved and 1 had no response during a twelvemonth followup. The response rate between group A and B was of significant difference (χ2=18.387, P<0.05). Conclusion: Postoperative endoscopic checkup is the most important factor for increasing the total response of endoscopic sinus surgery for chronic rhinosinusitis.
    Long-term effect on auditory brain stem function of patients with nasopharyngeal carcinoma after radiotherapy
    WU Xiang-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  46-47 . 
    Abstract ( 1723 )   PDF (236KB) ( 1665 )   Save
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    Objective: To investigate the longterm effect of radiotherapy on auditory brain stem function of patients with nasopharyngeal carcinoma(NPC). Methods: The auditory brain stem response(ABR) was examined in 33 patients (66 ears) with NPC before and at the first day, and on 3, 6, 12, 24 and 36 months after radiotherapy. Results: There were no obvious harmon auditory functions at the first day after radiotherapy. The auditory function decreased significantly at 6 months after radiotherapy and slightly recovered in the next 6 months, but after that it slightly decreased again. Conclusions: Conventional radiotherapy harms the auditory function in the longterm after treatment, so effective means should be adopted as early as possible.
    Transnasal endoscopic submucous inferior turbinate resection in treatment of chronic hypertrophic rhinitis
    LIU Jun,YU Shao-qing,FAN Yong-jiu,GUO Jun-guang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  48-50 . 
    Abstract ( 1962 )   PDF (249KB) ( 1653 )   Save
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    Objective: To sum up the experience of submucous inferior turbinate resection by transnasal endoscopy for treatment of chronic hypertrophic rhinitis(HR). Methods: Twentyfive cases of HR were treated by transnasal endoscopic submucous inferior turbinate resection with the XPS3000 surgery synthetic dynamic system and specialpurpose tool bit(group A) and 22 cases were treated with the traditional partial inferior turbinectomy(group B). The amount of hemorrhage, time of surgery, nasal ventilation and mucosa recovery of the two groups were compared. Results: The amount of hemorrhage, time of surgery, nasal ventilation and mucosa recovery of group A were significantly lower and shorter than those of group B (P<0.05). Followed up over three months, the response rates of group A and B were 92% and 86% respectively. Conclusion: Transnasal endoscopic submucous inferior turbinate resection is superior to traditional partial inferior turbinectomy in trauma and response for HR.
    Treatment of allergic rhinitis by nebulized interferon gamma
    LI Qin,DU Ying-hua,CHEN Yan-lin,LIU Yu-gang,ZHANG Da-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  51-53 . 
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    Objective: To investigate the efficacy and mechanism of nebulized interferon gamma (IFN-r) in the prevention and treatment of allergic rhinitis. Methods: Ovalbumirl (OVA) absorbed to aluminum hydroxide was used to construct the allergic rhinitis model (group C), and nebulized IFN-r 12ug was inhaled once daily on day 23 to day 30. The nasal lavage fluid was collected on day 31, and the cellular constituents, levels of IL-4, IL-5 and IgE were determined. The normal control group (group A), the allergic rhinitic model group (group B) and beclomethasone dipropionate group (group D) consisted of five mice each. Results: Decrease of eosinophils (0.005±0.003)×104/ml was seen in nasal lavage fluid of group C as compared with group B[(0.223±0.068)×104/ml,(P<0.01)], and the levels of IL-4(7.8±3.2pg/mL) and IL-5(12.5±4.6pg/mL) decreased significantly in comparison with group B(P<0.01). The serum levels of total IgE (38.5±9.6ug/ml) and ovalbuminspecific IgE(19.6±5.2U/mL )decreased significantly in comparison with those of group B(P<0.01). Conclusion: IFN-r can inhibit the composition of IL-4 and IL-5, and inhibit the airway inflammation with eosinophilic infiltration and the serum levels of total IgE and ovalbumin specific IgE, and so it is helpful in prevention and treatment of allergic rhinitis.
    A multi-factorial analysis of the factors affecting the therapeutic effect of endoscopic treatment for chronic sinusitis and nasal polyp
    LOU Zheng-cai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  54-55 . 
    Abstract ( 1854 )   PDF (236KB) ( 1949 )   Save
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    Objective: To improve the therapeutic effect of endoscopic treatment for chronic sinusitis and nasal polyp. Method: Thirtyseven patients with headache and nasal obstruction after endoscopic treatment received a followup checkup. Results: Of them, 32 cases were found with a medical ailment, 20 with residual or recurrence of pathological changes, and 5 depressive disorder. After the patients received expectant or operative treatment, all their symptoms had vanished or improved. Conclusion: Patients should be checked in an allround way before operation.
    Modified nasal septum modification
    ZHAO Shen-lin,DUAN Li-hua,SONG Dao-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  56-57 . 
    Abstract ( 1884 )   PDF (206KB) ( 2225 )   Save
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    Objective: To evaluate the clinical outcome of modified nasal septum modification for nasal septum deviation. Methods: One hundred and twentysix patients with nasal septum deviation were treated in our hospital. In the operation, the original structure was saved, the deviated nasal septum was modified by resection or fracture, and the hypertrophic inferior turbinate was moved outside by fracture. Results: Nasal septum deviation was successfully corrected with satisfactory ventilation in both sides of the nasal cavity; no perforation or flop of nasal septum occurred in any case. Conclusion: The modified nasal septum modification is safe for teenagers and is an effective method with the advantage of easy manipulation.
    A study fungal distribution in the nasal cavity of patients with nasal polyps and control
    LIU Sheng-lin,QIN Zuo-rong,DENG Quan-jiang,Guo Jian,MAO Cheng-shen
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  58-59 . 
    Abstract ( 2180 )   PDF (187KB) ( 1482 )   Save
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    Objective: To study fungal distribution in the nasal cavity of patients with nasal polyps and control. Methods: Seventy patients with chronic sinusitis and nasal polyps were enrolled in the experimental group, and fifty volunteers were enrolled in the control group. Secretions on the surface of nasal polyps were collected under sterile condition and examined under a microscope. The secretion on the surface of the middle turbinate and from the middle meatus was collected in sterilization and examined by the microscope. Results: (1) The percentage of positive fungal cultures was 51.0% and 37.7% in the experimental group and the control group, respectively. The percentage of positive fungal by examination under a microscope was 41.4% and 34% in the experimental group and the control group, respectively. (2) The percentage of positive Aspergillus species was 67.4% in the positive fungal cultures or by examination under a microscope in the experimental group and the control group. Conclusion: (1) The percentage of positive fungal by examination under a microscope and fungal cultures is similar between the experimental group and control group in the Qingdao area; (2) Aspergillus species are the major specimens in the positive fungal cultures and by examination under a microscope.
    Recovery of the maxillary sinus mucosa after FESS
    LIU Ying,ZHAO Chun-li,ZHENG Gui-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  60-61 . 
    Abstract ( 2602 )   PDF (234KB) ( 1734 )   Save
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    Objective: To investigate the recovery process of the maxillary mucosa after functional endoscopic sinus surgery (FESS) and provide information for the treatment after FESS. Methods: Sixtyeight cases were randomly divided into 2 groups: Miconazole was irrigated into the experimental group (36 cases) and normal saline (NS) was irrigated into the control group (32 cases). Results: In the experimental group, the mean cleaning time was 1.58 weeks, the mean epithelization time was 5.20 weeks, and new affections were found in 15 cases. In the NS group, the mean cleaning time was 1.63 weeks, the mean epithelization time was 5.63 weeks, and new affections were found in 16 cases. There were no differences between the two groups(P>0.05). Conclusion: The cavities should be treated for 6 weeks at least and not be irrigated with drugs.
    Non-invasive nasal sinus mycoses:a clinical analysis of 42 cases
    LI Xiao-hong,KANG Hong-jian,SHI Cui-ling
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  62-64 . 
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    Objective: To explore the clinical features,diagnosis and treatment of noninvasive nasal sinus mycoses. Methods: Fortytwo cases of nasal sinus mycoses were retrospectively analyzed. All had undergone an endoscopic operation. Results: After the operations, all cases got a regular check up with an endoscope. Thirtyeight cases quickly recovered. The other four had cheeselike matter in their maxillary sinus in the initial stage. The wound was washed several times with 1% H2O2 and 0.9% NaCl solution after the operation, and after that, the surgical cavity became clear. Forty cases were followed up for 6 months to 5 years and no recurrence occurred. The other two were not followed up. Conclusion: With endoscopic sinus surgery, surgeons can get better illumination and as many as possible functions of the nasal cavity and sinus can be preserved.
    Significance of CT imaging for anterior ethmoid sinus variations
    SUN Jian,JU Jian-bao,ZHANG Nian-kai,LI Na,FENG Wei-hua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  65-67 . 
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    Objective: To explore anatomical variations of the anterior ethmoid sinus in Chinese people and to provide reference for clinical management. Method: The clinical data of nasal sinus imaging of 263 patients were retrospectively analyzed. Result: There were statistical differences between the adult group and the pediatric group in ethmoid bulla hypertrophy and middle nasal concha etherealization. Conclusion: CT scanning is helpful in detecting anatomical variations interrelated with risk of sinonasal surgery.
    Differentially expressed genes in laryngeal squamous cell carcinoma and normal tissue by cDNA microarray
    LIU Rui,SHI Wen-jie,LIU Ji-xiang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  68-70 . 
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    Objective: To screen for the differentially expressed genes in laryngeal squamous carcinoma cells and normal laryngeal tissues using cDNA microarray. Methods: The samples from two laryngeal squamous carcinoma tissues were tested using DNA microarrays. The DNAs were fixed on a glass plate by a series of treatments. The mixed probes were then hybridized to DNA microarrays and scanned for fluorescent signals. Differences between the two tissues were produced. Results: Ran belonging to Ras gene family increased 12.207 times, RAB32 belonging to Ras gene family increased 4.904 times and BIRC5 (Survivin) increased 15.495 times. They were significantly highly expressed in laryngeal cancer. The GFI1B gene decreased 0.0265 times. The GATA1 gene was significantly lowly expressed in one laryngeal cancer and was not expressed in carcinoma cells of another patient. Conclusion: cDNA microarray made in our Lab can recognize more than 7000 gene differences between cancer tissues and normal tissues at the same time and find gene variation. These results accord with other studys.
    Trachobronchial foreign bodies in adult patients: a retrospective analysis
    LIU He,ZHANG Li-qiang,HE Hai-xian,SUN Rui-jie,XU Hao-jie,WANG Xue-hai,CHEN Cheng-fang,ZHANG Hai-yan,LI Xue-zhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  71-73 . 
    Abstract ( 2282 )   PDF (262KB) ( 2002 )   Save
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    Objective: To investigate the clinical characteristics and experiences of trachobronchial foreign bodies in adult patients. Methods: The clinical data of 30 cases admitted between October 1996 and May 2006 were retrospectively analyzed. The foreign bodies were varied and mainly were dentures and plants. Results: In one case the foreign body was taken out by direct laryngoscopy, three cases were subjected to emergency tracheotomies, four cases were subjected to rigid bronchoscopies and tracheotomies and the other 22 cases were subjected to rigid bronchoscopies. Conclusion: Trachobronchial foreign bodies are able to be successfully taken out based on their kinds and positions.
    Effects of adenoidectomy for severe sescretory otitis media in children
    YU Li,HAN Xiao-pan,LI Xiao-yan,ZHAO Qiu-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  74-75 . 
    Abstract ( 2306 )   PDF (214KB) ( 1567 )   Save
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    Objective: To explore the effects of adenoidectomy for severe secretory otitis media. Methods: Audition, acoustic impedance and pure tone audiometer were measured in 32 cases after adenoidectomy. Results: Twentyeight cases were cured, three cases had some responses, and one case had no response. The response rate was 96.9%. Conclusion: Adenoidectomy is one of the efficient means for pediatric severe secretory otitis media.
    Anesthesia both in an adenoidectomy and in a tonsillectomy for epileptic children
    YAN Jun-xin,WANG Guo-yi,ZHANG Xiu-ying
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  76-77 . 
    Abstract ( 2240 )   PDF (228KB) ( 1622 )   Save
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    Objective: To evaluate the security of anesthesia management both in adenoidectomy and in tonsillectomy for epileptic children. Method: Anesthesia was induced with midazolam, propofol, fentanyl and vecuronium by endotracheal intubation and retention with a low concentration of enflurane. Result: The response was good. Hyperspasmia did not occur during the operations. Conclusion: Combined anesthesia management is more responsible and safe for epileptic children both in an adenoidectomy and in a tonsillectomy.
    Effect of phacoemulsification combined with intraocular lens implantation in diabetic patients with cataract
    WANG Zheng-yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(1):  78-80 . 
    Abstract ( 1838 )   PDF (247KB) ( 1710 )   Save
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    Objective: To investigate the clinical results of phacoemulsification combined with intraocular lens implantation in diabetics with cataract. Methods: A clinical comparative observation of phacoemulsification combined with intraocular lens implantation was performed on 55 eyes of 50 diabetic patients and 55 of 50 with senile cataract. Postoperative complications and visual acuity were observed. Results: There were no obvious differences of complications and postoperative visual acuity between the two groups. Conclusion: Phacoemulsification combined with intraocular lens implantation in diabetics whose blood sugar is well controlled is safe and effective.