Table of Content

24 December 2006 Volume 20 Issue 6

  

Articles

Functional endoscopic sinus surgery, FESS

LIN Bin,WANGHui-ge

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2006, 20(6):  481-487 . 

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Expression of EGFR, cMet and HER2/neu in chordoma and other cancers

Paul Weinberger,Clarence Sasaki

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2006, 20(6):  488-492 . 

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To investigate the expression of cMet, cErbb2 and EGFR in 12 chordomas, based on the current and future availability of targeted molecular inhibitors. Method: Protein expression levels were analyzed by immunohistochemical analysis from 12 chordomas and 51 other tumors from 17 assorted solid tissue tumor types using multitumored tissue microarray. Results: Most chordomas displayed strong expression of EGFR and cMet, while a variable level of expression of HER2/neu was observed. In addition, we noted a strong correlation between EGFR and cMet expression, especially for primary chordomas (P=0.006). Conclusions: Chordoma, like many other solidtissue tumors, expresses HER2/neu, EGFR and cMet. Most chordoma has strong expression of both cMet and EGFR. Inhibitors to EGFR are already in clinical use for other solid tissue tumors and represent a potentially viable experimental treatment option for refractory chordoma.

Innervation of the rat endolymphatic sac

TAN Jie,ZHANG Rong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2006, 20(6):  493-496 . 

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The endolymphatic sac (ES) is a part of the homeostasisregulating system of the membranous labyrinth of the inner ear. Factors that influence blood flow in the sac may affect its function. This blood flow may be influenced by autonomic innervation; however，no such innervation has been demonstrated. The purpose of this study is to confirm the existence of the nerve fibres on the endolymphatic sac. Methods: Fifteen healthy Swards white rats were divided into three groups randomly. The temporal bones were taken out and were processed and sectioned by paraffinembedded technique. The sections of ES were stained by the antibody that was not labeled by biotin including the antibody for neurone specific enolase (NSE), antibody for glial fibrillary acidic protein (GFAP) and antibody for neurofilament (NF). The slides were observed by light microscope. Results： On light microscope, the brown positive staining was observed in the epithelia of ES. However，there was not any positive staining on the negative control slides. Conclusion: Nerve fibers exactly exist in the epithelia of ES.

Influencing factors on the health related quality of life of patientwith obstructive sleep apnea hypopnea syndrome

WU Ji-yong,XU Heng-guang

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2006, 20(6):  536-538 . 

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To assess the association of healthrelated quality of life(HRQoL) with the polysommographic parameters and the excessive daytime sleepiness(EDS). Methods： Ninetysix patients with OSAHS were assessed the HRQoL by using the SF36 and the EDS by using the Epworth sleepiness scale(ESS). The association between each domain on SF36, the polysommographic parameters and ESS score were examined by Person linear correlation. Results： ESS scores positively correlated with the arousal index and AHI and negatively with the lowest arterial oxygen.The factors significantly correlated with AHI were the physical functioning and the general health subscales of the SF36. Only the body pain significantly correlated with the mean lowest SaO2. Among the SF36 subscales, the physical functioning and the role of physical subscale correlated with the arousal index. Conclusions： Several subjective complaints and subscales of the SF36 correlate significantly with a frequency of SDBrelated arousal. Patients perceive that their quality of life has been impaired more by an organic health problem than by an emotional problem.