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28 March 2019 Volume 32 Issue 2

  

Progress of research on autophagy, inner ear development, and auditory function

XU Ang, LIU Tingyan, HAN Fengchan

Journal of Otolaryngology and Ophthalmology of Shandong University. 2019, 32(2):  123-125.  doi:10.6040/j.issn.1673-3770.0.2018.398

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Presbycusis, also known as age-related hearing loss(AHL), is characterized by high-frequency hearing loss. With the aging of the society, AHL-related morbidity is increasing. Autophagy plays a pivotal role in central nervous system senescence and neurodegeneration. Autophagy can transfer toxic molecules and organelles to lysosomes, a process vital to the health and survival of neurons. The development of the inner ear is regulated by autophagy and plays an important role in maintaining the morphology and function of auditory hair cells.