JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (4): 43-46.doi: 10.6040/j.issn.1673-3770.0.2017.189

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Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps.

ZHI Lili1, SONG Daoliang2   

  1. 1. Allergic Clinic of Department of Otolaryngology, North Branch of Zibo Central Hospital;2. Department of Otolaryngology, Zibo Central Hospital, Zibo 255031, Shandong, China
  • Received:2017-05-02 Online:2017-08-16 Published:2017-08-16

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Abstract: Objective To compare eosinophil infiltration as well as the IL5 mRNA levels in antrochoanal polyps(ACP), nasal polyps with allergic rhinitis(NPwAR), and nasal polyps without allergic rhinitis(NPsAR). Methods A total of 10 patients with ACP, 9 with NPwAR, and 13 with NPsAR were enrolled in this study. Eosinophil infiltration was analyzed by hematoxylin and eosin staining. The level of IL5 mRNA was determined by quantitative PCR. Results Eosinophil infiltration in ACP was significantly less than that in NPwAR(P<0.001). Although the median eosinophil infiltration in ACP was less than that in NPsAR, the difference was not statistically significant. Eosinophil infiltration in NPsAR was significantly less than that in NPwAR(P< 0.05). The IL5 mRNA level in ACP was significantly lower than those in NPsAR(P<0.05)and NPwAR(P=0.001). In addition, the IL5 mRNA level in NPsAR was significantly lower than that in NPwAR(P<0.05). Conclusion Antrochoanal polyps may differ in their pathogenesis from NP. Eosinophils and IL5 both play a role in the etiology of NP with or without AR, but may not play important roles in the pathogenesis of ACP.

Key words: Nasal polyps, Allergic rhinitis, Eosinophils, Interleukin-5, Antrochoanal polyps

CLC Number: 

  • R765.2
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