Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (1): 48-54.doi: 10.6040/j.issn.1673-3770.0.2021.260

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Hearing loss in children after bacterial meningitis: a systematic review and meta-analysis

LIU Shanshan1, HAN Shujing2, WANG Xiaoxu1, LI Yanhong1, NI Xin1,2, ZHANG Jie1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, National Center for Children's Health China / Beijing Children's Hospital, Capital Medical University, Beijing 100045, China;
    2. National Center for Children's Health China / Beijing Children's Hospital, Capital Medical University / Beijing Pediatric Research Institute / Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head & Neck Surgery, Beijing 100045, China
  • Published:2022-02-22

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Abstract: Objective To systematically evaluate the risk factors for hearing loss after bacterial meningitis in children. Methods Electronic databases including PubMed, EMbase, Web of Science, CNKI, Sinomed, Wanfang data, and VIP were searched from inception to September 20, 2021 to gather studies published on hearing loss in children after bacterial meningitis. Two authors independently assessed the quality of the studies using the NOS Scale, and a meta-analysis was performed using Stata 16.0 software. Results Twelve studies(3 cohort and 9 case-control studies)measured hearing in a total of 2041 children with bacterial meningitis among whom 301 children suffered sensorineural hearing loss. Meta-analysis was performed for a total of 4 risk factors. Results showed that Streptococcus pneumoniae infection ［OR=2.70, 95%CI(1.89, 3.87), P<0.001］ and seizures ［OR=2.31, 95%CI(1.29, 4.14), P=0.005］ were risk factors for hearing loss after bacterial meningitis; age ≤ 1 year old ［OR=1.00, 95%CI(0.34, 2.97), P=0.998］ and sex ［OR=1.06, 95%CI(0.70, 1.58), P=0.794］ were not associated with hearing loss. Conclusion Current evidence shows that Streptococcus pneumoniae infection and seizures are risk factors for hearing loss after bacterial meningitis. For children with the above risk factors, special attention should be paid to their hearing, and follow-up should be strengthened.

Key words: Children, Bacterial meningitis, Hearing, Risk factors, Meta-analysis

CLC Number: 

  • R764.43+1
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