Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (3): 110-114.doi: 10.6040/j.issn.1673-3770.0.2025.250

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Multiple mechanisms and clinical warning signs of deafness caused by hepatitis B virus

WANG Menghui, LI Ao, WEI Hao, JIANG Yue, WU Xingguang, LI Luxi, QIAN Xiaoyun   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated of Medical School, Nanjing University/Institute of Otorhinolaryngology, Nanjing Drum Tower Hospital, Nanjing 210008, Jiangsu, China
  • Published:2026-05-22

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Abstract: Hepatitis B virus infection is a global public health concern. The impact of the virus is not limited to the liver, but can affect other systems too. However, the mechanisms and clinical features of auditory system damage have not been systematically clarified. Through evidence-based integration, this study found that the incidence of sensorineural hearing loss in patients with chronic hepatitis B is significantly higher than that in hepatitis B virus carriers, and potential mechanisms were revealed. Meanwhile, it is proposed that sudden sensorineural hearing loss may be a warning sign of acute exacerbation of chronic hepatitis B. This study provides an evidence-based basis for audiological monitoring of HBV-infected individuals. It is recommended that audiological assessment should be included in the management pathway for hepatitis B-infected individuals, and the development of ear-protective antiviral drugs should be promoted.

Key words: Hepatitis B virus, Sensorineural hearing loss, Drug ototoxicity, Immunoreaction

CLC Number: 

  • R512.6+2
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