ISSN 1673-3770 CN 37-1437/R
Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (2): 151-158.doi: 10.6040/j.issn.1673-3770.0.2021.536
• 综述 • Previous Articles
LI Mengting, HE Shuxi, WANG Hua
CLC Number:
| [1] Shetty R, D'Souza S, Khamar P, et al. Biochemical markers and alterations in keratoconus[J]. Asia Pac J Ophthalmol(hpila), 2020, 9(6): 533-540. doi:10.1097/apo.0000000000000332 [2] Saghizadeh M, Chwa M, Aoki A, et al. Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas[J]. Exp Eye Res, 2001, 73(2): 179-189. doi:10.1006/exer.2001.1028 [3] Lema I, Durán JA, Ruiz C, et al. Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects[J]. Cornea, 2008, 27(7): 758-763. doi:10.1097/ICO.0b013e31816a3591 [4] Balasubramanian SA, Mohan S, Pye DC, et al. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus[J]. Acta Ophthalmol, 2012, 90(4): e303-e309. doi:10.1111/j.1755-3768.2011.02369.x [5] Kolozsvári BL, Berta A, Petrovski G, et al. Alterations of tear mediators in patients with keratoconus after corneal crosslinking associate with corneal changes[J]. PLoS One, 2013, 8(10): e76333. doi:10.1371/journal.pone.0076333 [6] Yabuta C, Yano F, Fujii A, et al. Galectin-3 enhances epithelial cell adhesion and wound healing in rat cornea[J]. Ophthalmic Res, 2014, 51(2): 96-103. doi:10.1159/000355846 [7] McMonnies CW. Inflammation and keratoconus[J]. Optom Vis Sci, 2015, 92(2): e35-e41. doi:10.1097/opx.0000000000000455 [8] Wilson SE, He YG, Weng J, et al. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing[J]. Exp Eye Res, 1996, 62(4): 325-327. doi:10.1006/exer.1996.0038 [9] Balasubramanian SA, Pye DC, Willcox MD. Are proteinases the reason for keratoconus? [J]. Curr Eye Res, 2010, 35(3): 185-191. doi:10.3109/02713680903477824 [10] Abu-Amero KK, Azad TA, Kalantan H, et al. Mitochondrial sequence changes in keratoconus patients[J]. Invest Ophthalmol Vis Sci, 2014, 55(3): 1706-1710. doi:10.1167/iovs.14-13938 [11] Nabil KM, Elhady GM, Morsy H. The association between interleukin 1 beta promoter polymorphisms and keratoconus incidence and severity in an Egyptian population[J]. Clin Ophthalmol, 2019, 13: 2217-2223. doi:10.2147/OPTH.S220723 [12] Balasubramanian SA, Pye DC, Willcox MDP. Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus[J]. Clin Exp Optom, 2013, 96(2): 214-218. doi:10.1111/cxo.12038 [13] Ebihara N, Matsuda A, Nakamura S, et al. Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing[J]. Invest Ophthalmol Vis Sci, 2011, 52(12): 8549-8557. doi:10.1167/iovs.11-7956 [14] Jones SA, Horiuchi S, Topley N, et al. The soluble interleukin 6 receptor: mechanisms of production and implications in disease[J]. FASEB J, 2001, 15(1): 43-58. doi:10.1096/fj.99-1003rev [15] Huovila APJ, Turner AJ, Pelto-Huikko M, et al. Shedding light on ADAM metalloproteinases[J]. Trends Biochem Sci, 2005, 30(7): 413-422. doi:10.1016/j.tibs.2005.05.006 [16] Izumi-Nagai K, Nagai N, Ozawa Y, et al. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3(STAT3)promotes choroidal neovascularization[J]. Am J Pathol, 2007, 170(6): 2149-2158. doi:10.2353/ajpath.2007.061018 [17] Abraham LJ, Kroeger KM. Impact of the-308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease[J]. J Leukoc Biol, 1999, 66(4): 562-566. doi:10.1002/jlb.66.4.562 [18] Arbab M, Tahir S, Niazi MK, et al. TNF-α genetic predisposition and higher expression of inflammatory pathway components in keratoconus[J]. Invest Ophthalmol Vis Sci, 2017, 58(9): 3481-3487. doi:10.1167/iovs.16-21400 [19] Beyaert R, Fiers W. Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not[J]. FEBS Lett, 1994, 340(1/2): 9-16. doi:10.1016/0014-5793(94)80163-0 [20] Shetty R, Ghosh A, Lim RR, et al. Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A[J]. Invest Ophthalmol Vis Sci, 2015, 56(2): 738-750. doi:10.1167/iovs.14-14831 [21] Amento EP, Beck LS. TGF-beta and wound healing[J]. Ciba Found Symp, 1991, 157:115-123. doi:10.1002/9780470514061.ch8 [22] Saika S. TGF-β pathobiology in the eye[J]. Laboratory investigation, 2006, 86(2):106-115. doi: 10.1038/labinvest.3700375 [23] Sanford LP, Ormsby I, Gittenberger-de Groot AC, et al. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes[J]. Development, 1997, 124(13): 2659-2670. doi:10.1242/dev.124.13.2659 [24] Priyadarsini S, McKay TB, Sarker-Nag A, et al. Keratoconus in vitro and the key players of the TGF-β pathway[J]. Mol Vis, 2015, 21: 577-588 [25] Engler C, Chakravarti S, Doyle J, et al. Transforming growth factor-β signaling pathway activation in Keratoconus[J]. Am J Ophthalmol, 2011, 151(5): 752-759.e2. doi:10.1016/j.ajo.2010.11.008 [26] Al Qattan A, Lessard L, Philip A, et al. Abstract 84: nAG(a salamander-derived protein)as an inhibitor of TGF-β signaling and fibrotic responses. PSRC 2018 Abstract supplement, 2018: 67-68. doi: 10.1097/01.GOX.0000533949.54354.9b [27] Lyon D', McKay TB, Sarkar-Nag A, et al. Human keratoconus cell contractility is mediated by transforming growth factor-beta isoforms[J]. J Funct Biomater, 2015, 6(2): 422-438. doi:10.3390/jfb6020422 [28] Yang YN, Wang F, Zhou W, et al. TNF-α stimulates MMP-2 and MMP-9 activities in human corneal epithelial cells via the activation of FAK/ERK signaling[J]. Ophthalmic Res, 2012, 48(4): 165-170. doi:10.1159/000338819 [29] Aren A, Gökçe AH, Gökçe FS, et al. Roles of matrix metalloproteinases in the etiology of inguinal hernia[J]. Hernia, 2011, 15(6): 667-671. doi:10.1007/s10029-011-0846-5 [30] Nagase H, Woessner JF Jr. Matrix metalloproteinases[J]. J Biol Chem, 1999, 274(31): 21491-21494. doi:10.1074/jbc.274.31.21491 [31] Fini ME, Cook JR, Mohan R. Proteolytic mechanisms in corneal ulceration and repair[J]. Arch Dermatol Res, 1998, 290: S12-S23. doi:10.1007/pl00007449 [32] Du G, Liu C, Li X, et al. Induction of matrix metalloproteinase-1 by tumor necrosis factor-α is mediated by interleukin-6 in cultured fibroblasts of keratoconus[J]. Exp Biol(Med Maywood), 2016, 241(18): 2033-2041. doi:10.1177/1535370216650940 [33] Librach CL, Feigenbaum SL, Bass KE, et al. Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro[J]. J Biol Chem, 1994, 269(25): 17125-17131. doi:10.1016/S0021-9258(17)32529-2 [34] Vettraino IM, Roby J, Tolley T, et al. Collagenase-I, stromelysin-I, and matrilysin are expressed within the placenta during multiple stages of human pregnancy[J]. Placenta, 1996, 17(8): 557-563. doi:10.1016/s0143-4004(96)80072-5 [35] Li DQ, Lokeshwar BL, Solomon A, et al. Regulation of MMP-9 production by human corneal epithelial cells[J]. Exp Eye Res, 2001, 73(4): 449-459. doi:10.1006/exer.2001.1054 [36] Golub LM, Ramamurthy NS, McNamara TF, et al. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs[J]. Crit Rev Oral Biol Med, 1991, 2(3): 297-321. doi:10.1177/10454411910020030201 [37] Peng SX, VonBargen EC, Bornes DM, et al. Permeability of articular cartilage to matrix metalloprotease inhibitors[J]. Pharm Res, 1998, 15(9): 1414-1418. doi:10.1023/a: 1011905806123 [38] Cox SW, Eley BM, Kiili M, et al. Collagen degradation by interleukin-1beta-stimulated gingival fibroblasts is accompanied by release and activation of multiple matrix metalloproteinases and cysteine proteinases[J]. Oral Dis, 2006, 12(1): 34-40. doi:10.1111/j.1601-0825.2005.01153.x [39] di Martino E, Ali M, Inglehearn CF. Matrix metalloproteinases in keratoconus-Too much of a good thing? [J]. Exp Eye Res, 2019, 182: 137-143. doi:10.1016/j.exer.2019.03.016 [40] Smith VA, Easty DL. Matrix metalloproteinase 2: involvement in keratoconus[J]. Eur J Ophthalmol, 2000, 10(3): 215-226. doi:10.1177/112067210001000305 [41] Kenney MC, Chwa M, Opbroek AJ, et al. Increased gelatinolytic activity in keratoconus keratocyte cultures. A correlation to an altered matrix metalloproteinase-2/tissue inhibitor of metalloproteinase ratio[J]. Cornea, 1994, 13(2): 114-124. doi:10.1097/00003226-199403000-00003 [42] Stuart KA, Riordan SM, Lidder S, et al. Hepatocyte growth factor/scatter factor-induced intracellular signalling[J]. Int J Exp Pathol, 2000, 81(1): 17-30. doi:10.1046/j.1365-2613.2000.00138.x [43] Organ SL, Tsao MS. An overview of the c-MET signaling pathway[J]. Ther Adv Med Oncol, 2011, 3(1): S7-S19. doi:10.1177/1758834011422556 [44] Wilson SE, Walker JW, Chwang EL, et al. Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea[J]. Invest Ophthalmol Vis Sci, 1993, 34(8): 2544-2561. doi: 10.1007/BF00919654 [45] Wilson SE, Liang Q, Kim WJ. Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding[J]. Invest Ophthalmol Vis Sci, 1999, 40(10): 2185-2190. doi: doi:10.1097/00004397-199903940-00012 [46] Burdon KP, Macgregor S, Bykhovskaya Y, et al. Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus[J]. Invest Ophthalmol Vis Sci, 2011, 52(11): 8514-8519. doi:10.1167/iovs.11-8261 [47] Liu Y, Michalopoulos GK, Zarnegar R. Structural and functional characterization of the mouse hepatocyte growth factor gene promoter[J]. J Biol Chem, 1994, 269(6): 4152-4160. doi: 10.1016/0092-8674(94)90120-1 [48] De Benedetto A, Agnihothri R, McGirt LY, et al. Atopic dermatitis: a disease caused by innate immune defects? [J]. J Invest Dermatol, 2009, 129(1): 14-30. doi:10.1038/jid.2008.259 [49] Kallinikos P, Efron N. On the etiology of keratocyte loss during contact lens wear[J]. Invest Ophthalmol Vis Sci, 2004, 45(9): 3011-3020. doi:10.1167/iovs.04-0129 [50] Shneor E, Millodot M, Blumberg S, et al. Characteristics of 244 patients with keratoconus seen in an optometric contact lens practice[J]. Clin Exp Optom, 2013, 96(2): 219-224. doi:10.1111/cxo.12005 [51] Winkler M, Shoa G, Xie Y, et al. Three-dimensional distribution of transverse collagen fibers in the anterior human corneal stroma[J]. Invest Ophthalmol Vis Sci, 2013, 54(12): 7293-7301. doi:10.1167/iovs.13-13150 [52] Mackiewicz Z, Määtä M, Stenman M, et al. Collagenolytic proteinases in keratoconus[J]. Cornea, 2006, 25(5): 603-610. doi:10.1097/01.ico.0000208820.32614.00. [53] Fodor M, Kolozsvári BL, Petrovski G, et al. Effect of contact lens wear on the release of tear mediators in keratoconus[J]. Eye Contact Lens, 2013, 39(2): 147-152. doi:10.1097/ICL.0b013e318273b35f [54] Shoham A, Hadziahmetovic M, Dunaief JL, et al. Oxidative stress in diseases of the human cornea[J]. Free Radic Biol Med, 2008, 45(8): 1047-1055. doi:10.1016/j.freeradbiomed.2008.07.021 [55] Kenney MC, Brown DJ. The cascade hypothesis of keratoconus[J]. Contact Lens Anterior Eye, 2003, 26(3): 139-146. doi:10.1016/S1367-0484(03)00022-5 [56] Wojcik K A, Kaminska A, Blasiak J, et al. Oxidative stress in the pathogenesis of keratoconus and fuchs endothelial corneal dystrophy[J]. Int J Mol Sci, 2013, 14(9): 19294-19308. doi:10.3390/ijms140919294 [57] Gondhowiardjo TD, van Haeringen NJ, Völker-Dieben HJ, et al. Analysis of corneal aldehyde dehydrogenase patterns in pathologic corneas[J]. Cornea, 1993, 12(2): 146-154. doi:10.1097/00003226-199303000-00010 [58] Sharma N, Rao K, Maharana PK, et al. Ocular allergy and keratoconus[J]. Indian J Ophthalmol, 2013, 61(8): 407-409. doi:10.4103/0301-4738.116063 [59] Ahuja P, Dadachanji Z, Shetty R, et al. Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus[J]. Indian J Ophthalmol, 2020, 68(10): 2067-2074. doi:10.4103/ijo.IJO_1191_19 [60] 夏艳云, 钟定娟, 王华, 等. 高能量加速型角膜胶原交联术对圆锥角膜眼表的影响[J]. 山东大学耳鼻喉眼学报, 2021, 35(6): 42-51. doi: 10.6040/j.issn.1673-3770.0.2021.432 XIA Yanyun, ZHONG Dingjuan, WANG Hua, et al. Effect of high-energy accelerated corneal collagen cross-linking on the ocular surface of keratoconus[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 42-51. doi: 10.6040/j.issn.1673-3770.0.2021.432 |
| [1] | WANG Zhiyuan, HAO Zhongkai, ZHANG Chenming. The effect of local micro-pressure oxygen on the repair and oxidative stress of rabbit corneal epithelial cells after injury [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 80-86. |
| [2] | LI Kai, LUO Dan. Runmu ling formula ameliorates ocular surface damage in dry eye rats by activating the LC3-ATG5 autophagy pathway and inhibiting inflammatory factor expression [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 92-101. |
| [3] | LYU Qian, TANG Yuan, GU Zijun, SHI Sailei, LIU Ping, WAN Wenjin. Current status of benefit finding among patients with allergic rhinitis and its influence factors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 21-28. |
| [4] | GU Min, LU Meiping. Advances in the application of nanomedicine delivery systems in allergen immunotherapy for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 106-111. |
| [5] | DUAN Siyu, XUE Jinmei. Research progress of histone deacetylase 2 in glucocorticoid resistance in chronic airway inflammatory diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 120-126. |
| [6] | QIN Nana, LI Yufen, SUN Yuhao, WEI Jian, LI Qin. Effect of interleukin-13 receptor-α2 on nasal mucosal remodeling in rats with allergic rhinitis by TGF-β1/Smad signaling pathway [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 71-77. |
| [7] | DU Kangli, ZHENG Zhenyu, XU Zhanjiang, ZHANG Yu, CHEN Lu, LU Mengyao. Construction and validation of risk prediction model for nasal septal deviation complicated with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 78-86. |
| [8] | GAO Lin, HE Jinmei, YANG Mingyi. Correlation between serum levels of Sestrin2 and NADPH oxidase-2 and fundus lesions in patients with diabetes retinopathy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 113-117. |
| [9] | XIONG Qin, ZHANG Yan, WU Rina, LI Feng, TANG Lixing. Application of intranasal corticosteroids in pediatrics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 160-167. |
| [10] | XU Xuemeng, FAN Lei, YU Wangbo, JIANG Zhiyue, PAN Chen, HUANG Yongqin. Meta-analysis of the efficacy of omalizumab in combination with specific immunotherapy for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 26-33. |
| [11] | HUANG Huan, HUA Hongli, DENG Yuqin, JIANG Chengyang, WANG Yuwei, YANG Xinghai. Correlation of allergic rhinitis, tonsil adenoid hypertrophy, and sinusitis in children and analysis of its clinical guiding value [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 34-41. |
| [12] | LIU Yijun, GU Yue, GUAN Dayu, YANG Yucheng, SHEN Yang. The long-term clinical efficacy and safety of vidian neurectomy in refractory allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 42-48. |
| [13] | ZHANG Ting, WANG Meilan, GAO Yingqin. Research progress of IL-35 in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 139-147. |
| [14] | KE Bingbing, CHEN Ming, WANG Hongyang, LI Chunyan, YIN Shankai. CAMK4-mediated oxidative stress injury in auditory central neurons induced by bilirubin [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 1-10. |
| [15] | CHEN Ming, KE Bingbing, CUI Yaqi, WU Cuiping, CHEN Zhengnong, LI Chunyan, YIN Shankai. The antagonistic effects of NAD+ on cisplatin-induced oxidative stress injury in hair cells and the regulation of related gene expression [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 11-18. |
|
||