Abstract: Objective To investigate the clinical characteristics, diagnosis and treatment of antineutrophil cytoplasmic antibody(ANCA)associated vasculitis(AAV)complicated with scleritis and cataract. Methods Review the medical records of a 73-year-old female patient. One year after she was diagnosed as AAV in a foreign hospital, she was complicated with left eye scleritis, and the blurred vision in the left eye gradually worsened in the past six months. In our hospital, she was diagnosed as complicated cataract in the left eye, and she underwent phacoemulsification and intraocular lens implantation for cataract in the left eye. Results The corrected visual acuity was 0.3 on the first day after operation, and the anterior posterior segment was stable after 4 months of follow-up. Conclusion The clinical manifestations of AAV are complex and diverse, which is a group of rare diseases with potential vision threatening complications. The ANCA index of patients with vasculitis in the early or remission stage can be negative, and its titer will decrease when the disease is in remission, which can be used as an evaluation index to monitor the progress of the disease and judge the treatment effect. In terms of treatment, the combination of systemic drugs and early intervention of ophthalmology can reduce the degree of eye damage. The successful treatment of eye symptoms is usually based on effective systemic treatment, but sometimes the intervention of surgery is also necessary, and the selection of surgery and drug treatment are very important for the prognosis of the disease.

Key words: ANCA associated vasculitis, Anti-neutrophil cytoplasmic antibody, Scleritis, Cataract