Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (6): 145-152.doi: 10.6040/j.issn.1673-3770.0.2023.226

• Clinical Study • Previous Articles     Next Articles

A clinical investigation of the hematological parameters related to obstructive sleep apnea in Children

YUAN Chenyang1,2, FENG Chen3, WANG Yan4, LI Yanzhong4, FANG Zhensheng2   

  1. 1. Department of Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical University, Harbin 150007, Heilongjiang, China2. Department of Otorhinolaryngology, Second People's Hospital Affiliated to Shandong First Medical University, Taian 271000, Shandong, China3. Department of Otorhinolaryngology & Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China4. Department of Otorhinolaryngology, Qilu Hospital of Shandong University/National Heath Commssion Key Laboratory of Ctorhinolaryngology (Shandong University), Jinan 250012, Shandong, China
  • Published:2023-12-15

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Abstract: Objective This study investigated the differences in hematological parameters between children with and without obstructive sleep apnea(OSA), and the variations in hematological parameters among children with varying severity and clinical phenotypes of OSA. The research aimed to provide a theoretical framework for the diagnosis and precise treatment of pediatric OSA. Methods The study included 76 children diagnosed with OSA due to snoring and 37 children in the control group who visited the Otolaryngology department for consultation. Data, such as medical history, radiological examinations, physical examinations for both groups, sleep breathing monitoring results, and peripheral blood parameters including WBC, HB, ANC, ALC, PLT, MPV, PDW, RDW, NLR, and PLR, were analyzed. Results Children with OSA showed elevated hematological indices(WBC, ANC, ALC, HB, NLR, PLR, PLT, and MPV)compared to children without OSA. In particular, RDW exhibited a significant difference between the two groups(P=0.001). Subgroups of children with different OSA severity were evaluated and the results showed that the WBC, ANC, ALC, NLR, RDW, and PLT levels increased with increasing OSA severity. Moreover, WBC, ANC, and NLR were significantly different between the subgroups(P<0.001; P<0.001; P=0.017). Notably, children with significant adenoid hypertrophy displayed significantly higher WBC, ANC, and NLR levels compared to those with pathological hypertrophy, moderate hypertrophy, and the control group, with ANC and NLR showing statistical significance(P=0.014; P=0.015). Conclusion Peripheral blood inflammatory parameters can serve as essential indicators of OSA in the clinical setting. These parameters can assist clinical physicians in the examination, prediction, and evaluation of pediatric OSA and its severity OSA. Of the analyzed parameters, WBC, ANC, and NLR are readily available clinical indices, and thus, may be considered as potential predictive factors for the pediatric OSA and its severity, in addition to other systemic inflammatory levels.

Key words: Sleep apnea, Children, Inflammatory response, Hematological parameters, Complete blood count

CLC Number: 

  • R766
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