JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (3): 13-17.doi: 10.6040/j.issn.1673-3770.0.2017.216

Previous Articles     Next Articles

Clinical applicationof rush immunotherapy for allergic rhinitis.

ZHU Xinhua   

  1. Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China
  • Received:2017-05-10 Online:2017-06-16 Published:2017-06-16

PDF (PC)

957

Abstract: In rush immunotherapy for allergic rhinitis, the dosage of allergen is increased in a short time, and this can enhance the efficacy of the treatment. However, owing to concerns regarding its safety, it has been rarely clinically applied. In this paper, a literature review about the clinical application of rush immunotherapy has been conducted to explore and analyze the feasibility of this treatment.

Key words: Desensitization, immunologic, Rush immunotherapy, Allergens, Allergic rhinitis

CLC Number: 

  • R765.21
[1] Yuan Zhang, Luo Zhang. Prevalence of Allergic Rhinitis in China[J].Allergy Asthma Immunol Res, 2014, 6(2):105-113.
[2] Varshney J, Varshney H. Allergic Rhinitis: an Overview[J]. Indian J Otolaryngol Head Neck Surg, 2015, 67(2):143-149.
[3] Lisa M, Wheatley MD, M PH, et al. Allergic rhinitis[J]. N Engl J Med, 2015, 372(5): 456-463.
[4] Jutel M, Agache I, Bonini S, et al. International consensus on allergen immunotherapy II:Mechanisms,standardization,and pharmacoeconomics[J]. J Allergy Clin Immunol, 2016, 137(2):358-368.
[5] Jutel M, Agache I, Bonini S, et al. International consensus on allergy immunotherapy[J]. J Allergy Clin Immunol, 2015, 136(3):556-568.
[6] 程雷. 特异性免疫治疗是变应性鼻炎的一线疗法[J]. 山东大学耳鼻喉眼学报, 2016, 30(4):1-2. CHENG Lei. Allergen-specific immunotherapy as the first-line treatment for allergic rhinitis[J]. J Otolaryngol Ophthalmol Shandong Univ, 2016, 30(4):1-2.
[7] Jutel M, Kosowska A, Smolinska S. Allergen immunotherapy: Past, present, and future[J].Allergy Asthma Immunol Res, 2016, 8(3):191-197.
[8] Di Bona D, Plaia A, Leto-Barone MS, et al. Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: a meta-analysis-based comparison[J]. J Allergy Clin Immunol, 2012, 130(5):1097-1107.
[9] Tabar AI, Echechipía S, García BE, et al. Double-blind comparative study of cluster and conventional immunotherapy schedules with Dermatophagoidespteronyssinus[J]. J Allergy Clin Immunol, 2005, 116(1):109-118.
[10] Cox LS. Shooting for a faster approach to the immunotherapy target: will cluster become conventional?[J]. Ann Allergy Asthma Immunol, 2009, 102(3):177-178.
[11] Kim HB, Jin HS, Lee SY,et al. The Effect of Rush Immunotherapy with house dust mite in the production of IL-5 and IFN-γ from the peripheral blood T cells of asthmatic children[J]. J Korean Med Sci, 2009, 24(3):392-397.
[12] Davis LS, Bhutani S, Barnett SR, et al. Early gene expression changes with rush immunotherapy[J]. Clin Mol Allergy, 2011, 9:12.
[13] Durham SR, Nelson H. Allergen immunotherapy: A centenary celebration[J]. World Allergy Organ J, 2011, 4(6):104-106.
[14] 卢川,邱前辉,韩虹. 冲击免疫治疗变应性鼻炎[J]. 国际耳鼻咽喉头颈外科杂志, 2012, 36(4):235-237.
[15] 中国过敏性鼻炎研究协作组. 过敏性鼻炎皮下免疫治疗安全性[J]. 中国耳鼻咽喉头颈外科, 2017,24(1):1-14.
[16] Kim ME, Kim JE, Sung JM, et al. Safety of Accelerated schedules of subcutaneous allergen immunotherapy with house dust mite extract in patients with atopic dermatitis[J]. J Korean Med Sci, 2011, 26(9): 1159-1164.
[17] 周斌,陈向阳,鲁子健,等. 快速免疫治疗常年性变应性鼻炎[J].耳鼻咽喉头颈外科,2000, 7(6):333-335. ZHOU Bin, CHEN Xiangyang, LU Zijian, et al. Treatment of perennial allergic rhinitis with rushimmunotherapy[J]. Chin Arch Otolaryngol Head Neck Surg, 2000, 7(6):333-335.
[18] 方润琪,姜明华,谢淑琼,等.过敏性鼻炎及支气管哮喘快速脱敏疗法[J]. 云南医药, 1996, 17(3):199-200.
[19] 张玉华,孙进.快速减敏治疗变应性鼻炎疗效观察[J]. 实用临床医药杂志, 2009, 13(12):151-152.
[20] 邱前辉, 卢川, 陈建军, 等. 变应性鼻炎冲击免疫治疗的安全性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2014, 24(11):776-779.
[21] 谢薇, 张汉钟, 陈剑, 等. 冲击免疫治疗变应性鼻炎的有效性与安全性研究[J]. 中华耳鼻咽喉头颈外科杂志, 2015, 50(8):641-645. XIE Wei, ZHANG Hanzhong, CHEN Jian, et al. Clinical efficacy and safety of rush immunotherapy in patients with allergic rhinitis[J]. Chin J Otorhinolaryngol Head Neck Surg, 2015, 50(8):641-645.
[22] Bernstein DI, Wanner M, Borish L, et al. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001[J]. J Allergy Clin Immunol, 2004, 113(6):1129-1136.
[23] Toogood JH. CSM Update: Desensitisingvaccines[J]. Br Med J(Clin Res Ed), 1986, 293(6552):948.
[24] Lockey RF, Benedict LM, Turkeltaub PC, et al. Fatalities from immunotherapy(IT)and skin testing(ST)[J]. J Allergy Clin Immunol, 1987, 79(4):660-667.
[25] Reid MJ, Lockey RF, Turkeltaub PC. et al. Survey of fatalities from skin testing and immunotherapy 1985-1989[J]. J Allergy Clin Immunol, 1993, 92(1 pt 1):6-15.
[26] Rezvani M, Bernsterin DI. Anaphylactic reactions during immunotherapy[J]. Immunol Allergy Clin North Am, 2007, 27(2):295-307.
[27] Tanaka Y, Okafuji I, Narabayashi S, et al. Safety and efficacy of one-year rush subcutaneous immunotherapy in Japanese children, using house dust extract[J]. Arerugi, 2015, 64(8):1160-1168.
[28] Nam YH, Lee SK. Physicians recommendation and explanation is important in the initiation and maintenance of allergen immunotherapy[J]. Patient Prefer Adherence, 2017, 11: 381-387.
[29] Brehler R, Klimek L, Pfaar O, et al. Safety of a rush immunotherapy build-up schedule with depigmented polymerized allergen extracts[J]. Allergy Asthma Proc, 2010, 31(3):e31-38.
[30] Cox L. Advantages and disadvantages of accelerated immunotherapy schedules[J]. J Allergy Clin Immunol, 2008, 122(2): 432-434.
[31] Bachert C, VanCauwenbeerge P. The WHO ARIA(allergic rhinitis and its impact on asthma)initiative[J]. Chem Immunol Allergy, 2003, 82(3):119-126.
[32] Nagao M, Hiraguchi Y, Hosoki K, et al. Allergen- induced Basophil CD203c expression as a biomarker for rush immunotherapy in patients with Japanese cedar pollinosis[J]. Int Arch Allergy Immunol, 2008, 146(suppl 1):47-53.
[33] Smits W, Inglefield JT, Letz K, et al. Improved immunotherapy with a rapid allergen vaccination schedule: a study of 137 patients[J]. Ear Nose Throat J, 2003, 82(11):881-887.
[34] Durham SR, Walker SM, Varga EM, et al. Long-term clinical efficacy of grass-pollen immunotherapy[J]. N Engl J Med, 1999, 341(7):468-475.
[35] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 变应性鼻炎诊断和治疗指南[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(1):6-24. Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. Chinese guidelines for diagnosis and treatment of allergic rhinitis[J]. Chin J Otorhinolaryngol Head Neck Surg, 2016, 51(1):6-24.
[36] Kowalski ML, Ansotegui I, Aberer W, et al. Risk and safety requirements for diagnostic and therapeutic procedures in allergology:World Allergy Organization Statement[J]. World Allergy Organ J, 2016, 9(1):33.
[1] LYU Qian, TANG Yuan, GU Zijun, SHI Sailei, LIU Ping, WAN Wenjin. Current status of benefit finding among patients with allergic rhinitis and its influence factors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 21-28.
[2] GU Min, LU Meiping. Advances in the application of nanomedicine delivery systems in allergen immunotherapy for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 106-111.
[3] QIN Nana, LI Yufen, SUN Yuhao, WEI Jian, LI Qin. Effect of interleukin-13 receptor-α2 on nasal mucosal remodeling in rats with allergic rhinitis by TGF-β1/Smad signaling pathway [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 71-77.
[4] DU Kangli, ZHENG Zhenyu, XU Zhanjiang, ZHANG Yu, CHEN Lu, LU Mengyao. Construction and validation of risk prediction model for nasal septal deviation complicated with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 78-86.
[5] XIONG Qin, ZHANG Yan, WU Rina, LI Feng, TANG Lixing. Application of intranasal corticosteroids in pediatrics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 160-167.
[6] XU Xuemeng, FAN Lei, YU Wangbo, JIANG Zhiyue, PAN Chen, HUANG Yongqin. Meta-analysis of the efficacy of omalizumab in combination with specific immunotherapy for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 26-33.
[7] HUANG Huan, HUA Hongli, DENG Yuqin, JIANG Chengyang, WANG Yuwei, YANG Xinghai. Correlation of allergic rhinitis, tonsil adenoid hypertrophy, and sinusitis in children and analysis of its clinical guiding value [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 34-41.
[8] LIU Yijun, GU Yue, GUAN Dayu, YANG Yucheng, SHEN Yang. The long-term clinical efficacy and safety of vidian neurectomy in refractory allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 42-48.
[9] ZHANG Ting, WANG Meilan, GAO Yingqin. Research progress of IL-35 in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 139-147.
[10] ZHANG Zhuping, PENG Zican, XIAO Zhenlong, LI Cheng, YU Di, WANG Xinglong, CHEN Wei, Guo Bei. The value of a novel nasal secretion eosinophil cationic protein-myeloperoxidase test paper assay in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 129-134.
[11] LIU Chang, YANG Jingpu, GAO Yu, WANG Wenjia. Analysis of allergen detection results in children with allergic rhinitis in the Changchun area [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 51-58.
[12] ZHOU Heqing, SHEN Qi. Research progress on biomarkers of traditional Chinese medicine in the treatment of allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 168-176.
[13] WANG Manxian, ZHENG Quan, YANG Liang. Research progress in the treatment of allergic rhinitis with bacterial lysates [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 141-145.
[14] LIU Chang, FANG Hongyan, LIU Xiao, FU Dongna, WANG He, WANG Jing, YANG Jingpu. Analysis of sensitization characteristics of Artemisia pollen in autumn allergic rhinitis in the Changchun area of China [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 13-19.
[15] ZHANG Jie, CHEN Min, SHEN Zhengzheng, WU Yuhua, LIU Yuanhu, SUN Hao, TAN Xinhua, NI Shuren, YANG Shuxun, SHI Xuezheng, NI Xin. Study on the correlation between allergic rhinitis and coronavirus disease-2019 infection and symptoms in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 36-42.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd