盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察

Abstract

Abstract: To observe the efficacy and safety of the levofloxacin ear drop in the treatment of otitis media. Method: A randomized, doubleblind, multicenter, ofloxacin ear drop controlled trial was performed. Results: The data of 120 patients were analyzed, and 60 patients were in the group of levofloxacin ear drop and the other 60 in the group of ofloxacin ear drop. Efficacy assessment based on symptom score reducing index showed that the efficacy rate of levofloxacin ear drop was 96.67% and that of the ofloxacin ear drop was 85.00%; the eradication rate of pathogens in the group of levofloxacin ear drop was 96.15% and in the group of ofloxacin ear drop was 95.83%. No significant difference was showed between two groups (both P＜0.05). Conclusions: Levofloxacin ear drop is effective and safe in treating otitis media. The efficacy of levofloxacin ear drop is similar to that of ofloxacin ear drop.

Key words: Levofloxacin, Otitis media, Ofloxacin, Treatment outcome

XUE Wei-guo,SUN Jie,JIN Zheng,SHI Wen-bin,XIN Lu,LIN Guo-Jing,LI Jia-yun . [J].JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(4): 300-303 .

References

Related Articles 15

[1]	ZHANG Guomin, WANG Maohua, GAO Song, WU Wenbin, YU Youjun. Analysis of the surgical efficacy of adhesive otitis media under continuous irrigating mode for endoscopic ear surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 16-19.
[2]	SONG Jin, YIN Hui, GAO Xian, LI Yongtuan. Adult otitis media complicated with meningitis caused by Fusobacterium necrophorum: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 96-100.
[3]	ZHOU Ying, WANG Gang, WANG Lei, ZHANG Xiaoli, HAN Haolun, LI Baowei, SUN Zhezhe, WU Wei. A case of otitis media associated with pharyngeal reflux with literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 131-135.
[4]	FAN Yongjiang, HUANG Wei, HE Chengshan, SHEN Haitao, XU Zheng, HAO Yanan. Cytokine expression among patients with acute secretory otitis media after SARS-CoV-2 infection [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 1-6.
[5]	ZHONG Jiake, WANG Baiyang, YI Haijin. Granulomatosis with polyangiitis with initial otological symptoms combined with a nasopharynx lesion: a case report with literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(1): 6-14.
[6]	SUN Yan, YAO Hao, GU Li'an. Clinical efficacy of intratympanic administration of budesonide combined with ambroxol hydrochloride in the treatment of secretory otitis media in adults [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 77-82.
[7]	GAO Xinzhong, LING Zongtong, SHEN Ling, LIU Pingfang, LIN Xin, XU Yangyang. Analysis of the efficacy of balloon eustachian tuboplasty combined with adenoidectomy in the treatment of otitis media with effusion in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 7-12.
[8]	JIAO Xuemei, YANG Yang, LI Chunfeng, ZHANG Xiaolin. Effect of tympanic membrane insertion on the function of eustachian tube in children with secretory otitis media [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 60-63.
[9]	WU Hua, SUN Yongming, ZHENG Jianhua, CAI Xuehua. Application of endoscopic adenoids cryoablation combined with low-temperature plasma tympanostomy in the treatment of 55 children with adenoid hypertrophy and secretory otitis media [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 71-75.
[10]	ZHANG Jingyi, WANG Wenyi, RONG Lingyan, ZHANG Jiakui, SONG Xicheng. Curative effects of external application of traditional Chinese medicine in a hot salt bag combined with an intravenous drip of sodium aescinate in the treatment of nasal injury swelling [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 21-26.
[11]	. A preliminary study on the causes of poor development in three-dimensional magnetic resonance imaging via intratympanic gadolinium injection [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 61-66.
[12]	. The progress of otogenic bacterial labyrinthitis research [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 102-107.
[13]	. Relationship between adenoid size and torus tubarius type and secretory otitis media in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 121-126.
[14]	XU Ling, SUN Yan. Advances in research on the trifoliate factor family in the middle ear respiratory mucosal epithelium [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 93-98.
[15]	Chengcheng LIANG,Xin WANG,Dapeng LEI. Electronic nasopharyngoscopy for the diagnosis and treatment of otorhinolaryngologic diseases: A retrospective study of 27400 cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 107-110.