Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (6): 10-15.doi: 10.6040/j.issn.1673-3770.1.2019.061

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Rhinosinusitis and asthma in children: united airway disease

YANG Yifan1, CHENG Lei1,2   

  1. International Centre for Allergy Research, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Online:2019-11-20 Published:2019-12-23

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Abstract: Rhinosinusitis and asthma are common heterogeneous diseases in children and have a number of complex risk factors. It has been reported that chronic rhinosinusitis may contribute to asthma and that there is a close interaction between them. The concept of ‘united airway disease’ has been well accepted, and is supported by the coexistence of upper and lower airway inflammation as well as similar potential mechanisms involved in the pathogenesis. For patients with asthma, particularly those with severe asthma, the presence of rhinosinusitis needs to be detected, as it can influence asthma severity and clinical management. Therefore, controlling rhinosinusitis may benefit asthma. Physicians should be aware of these conditions, and an improved understanding of the underlying pathophysiological mechanisms may be useful for diagnostic and therapeutic purposes. In this article, we discuss the clinical features, pathogenesis, medical intervention, and biological treatment of rhinosinusitis and asthma in children.

Key words: Child, Chronic rhinosinusitis, Asthma, United airway disease, Type 2 inflammation

CLC Number: 

  • R725.6
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