中性粒细胞和嗜酸性粒细胞在慢性鼻窦炎中的相互影响及临床治疗思考

doi:10.6040/j.issn.1673-3770.0.2021.513

Abstract

Abstract: Chronic rhinosinusitis(CRS)has traditionally been classified as T-helper(Th)2 type inflammation(type 2 inflammation)with recruitment of predominantly eosinophils or as a Th1/Th17 type inflammation with predominantly neutrophils. These two inflammatory processes have long been thought of as being mutually exclusive in CRS. However, recent studies have found that neutrophilic(NEU)and eosinophilic(EOS)infiltrates increased significantly and influenced each other in the nasal mucosa or nasal polyp tissue in severe CRS. In this review, we examined the recent investigations into this mixed NEU/EOS inflammation in CRS in terms of cellular interactions and the implications on possible clinical treatment strategies.

Key words: Chronic rhinosinusitis, Neutrophil, Eosinophil, Endotype, Treatment

CLC Number:

R765.4

GU Yu, WAN Xin,XIAO Zi'an. The interaction between neutrophils and eosinophils in chronic rhinosinusitis and the implications on treatment options[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 56-63.

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