Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (2): 122-127.doi: 10.6040/j.issn.1673-3770.0.2021.518

• 综述 • Previous Articles     Next Articles

Current research on the relationship between obstructive sleep apnea hypopnea syndrome and tinnitus

WANG Nan1, HUANG Jing1, PEN Tao1, FENG Bo2   

  1. 1. Department of Clinical Medicine, North Sichuan Medical College, Department of Otorhinolaryngology, Head and Neck Department of Otorhinolaryngology, Second Clinical College of North Sichuan Medical College, Department of Otorhinolaryngology, Nanchong Central Hospital, Nanchong 637000, Sichuan, China;
    2. Otorhinolaryngology Head and Neck Surgery Chinese People's Liberation Army General Hospital, PLA Otorhinolaryngology Research Institute, National Otorhinolaryngology Clinical Research Center, Key Laboratory of Deafness Ministry of Education, Beijing Key Laboratory for Deafness Prevention and Treatment;
    big data National Engineering Laboratory of Medical Technology, General Hospital of Chinese PLA, Beijing 100853, China
  • Published:2023-03-30

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Abstract: Obstructive sleep apnea hypopnea syndrome(OSAHS)is a common type of sleep disorder. Long-term Obstructive sleep apnea and hypopnea can cause different degrees of hypoxemia, followed by tissue ischemia and hypoxia. Cause central and surrounding auditory system damage, auditory conduction pathway abnormalities, central auditory cortex adaptive changes, and then lead to tinnitus perception. The increase of 5-hydroxytryptamine(5-HT)neurotransmitter in OSAHS patients activates the auditory nucleus controlled by 5-HT and affects the neural electrical activity of the auditory nucleus, resulting in secondary tinnitus. The autonomic sympathetic nervous system of OSAHS patients excites and stimulates cochlear nerve fibers to induce tinnitus. At the same time activate limbic system and plant nervous system, and then produce anxiety, depression and other adverse emotions aggravate tinnitus. OSAHS patients suffer from long-term sleep structure disorder, resulting in sleep deprivation and accumulation of toxic metabolites in the brain, leading to central compensation disorder of tinnitus and secondary tinnitus.

Key words: Obstructive sleep apnea hypopnea syndrome, Tinnitus, Correlation, Research situation

CLC Number: 

  • R762
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